Abstract:
:The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in bone mass. Given the ability of tetracyclines to inhibit the breakdown of connective tissue collagen in experimental diabetes (and in other diseases), we examined the potential of this drug to prevent the osteopenia associated with STZ diabetes. To evaluate drug efficacy, the cortical and trabecular bone histomorphometry were analyzed and compared between vehicle-treated control and diabetic rats and control and diabetic rats treated orally with 20 mg/day of minocycline, a semisynthetic tetracycline. In addition, blood and urine glucose, body weight change, tibia lengths, cortical bone densities, and bone ash content were compared. At the end of the 26 day experimental period, diabetic (D) and minocycline-treated diabetic (MTD) rats were polyuric with reduced body weights and significantly elevated blood and urinary glucose levels (p < 0.01). Compared to control (C) and minocycline-treated control (MTC) animals, the periosteal and cancellous bone formation in the D rats had virtually ceased (p < 0.001), and the cancellous bone mass in the tibial metaphysis was reduced 47% (p < 0.01). In contrast, bone formation rates in the MTD animals were increased compared to the D rats (p < 0.001), while cancellous bone areas in the MTD animals were essentially equivalent to those observed in the C and MTC groups. Moreover, growth plate thickness, reduced 43% in the D rats, was preserved in the diabetic animals treated with minocycline. These results demonstrate that minocycline treatment of the streptozotocin diabetic rat maintains normal bone formation, normalizes growth plate thickness, and prevents cancellous bone loss.
journal_name
Bonejournal_title
Boneauthors
Bain S,Ramamurthy NS,Impeduglia T,Scolman S,Golub LM,Rubin Cdoi
10.1016/s8756-3282(97)00104-xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
147-53issue
2eissn
8756-3282issn
1873-2763pii
S875632829700104Xjournal_volume
21pub_type
杂志文章相关文献
BONE文献大全abstract::Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/s8756-3282(02)00845-1
更新日期:2002-10-01 00:00:00
abstract::It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90011-7
更新日期:1991-01-01 00:00:00
abstract::The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00116-u
更新日期:1995-06-01 00:00:00
abstract::Radiation of the hip is an established method to prevent heterotopic ossification (HO) following total hip arthroplasty (THA) but the precise mechanism is unclear. As inflammatory processes are suggested to be involved in the pathogenesis of HO, we hypothesized that the preoperative irradiation impacts local immune co...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.03.020
更新日期:2013-07-01 00:00:00
abstract::It is now well established that important regulatory interactions occur between the cells in the hematopoietic, immune and skeletal systems (osteoimmunology). B lymphocytes (B cells) are responsible for the generation and production of antibodies or immunoglobulins in the body. Together with T cells these lymphocytes ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2010.06.011
更新日期:2010-09-01 00:00:00
abstract::A stabilized tibia fracture model was used in young (8-week old) and aged (1-year old) mice to define the relative bone regenerative potential and the relative responsiveness of the periosteal progenitor population with aging and PTH 1-34 (PTH) systemic therapy. Bone regeneration was assessed through gene expressions,...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.02.002
更新日期:2014-05-01 00:00:00
abstract::The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115496
更新日期:2020-09-01 00:00:00
abstract::The present work was designed to investigate the effects of oscillating fluid flow on gap junctional intercellular communication (GJIC) and the gap junction protein connexin (Cx) 43 in osteocyte-like MLOY-4 cells. Cells were exposed for 1 h to oscillating fluid flow at a shear stress of +/-10 dyn/cm(2) and a frequency...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00167-4
更新日期:2003-07-01 00:00:00
abstract::Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has been reported that older age is associated with higher serum levels of the inflammatory cytokine IL-18. In the present study, we investigated the long-term role of serum IL-18 in cartilage loss in vivo using a new strain o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.01.031
更新日期:2008-06-01 00:00:00
abstract::FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.09.021
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.06.001
更新日期:2007-10-01 00:00:00
abstract::Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan. However, its efficacy for hip fracture has not been established. To gain insight into the effect of weekly teriparatide on the hip, hip struct...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2014.04.004
更新日期:2014-07-01 00:00:00
abstract::The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90455-6
更新日期:1992-01-01 00:00:00
abstract::Clinically, osteopenia or low bone mass has been observed in a variety of chronic inflammatory diseases, and elevated proinflammatory mediators have implicated this process. The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation. Time-release pellets designed to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.008
更新日期:2006-03-01 00:00:00
abstract::The objects of this study were to determine the responses of a cancellous bone site with a closed growth plate (the distal tibial metaphysis, DTM) to ovariectomy (OVX) and OVX plus a prostaglandin E2 (PGE2) treatment, and compare the site's response to previous findings reported for another site (the proximal tibial m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90700-5
更新日期:1994-03-01 00:00:00
abstract::Bone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish co...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.02.004
更新日期:2004-06-01 00:00:00
abstract::Diabetes is associated with a number of lower extremity orthopedic conditions and complications including fractures, Charcot neuroarthropathy, plantar ulcers, and infection. These complications are of significant clinical concern in terms of morbidity, mortality, and socioeconomic costs. A review of each condition is ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.07.029
更新日期:2016-01-01 00:00:00
abstract::The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00148-8
更新日期:1997-10-01 00:00:00
abstract::Endochondral bone growth is abnormal in 6 of the 11 types of mucopolysaccharidoses (MPS) disorders; resulting in short stature, reduced size of the thoracic cavity and compromised manual dexterity. Current therapies for MPS have had a limited effect on bone growth and to improve these therapies or develop adjunct appr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115195
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115524
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate non-compliance with osteoporosis medications as well as its implications for health and economic outcomes in actual practice. STUDY DESIGN:Data on demographics, prescription drug dispensing, physician services and hospitalizations were obtained from a US managed care database for women with osteo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.10.022
更新日期:2006-06-01 00:00:00
abstract::Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.04.026
更新日期:2013-08-01 00:00:00
abstract::Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90004-g
更新日期:1992-01-01 00:00:00
abstract::Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.07.012
更新日期:2012-01-01 00:00:00
abstract::To assess the affect of mild diabetes on calcium metabolism in an animal model, we evaluated calcium homeostasis before pregnancy and during gestation and lactation in non-insulindependent (NIDD) diabetic rat mothers and their neonates (NeoDM). Plasma glucose, calcium (Ca), magnesium (Mg), phosphate (Pi), and immunore...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90124-4
更新日期:1987-01-01 00:00:00
abstract::Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00164-2
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.016
更新日期:2019-10-01 00:00:00
abstract::Bone turnover occurs at discreet sites in the remodeling skeleton. The focal nature of this process indicates that local cues may facilitate the activation of bone cells by systemic factors. Nucleotides such as adenosine triphosphate (ATP) are locally released, short-lived, yet potent extracellular signaling molecules...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(01)00430-6
更新日期:2001-05-01 00:00:00
abstract::We investigated the role of 3,5,3'-tri-iodothyronine (T3) in regulating differentiation of osteoprogenitor cells and also studied the effects of the glucocorticoid hormone dexamethasone (Dex) on the T3-induced effects on osteoprogenitor populations. This was done by determining the effects of either hormone alone, or ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00102-j
更新日期:1995-05-01 00:00:00
abstract::Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bon...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.02.006
更新日期:2005-05-01 00:00:00