Abstract：
:The effects of pregnancy and lactation on bone histomorphometry have been studied extensively in rats and dogs. However, these models differ greatly in reproductive physiology compared with women. The purpose of this study was to evaluate histomorphometric changes in iliac crest bone biopsies taken from cynomolgus monkeys (Macaca fascicularis), animals similar to women both skeletally and reproductively. After fluorochrome labeling, paired iliac crest bone biopsies were collected and subjected to structural and dynamic histomorphometric analyses during the third trimester and 3 months postpartum in one group (n=16), at 3 and 9 months postpartum in the second group (n=14), and at 4 month intervals in a nonpregnant control group (n=6). Serum was collected at the time of surgery to measure total alkaline phosphatase (ALP), bone gla-protein (BGP), calcium, and estradiol. Trabecular thickness increased significantly between 3 and 9 months postpartum. Bone formation rates did not differ between control and pregnant monkeys, but were significantly increased during lactation (3 months postpartum) and remained elevated at 9 months postpartum. ALP and BGP levels were elevated at 3 months postpartum, compared with levels during pregnancy, and remained elevated at 9 months postpartum. Estradiol concentrations were greatly elevated during pregnancy, dropped below normal nonpregnant levels by 3 months postpartum, and remained suppressed at 9 months postpartum. These results suggest that, during the third trimester, the rate of bone turnover was not altered, but lactational demands for calcium were met in part by increased bone turnover.
journal_name
Bonejournal_title
Boneauthors
Lees CJ,Jerome CPdoi
10.1016/s8756-3282(98)00032-5subject
Has Abstractpub_date
1998-05-01 00:00:00pages
545-9issue
5eissn
8756-3282issn
1873-2763pii
S8756-3282(98)00032-5journal_volume
22pub_type
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