The role of endogenous GIP and GLP-1 in postprandial bone homeostasis.

abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...

journal_title：Bone

authors： Yamaza T,Tsuji Y,Goto T,Kido MA,Nishijima K,Moroi R,Akamine A,Tanaka T

更新日期：2001-07-01 00:00:00

abstract：:In an effort to elucidate the interplay between mechanical load and proteolytic gene expression in arthritic tissue degradation, we investigated cellular morphology and mRNA levels of matrix metalloproteinase-13 (MMP-13) genes under mechanical stress in human MH7A synovial cells. The cells were isolated from the knee ...

journal_title：Bone

authors： Sun HB,Yokota H

更新日期：2001-04-01 00:00:00

abstract：:Iliac crest bone biopsies from 62 patients (42 women, 20 men; median age 59 years; range 17-79 years) with primary hyperparathyroidism (PHP) were examined. Static and structural parameters were compared with 30 age- and sex-matched normal controls. Eighteen sex-matched younger controls were used for evaluation of the ...

journal_title：Bone

authors： Christiansen P,Steiniche T,Brockstedt H,Mosekilde L,Hessov I,Melsen F

更新日期：1993-09-01 00:00:00

abstract：:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...

journal_title：Bone

authors： Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JY

更新日期：2003-05-01 00:00:00

abstract：:Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...

journal_title：Bone

authors： Quinn JM,Whitty GA,Byrne RJ,Gillespie MT,Hamilton JA

更新日期：2002-01-01 00:00:00

abstract：:Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect wa...

journal_title：Bone

authors： Cointry GR,Mondelo N,Zanchetta JR,Montuori E,Ferretti JL

更新日期：1995-10-01 00:00:00

abstract：:Proteins are an essential part of essentially all biological processes, and there is enormous variation in protein forms and concentrations that is not reflected in DNA or RNA. Recently there have been rapid advances in the ability to measure protein sequence, modification and concentration, particularly with methods ...

journal_title：Bone

authors： Nielson CM,Jacobs JM,Orwoll ES

更新日期：2019-09-01 00:00:00

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Bone scintigraphy used as a diagnostic technique frequently yields non-specific intense uptake by vertebrae. Bone biopsy may therefore be required to establish a diagnosis in cases of Paget's disease of bone. The aim of the study was to ascertain the sensitivity and specificity of two new images-heart sign a...

journal_title：Bone

authors： Rotés-Sala D,Monfort J,Solano A,Miralles E,Vila J,Carbonell J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Vertebral fractures (VF) upon Denosumab (DMAB) discontinuation were first described as a distinct phenomenon in 2015, yet the magnitude of this event remains undetermined. OBJECTIVES:To estimate fracture risk after DMAB discontinuation, in a real-world setting. METHODS:The computerized database of a 2.3-mi...

journal_title：Bone

authors： Tripto-Shkolnik L,Fund N,Rouach V,Chodick G,Shalev V,Goldshtein I

更新日期：2020-01-01 00:00:00

abstract：:Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...

journal_title：Bone

authors： Bellows CG,Ciaccia A,Heersche JN

更新日期：1998-08-01 00:00:00

abstract：:To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...

journal_title：Bone

authors： Bjarnason NH,Bjarnason K,Hassager C,Christiansen C

更新日期：1997-02-01 00:00:00

abstract：:Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...

journal_title：Bone

authors： Tatara MR,Sliwa E,Krupski W,Brodzki A,Pasternak K

更新日期：2006-07-01 00:00:00

abstract：:Osteoporosis and fracture risk are common complex diseases, caused by an interaction of numerous disease susceptibility genes and environmental factors. With the advances in genomic technologies, large-scale genome-wide association studies (GWAS) have been performed which have broadened our understanding of the geneti...

journal_title：Bone

authors： Trajanoska K,Rivadeneira F

更新日期：2019-09-01 00:00:00

abstract：:The present work was designed to investigate the effects of oscillating fluid flow on gap junctional intercellular communication (GJIC) and the gap junction protein connexin (Cx) 43 in osteocyte-like MLOY-4 cells. Cells were exposed for 1 h to oscillating fluid flow at a shear stress of +/-10 dyn/cm(2) and a frequency...

journal_title：Bone

authors： Alford AI,Jacobs CR,Donahue HJ

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ossification processes. Alterations in transforming growth factor β (TGFβ) s...

journal_title：Bone

authors： de Kroon LMG,van den Akker GGH,Brachvogel B,Narcisi R,Belluoccio D,Jenner F,Bateman JF,Little CB,Brama PAJ,Blaney Davidson EN,van der Kraan PM,van Osch GJVM

更新日期：2018-11-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...

journal_title：Bone

authors： Roschger P,Gupta HS,Berzlanovich A,Ittner G,Dempster DW,Fratzl P,Cosman F,Parisien M,Lindsay R,Nieves JW,Klaushofer K

更新日期：2003-03-01 00:00:00

abstract：:Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...

journal_title：Bone

authors： Adam C,Glück L,Ebert R,Goebeler M,Jakob F,Schmidt M

更新日期：2018-06-01 00:00:00

abstract：:Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical propertie...

journal_title：Bone

authors： Wear KA,Nagaraja S,Dreher ML,Sadoughi S,Zhu S,Keaveny TM

更新日期：2017-10-01 00:00:00

abstract：:Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...

journal_title：Bone

authors： Saito M,Grynpas MD,Burr DB,Allen MR,Smith SY,Doyle N,Amizuka N,Hasegawa T,Kida Y,Marumo K,Saito H

更新日期：2015-04-01 00:00:00

abstract：:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...

journal_title：Bone

authors： Sugimoto M,Futaki N,Harada M,Kaku S

更新日期：2013-01-01 00:00:00

abstract：:Bone morbidity associated with antineoplastic treatment is a significant health concern for postmenopausal breast cancer patients. Trials have demonstrated that adjuvant therapy with an Aromatase Inhibitor is associated with an increase in musculoskeletal disorders and bone fractures. The objective of this study was t...

journal_title：Bone

authors： Szabo KA,Webber CE,Adachi JD,Tozer R,Gordon C,Papaioannou A

更新日期：2011-02-01 00:00:00

abstract：:It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...

journal_title：Bone

authors： Manolagas SC

更新日期：1995-08-01 00:00:00

abstract：:The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoc...

journal_title：Bone

authors： Thacher TD,Pettifor JM,Tebben PJ,Creo AL,Skrinar A,Mao M,Chen CY,Chang T,San Martin J,Carpenter TO

更新日期：2019-05-01 00:00:00

abstract：:CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Prev...

journal_title：Bone

authors： Kos O,Hughson RL,Hart DA,Clément G,Frings-Meuthen P,Linnarsson D,Paloski WH,Rittweger J,Wuyts F,Zange J,Gorczynski RM

更新日期：2014-03-01 00:00:00

abstract：:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effect...

journal_title：Bone

authors： Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A

更新日期：2017-12-01 00:00:00

abstract：:During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...

journal_title：Bone

authors： Wallach S,Rousseau G,Martin L,Azria M

更新日期：1999-11-01 00:00:00

abstract：:This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...

journal_title：Bone

authors： Harris SS,Wood MJ,Dawson-Hughes B

更新日期：1995-04-01 00:00:00

abstract：:Osteoclasts (OCs) attach to the extracellular matrix via specialized attachment structures called podosomes, which form a prominent F-actin-rich ring that is thought to correspond to the sealing zone of resorbing OCs. Calcitonin (CT), a 32-amino acid polypeptide, inhibits bone resorption by decreasing motility, induci...

journal_title：Bone

authors： Shyu JF,Shih C,Tseng CY,Lin CH,Sun DT,Liu HT,Tsung HC,Chen TH,Lu RB

更新日期：2007-05-01 00:00:00