The response in spinal bone mass to tibolone treatment is related to bone turnover in elderly women.

abstract：:The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

journal_title：Bone

authors： Spain L,Yang L,Wilkinson JM,McCloskey E

更新日期：2021-03-01 00:00:00

abstract：:Matrix Extracellular Phospho-glycoprotEin (MEPE) and proteases are elevated and PHEX is defective in HYP. PHEX prevents proteolysis of MEPE and release of a protease-resistant MEPE-ASARM peptide, an inhibitor of mineralization (minhibin). Thus, in HYP, mutated PHEX may contribute to increased ASARM peptide release. Mo...

journal_title：Bone

authors： Rowe PS,Garrett IR,Schwarz PM,Carnes DL,Lafer EM,Mundy GR,Gutierrez GE

更新日期：2005-01-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...

journal_title：Bone

authors： Pavey GJ,Qureshi AT,Tomasino AM,Honnold CL,Bishop DK,Agarwal S,Loder S,Levi B,Pacifici M,Iwamoto M,Potter BK,Davis TA,Forsberg JA

更新日期：2016-09-01 00:00:00

abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

journal_title：Bone

authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Autosomal recessive osteopetrosis (ARO) is a rare congenital disorder of defective bone resorption. The inability of osteoclasts to resorb bone compromises the development of bone marrow cavity, and ultimately, leads to defective hematopoiesis and death within the first decade. The only curative treatment cur...

journal_title：Bone

authors： Maximova N,Zennaro F,Gregori M,Boz G,Zanon D,Mbalaviele G

更新日期：2020-01-01 00:00:00

abstract：:Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...

journal_title：Bone

authors： Wang Y,Liu W,Masuyama R,Fukuyama R,Ito M,Zhang Q,Komori H,Murakami T,Moriishi T,Miyazaki T,Kitazawa R,Yoshida CA,Kawai Y,Izumi S,Komori T

更新日期：2012-01-01 00:00:00

abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...

journal_title：Bone

authors： Adami S,Rossini M

更新日期：1992-01-01 00:00:00

abstract：:Achondroplasia (ACH), the most common form of human dwarfism is caused by a mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene, resulting in constitutive activation of the receptor. Typical radiological features include shortening of the tubular bones and macrocephaly, due to disruption of endochondral o...

journal_title：Bone

authors： Pannier S,Mugniery E,Jonquoy A,Benoist-Lasselin C,Odent T,Jais JP,Munnich A,Legeai-Mallet L

更新日期：2010-11-01 00:00:00

abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

journal_title：Bone

authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

更新日期：2007-04-01 00:00:00

abstract：:Over 60% of our severely combat-injured patient population develops radiographically apparent heterotopic ossification. Nearly a third of these require surgical excision of symptomatic lesions, a procedure that is fraught with complications, and delays or regresses functional rehabilitation in many cases. Unfortunatel...

journal_title：Bone

authors： Crane NJ,Polfer E,Elster EA,Potter BK,Forsberg JA

更新日期：2013-12-01 00:00:00

abstract：:The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...

journal_title：Bone

authors： Oussoren E,Wagenmakers MAEM,Link B,van der Meijden JC,Pijnappel WWMP,Ruijter GJG,Langeveld M,van der Ploeg AT

更新日期：2021-02-01 00:00:00

abstract：:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of ...

journal_title：Bone

authors： Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins AS

更新日期：2014-03-01 00:00:00

abstract：:We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using this coculture system, we examined the effects of c-fos antisens...

journal_title：Bone

authors： Udagawa N,Chan J,Wada S,Findlay DM,Hamilton JA,Martin TJ

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chronic kidney disease (CKD) is commonly associated with mineral and bone metabolism disorders, but these are less frequently studied in non-dialysis CKD patients than in dialysis patients. We examined and described international variation in mineral and bone disease (MBD) markers and their tr...

journal_title：Bone

authors： Liabeuf S,McCullough K,Young EW,Pisoni R,Zee J,Reichel H,Pecoits-Filho R,Port FK,Stengel B,Csomor PA,Metzger M,Robinson B,Massy ZA

更新日期：2019-12-01 00:00:00

abstract：:The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...

journal_title：Bone

authors： Catherwood BD,Marcus R,Madvig P,Cheung AK

更新日期：1985-01-01 00:00:00

abstract：:Measurement of bone mineral density (BMD) is the clinical gold standard in cases of compromised skeletal integrity, such as with osteoporosis. While BMD is a useful measurement to index skeletal health, it is also limited since it cannot directly assess any mechanical properties. The ability to directly assess mechani...

journal_title：Bone

authors： Beutel BG,Kennedy OD

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) s...

journal_title：Bone

authors： Fassio A,Adami G,Benini C,Vantaggiato E,Saag KG,Giollo A,Lippolis I,Viapiana O,Idolazzi L,Orsolini G,Rossini M,Gatti D

更新日期：2019-06-01 00:00:00

abstract：:Proteins are an essential part of essentially all biological processes, and there is enormous variation in protein forms and concentrations that is not reflected in DNA or RNA. Recently there have been rapid advances in the ability to measure protein sequence, modification and concentration, particularly with methods ...

journal_title：Bone

authors： Nielson CM,Jacobs JM,Orwoll ES

更新日期：2019-09-01 00:00:00

abstract：:Bone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish co...

journal_title：Bone

authors： Vaughan T,Reid DM,Morrison NA,Ralston SH

更新日期：2004-06-01 00:00:00

abstract：:Sclerostin, product of the SOST gene, is an important determinant of bone formation and resorption. Adolescents with anorexia nervosa (AN) have low bone density and decreased levels of bone turnover markers. However, sclerostin has not been examined in AN as a potential mediator of impaired bone metabolism. Our study ...

journal_title：Bone

authors： Faje AT,Fazeli PK,Katzman DK,Miller KK,Breggia A,Rosen CJ,Mendes N,Klibanski A,Misra M

更新日期：2012-09-01 00:00:00

abstract：:The role of vitamin D receptor (VDR) gene polymorphisms in the determination of bone mass and bone turnover is controversial in women. The aim of the study was to determine whether VDR polymorphisms are associated with indices of bone mineral density (BMD) (by dual-energy X-ray absorptiometry and by ultrasound) and/or...

journal_title：Bone

authors： Van Pottelbergh I,Goemaere S,De Bacquer D,De Paepe A,Kaufman M

更新日期：2002-11-01 00:00:00

abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

journal_title：Bone

authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

更新日期：2012-09-01 00:00:00

abstract：:The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...

journal_title：Bone

authors： Valenta A,Roschger P,Fratzl-Zelman N,Kostenuik PJ,Dunstan CR,Fratzl P,Klaushofer K

更新日期：2005-07-01 00:00:00

abstract：:The osteoprotegerin (OPG)/receptor activator of NF-kappaB ligand (RANKL) axis is thought to be involved in the upregulation of bone turnover following sex steroid deficiency. Here, we investigated the effects of orchiectomy (ORX) on bone turnover and free soluble RANKL (sRANKL) in aged rats. Free, bioactive sRANKL is ...

journal_title：Bone

authors： Proell V,Xu H,Schüler C,Weber K,Hofbauer LC,Erben RG

更新日期：2009-10-01 00:00:00

abstract：:Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40...

journal_title：Bone

authors： Kung AW,Yeung SS,Lau KS

更新日期：1998-04-01 00:00:00

abstract：:Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...

journal_title：Bone

authors： van Beek E,Oostendorp-van de Ruit M,van der Wee-Pals L,Bloys H,van de Bent C,Papapoulos S,Löwik C

更新日期：1995-07-01 00:00:00

abstract：UNLABELLED:We identified regions inside the proximal femur that are most strongly associated with hip fracture. Bone densitometry based on such fracture-critical regions showed improved power in discriminating fracture patients from controls. INTRODUCTION:Hip fractures typically occur in lateral falls, with focal mech...

journal_title：Bone

authors： Li W,Kornak J,Harris T,Keyak J,Li C,Lu Y,Cheng X,Lang T

更新日期：2009-04-01 00:00:00

abstract：:The objects of this study were to determine the responses of a cancellous bone site with a closed growth plate (the distal tibial metaphysis, DTM) to ovariectomy (OVX) and OVX plus a prostaglandin E2 (PGE2) treatment, and compare the site's response to previous findings reported for another site (the proximal tibial m...

journal_title：Bone

authors： Ma YF,Ke HZ,Jee WS

更新日期：1994-03-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...

journal_title：Bone

authors： Kosugi K,Tajima T,Menuki K,Okuma KF,Tokuda K,Fukuda H,Okada Y,Tsukamoto M,Yamanaka Y,Zenke Y,Sakai A

更新日期：2020-07-01 00:00:00