Prostaglandin E2 adds bone to a cancellous bone site with a closed growth plate and low bone turnover in ovariectomized rats.

abstract：:The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By...

journal_title：Bone

authors： Macias BR,Aspenberg P,Agholme F

更新日期：2013-04-01 00:00:00

abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...

journal_title：Bone

authors： Mueller TL,Christen D,Sandercott S,Boyd SK,van Rietbergen B,Eckstein F,Lochmüller EM,Müller R,van Lenthe GH

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Cancer progression and metastasis occur such that cells with acquired mutations enhancing growth and survival (or inhibiting cell death) increase in number, a concept that has been recognized as analogous to Darwinian evolution of species since Peter C. Nowell's description in 1976. Selective forces include ...

journal_title：Bone

authors： Arnold RS,Fedewa SA,Goodman M,Osunkoya AO,Kissick HT,Morrissey C,True LD,Petros JA

更新日期：2015-09-01 00:00:00

abstract：:Two major mechanisms that could potentially be responsible for toughening in mineralized tissues, such as bone and dentin, have been identified-microcracking and crack bridging. While evidence has been reported for both mechanisms, there has been no consensus thus far on which mechanism plays the dominant role in toug...

journal_title：Bone

authors： Nalla RK,Kruzic JJ,Ritchie RO

更新日期：2004-05-01 00:00:00

abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

journal_title：Bone

authors： Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of...

journal_title：Bone

authors： van Dijk CE,de Boer MR,Koppes LL,Roos JC,Lips P,Twisk JW

更新日期：2009-03-01 00:00:00

abstract：:In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...

journal_title：Bone

authors： Palvanen M,Kannus P,Niemi S,Parkkari J

更新日期：2010-05-01 00:00:00

abstract：:Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...

journal_title：Bone

authors： Di Fiore R,Marcatti M,Drago-Ferrante R,D'Anneo A,Giuliano M,Carlisi D,De Blasio A,Querques F,Pastore L,Tesoriere G,Vento R

更新日期：2014-03-01 00:00:00

abstract：:Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...

journal_title：Bone

authors： Heaney RP

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...

journal_title：Bone

authors： Lavocat F,Osta B,Miossec P

更新日期：2016-06-01 00:00:00

abstract：:The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...

journal_title：Bone

authors： Pereira LJ,Macari S,Coimbra CC,Pereira TDSF,Barrioni BR,Gomez RS,Silva TA,Paiva SM

更新日期：2020-09-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:Chronic alcohol abuse is a risk factor for osteoporosis in men. Human recombinant parathyroid hormone (1-34) (PTH) therapy increases bone mass in patients with osteoporosis. The purpose of the present study was to determine whether PTH is effective in increasing bone formation and bone mass in a rat model for establis...

journal_title：Bone

authors： Sibonga JD,Iwaniec UT,Shogren KL,Rosen CJ,Turner RT

更新日期：2007-04-01 00:00:00

abstract：:Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1(-...

journal_title：Bone

authors： Hajjawi MO,MacRae VE,Huesa C,Boyde A,Millán JL,Arnett TR,Orriss IR

更新日期：2014-12-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...

journal_title：Bone

authors： Jonasson G,Sundh V,Ahlqwist M,Hakeberg M,Björkelund C,Lissner L

更新日期：2011-10-01 00:00:00

abstract：:Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...

journal_title：Bone

authors： Pavey GJ,Qureshi AT,Tomasino AM,Honnold CL,Bishop DK,Agarwal S,Loder S,Levi B,Pacifici M,Iwamoto M,Potter BK,Davis TA,Forsberg JA

更新日期：2016-09-01 00:00:00

abstract：:Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...

journal_title：Bone

authors： Shi C,Qi J,Huang P,Jiang M,Zhou Q,Zhou H,Kang H,Qian N,Yang Q,Guo L,Deng L

更新日期：2014-11-01 00:00:00

abstract：:While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...

journal_title：Bone

authors： Omata Y,Frech M,Lucas S,Primbs T,Knipfer L,Wirtz S,Kadono Y,Saito T,Tanaka S,Sarter K,Schett G,Zaiss MM

更新日期：2020-07-01 00:00:00

abstract：:The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear. The aim of this study was to assess the effect of low dose vitamin D supplementation during pregnancy on bony anthropometric aspects of the fetus. In this prospective randomized trial, 140 patients were divided into two equal...

journal_title：Bone

authors： Vafaei H,Asadi N,Kasraeian M,Shahraki HR,Bazrafshan K,Namazi N

更新日期：2019-05-01 00:00:00

abstract：:In patients with osteoporosis, alendronate treatment causes an increase in bone mineral density (BMD) and a decrease in fracture incidence. Alendronate acts by changing the bone remodeling process. Changes in bone remodeling resulting in decreased remodeling space, increased bone balance per remodeling cycle, and incr...

journal_title：Bone

authors： Hernandez CJ,Beaupré GS,Marcus R,Carter DR

更新日期：2001-12-01 00:00:00

abstract：:The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...

journal_title：Bone

authors： Siebler T,Robson H,Shalet SM,Williams GR

更新日期：2002-10-01 00:00:00

abstract：:We investigated the effect of 2-beta-(3-hydroxypropoxy)-1alpha,25-dihydroxyvitamin D3 (ED-71) on the modeling of bone in distraction osteogenesis. The tibiae of 30 rabbits were lengthened by 10 mm in 10 days. Following osteotomy, ED-71 (0.05 microg/kg) was administered subcutaneously twice a week to the ED-71 group un...

journal_title：Bone

authors： Yamane K,Okano T,Kishimoto H,Hagino H

更新日期：1999-03-01 00:00:00

abstract：:Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual a...

journal_title：Bone

authors： Pauchard Y,Liphardt AM,Macdonald HM,Hanley DA,Boyd SK

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:To assess the ability of the Spanish version of the WHO fracture risk assessment tool (FRAX®) to predict the observed incident fractures in the ECOSAP Study cohort. METHODS:5201 women, aged 65 or older, were enrolled in a three-year, prospective study by a non-randomized sampling of consecutive cases in 58 pri...

journal_title：Bone

authors： González-Macías J,Marin F,Vila J,Díez-Pérez A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...

journal_title：Bone

authors： Frost M,Tencerova M,Andreasen CM,Andersen TL,Ejersted C,Svaneby D,Qui W,Kassem M,Zarei A,McAlister WH,Veis DJ,Whyte MP,Frederiksen AL

更新日期：2019-04-01 00:00:00

abstract：:Matrix extracellular phosphoglycoprotein (MEPE) is an extracellular matrix protein that was first detected in tumor-induced osteomalacia (TIO). Investigations in mice revealed that MEPE is expressed in bone and teeth in a maturation-dependent manner, reaching its maximum during mineralization. However, from knockout e...

journal_title：Bone

authors： Siggelkow H,Schmidt E,Hennies B,Hüfner M

更新日期：2004-08-01 00:00:00

abstract：:In this study we report on histological and ultrastructural investigations of the mandibular cortical bone in a case of autosomal dominant osteopetrosis type II complicated by mandibular osteomyelitis. Histologically, there was a marked increase in the number and size of osteoclasts on the inner bone surface. An undec...

journal_title：Bone

authors： Semba I,Ishigami T,Sugihara K,Kitano M

更新日期：2000-09-01 00:00:00

abstract：:Bisphosphonates are widely used in the treatment of osteoporosis and contribute to the reduction of bone fractures. Ibandronate (IBN) is a highly potent, nitrogen-containing bisphosphonate, which is administered orally or intravenously at extended dosing intervals. Vitamin D or active vitamin D3 derivatives are also u...

journal_title：Bone

authors： Sakai S,Takeda S,Sugimoto M,Shimizu M,Shimonaka Y,Yogo K,Hashimoto J,Bauss F,Endo K

更新日期：2015-12-01 00:00:00