当前位置： SCI文献检索 > BONE期刊下所有文献 > Neuropeptide Y Y1 receptor antagonism increases bone mass in mice.

Neuropeptide Y Y1 receptor antagonism increases bone mass in mice.

Abstract：

:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic treatment option for improving bone mass. Here we show that oral administration of the selective Y1 receptor antagonist BIBO3304 for 8 weeks dose-dependently increases bone mass in mice. Histomorphometric analysis revealed a significant 1.5-fold increase in cancellous bone volume in the femora of mice treated with BIBO3304. Furthermore, bone microarchitecture was improved, with greater trabecular number and trabecular thickness. This increase in bone mass was associated with a significant increase in bone anabolic activity of osteoblasts and, interestingly, was evident despite a coincident increase in bone resorption, as evidenced by an increase in the number of the osteolytic osteoclasts. Changes were also evident in cortical bone, with a significant increase in periosteal mineral apposition rate. Importantly, no adverse extra-skeletal side effects were observed through Y1 receptor antagonism over the 8-week treatment period, with no effects of even the higher BIBO3304 dose on body weight, adiposity, energy metabolism or circulating corticosterone levels. Taken together, this work describes the first NPY-based anabolic treatment for improving bone mass, and highlights the therapeutic potential of blocking Y1 receptor signalling for the prevention of, or recovery from, degenerative skeletal diseases.

journal_name

Bone

journal_title

Bone

authors

Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

doi

10.1016/j.bone.2012.03.020

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

8-16

issue

1

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(12)00738-7

journal_volume

51

pub_type

杂志文章

相关文献

BONE文献大全
  • Evaluating the relationship between muscle and bone modeling response in older adults.

    abstract：:Bone modeling, the process that continually adjusts bone strength in response to prevalent muscle-loading forces throughout an individual's lifespan, may play an important role in bone fragility with age. Femoral stress, an index of bone modeling response, can be estimated using measurements of DXA derived bone geomet...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.06.012

    authors： Reider L,Beck T,Alley D,Miller R,Shardell M,Schumacher J,Magaziner J,Cawthon PM,Barbour KE,Cauley JA,Harris T,Health ABC Study.

    更新日期：2016-09-01 00:00:00

  • Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFalpha and GalR2 mRNA induced by chronic daily injections of an injurious vehicle.

    abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.10.018

    authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

    更新日期：2007-04-01 00:00:00

  • Bone morphogenetic protein-7 selectively enhances mechanically induced bone formation.

    abstract：:The responses of bone cells to skeletal loading are clearly an important factor in bone biology, but much remains to be learned about the role of these responses in skeletal development, maintenance, and tissue repair. Bone morphogenetic proteins (BMPs) are key regulators of bone formation. We examined the effect of B...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(02)00865-7

    authors： Cheline AJ,Reddi AH,Martin RB

    更新日期：2002-11-01 00:00:00

  • Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.

    abstract：:A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.11.003

    authors： Kwun IS,Cho YE,Lomeda RA,Shin HI,Choi JY,Kang YH,Beattie JH

    更新日期：2010-03-01 00:00:00

  • Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts.

    abstract：:The proliferation inhibitor of the macrolide class, everolimus, is a drug shown to be effective in the prevention of organ transplant rejection and to have a potential in the treatment of rheumatoid arthritis and certain cancers. As these diseases or their current treatments are associated with bone loss, we examined ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.07.013

    authors： Kneissel M,Luong-Nguyen NH,Baptist M,Cortesi R,Zumstein-Mecker S,Kossida S,O'Reilly T,Lane H,Susa M

    更新日期：2004-11-01 00:00:00

  • Bone mineral density of the total body and forearm in premenopausal black and white women.

    abstract：:This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(95)00050-n

    authors： Harris SS,Wood MJ,Dawson-Hughes B

    更新日期：1995-04-01 00:00:00

  • Objectively measured physical activity is associated with parameters of bone in 70-year-old men and women.

    abstract：:As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...

    journal_title：Bone

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.bone.2015.07.001

    authors： Johansson J,Nordström A,Nordström P

    更新日期：2015-12-01 00:00:00

  • Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.

    abstract：:Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115402

    authors： Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

    更新日期：2020-08-01 00:00:00

  • Three types of K(+) currents in murine osteocyte-like cells (MLO-Y4).

    abstract：:Osteocytes play an important role in signaling within bone. Communication of osteocytes with each other and with bone lining cells may have a function in mineral homeostasis and mechanotransduction. However, very little is known of the expression of ion channels in these cells. Using the whole-cell patch-clamp techniq...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(00)00439-7

    authors： Gu Y,Preston MR,El Haj AJ,Howl JD,Publicover SJ

    更新日期：2001-01-01 00:00:00

  • Effect of a general school-based physical activity intervention on bone mineral content and density: a cluster-randomized controlled trial.

    abstract：BACKGROUND:Specific physical loading leads to enhanced bone development during childhood. A general physical activity program mimicking a real-life situation was successful at increasing general physical health in children. Yet, it is not clear whether it can equally increase bone mineral mass. We performed a cluster-r...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2010.11.018

    authors： Meyer U,Romann M,Zahner L,Schindler C,Puder JJ,Kraenzlin M,Rizzoli R,Kriemler S

    更新日期：2011-04-01 00:00:00

  • Bone and muscle: Interactions beyond mechanical.

    abstract：:The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/j.bone.2015.02.010

    authors： Brotto M,Bonewald L

    更新日期：2015-11-01 00:00:00

  • The burden of fractures in Brazil: a population-based study.

    abstract：INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.04.002

    authors： Siqueira FV,Facchini LA,Hallal PC

    更新日期：2005-08-01 00:00:00

  • Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors.

    abstract：:Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00026-x

    authors： Kellenberger S,Muller K,Richener H,Bilbe G

    更新日期：1998-05-01 00:00:00

  • Further improvements on the factors affecting bone mineral density measured by quantitative micro-computed tomography.

    abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.10.004

    authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

    更新日期：2012-03-01 00:00:00

  • Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid.

    abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(94)00001-8

    authors： Sasaki T,Watanabe C

    更新日期：1995-01-01 00:00:00

  • Scoliosis in osteogenesis imperfecta caused by COL1A1/COL1A2 mutations - genotype-phenotype correlations and effect of bisphosphonate treatment.

    abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.02.018

    authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

    更新日期：2016-05-01 00:00:00

  • Effect of inducible bone morphogenetic protein 2 expression on the osteogenic differentiation of dental pulp stem cells in vitro.

    abstract：:Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) isolated from extracted third molar ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.115214

    authors： Tóth F,Gáll JM,Tőzsér J,Hegedűs C

    更新日期：2020-03-01 00:00:00

  • The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains.

    abstract：:Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluatio...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.06.024

    authors： Roberts BC,Giorgi M,Oliviero S,Wang N,Boudiffa M,Dall'Ara E

    更新日期：2019-10-01 00:00:00

  • Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways.

    abstract：:Interleukin (IL)-17 is crucial to osteoclast differentiation and activation. Osteocytes support osteoclast formation and are thought to orchestrate bone remodeling in response to fluid flow. The contribution of IL-17 to osteocyte-related bone resorption remains unclear. Here, we used the osteocyte-like MLO-Y4 cell lin...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.04.003

    authors： Liao C,Cheng T,Wang S,Zhang C,Jin L,Yang Y

    更新日期：2017-08-01 00:00:00

  • Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population.

    abstract：:Bone mineral density is under strong genetic control and polymorphisms of the vitamin D receptor (VDR) have been suggested to account for some of the genetic variation in bone mass. However, the relationship between VDR polymorphisms and bone density is controversial and has not been confirmed by all workers. Since th...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(95)00483-1

    authors： Houston LA,Grant SF,Reid DM,Ralston SH

    更新日期：1996-03-01 00:00:00

  • Effects of vitamin D3, 17beta-estradiol, vasoactive intestinal peptide, and glutamate on electric coupling between rat osteoblast-like cells in vitro.

    abstract：:Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00142-2

    authors： Schirrmacher K,Bingmann D

    更新日期：1998-12-01 00:00:00

  • Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification.

    abstract：:Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate chondrocytes could protect the calcification of en...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.06.018

    authors： Xu HG,Yu YF,Zheng Q,Zhang W,Wang CD,Zhao XY,Tong WX,Wang H,Liu P,Zhang XL

    更新日期：2014-09-01 00:00:00

  • Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application.

    abstract：:Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.05.010

    authors： Pauly S,Luttosch F,Morawski M,Haas NP,Schmidmaier G,Wildemann B

    更新日期：2009-09-01 00:00:00

  • Variation of the mineral density in cortical bone may serve to keep strain amplitudes within a physiological range.

    abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.04.026

    authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

    更新日期：2013-08-01 00:00:00

  • Intensity-related differences in collagen post-translational modification in MC3T3-E1 osteoblasts after exposure to low- and high-intensity pulsed ultrasound.

    abstract：:Low-intensity pulsed ultrasound (LIPUS) has distinct effects on biologic mineralization at intensities of <100 mW/cm2. Intensity-dependent differences in the pattern of accelerated mineralization may be due to different alterations in regulation of collagenous matrix formation. However, little is known about the influ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.04.024

    authors： Saito M,Soshi S,Tanaka T,Fujii K

    更新日期：2004-09-01 00:00:00

  • No loss of biomechanical effects after withdrawal of short-term PTH treatment in an aged, osteopenic, ovariectomized rat model.

    abstract：:The aim of the study was to assess the biomechanical effects of short-term PTH treatment and withdrawal on bone mass and strength in an aged, osteopenic, ovariectomized (ovx) rat model. Additionally, the effect of sequential therapy with PTH and the bisphosphonate, risedronate, the effect of longterm PTH monotherapy, ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(97)00024-0

    authors： Mosekilde L,Thomsen JS,McOsker JE

    更新日期：1997-05-01 00:00:00

  • Effects of recreational team handball on bone health, postural balance and body composition in inactive postmenopausal women - A randomised controlled trial.

    abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2021.115847

    authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

    更新日期：2021-01-13 00:00:00

  • Effect of gene dose and parental origin on bone histomorphometry in X-linked Hyp mice.

    abstract：:X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2003.09.004

    authors： Qiu ZQ,Travers R,Rauch F,Glorieux FH,Scriver CR,Tenenhouse HS

    更新日期：2004-01-01 00:00:00

  • Early detection of burn induced heterotopic ossification using transcutaneous Raman spectroscopy.

    abstract：INTRODUCTION:Heterotopic ossification (HO), or the abnormal formation of bone in soft tissue, occurs in over 60% of major burn injuries and blast traumas. A significant need exists to improve the current diagnostic modalities for HO which are inadequate to diagnose and intervene on HO at early time-points. Raman spectr...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.01.002

    authors： Peterson JR,Okagbare PI,De La Rosa S,Cilwa KE,Perosky JE,Eboda ON,Donneys A,Su GL,Buchman SR,Cederna PS,Wang SC,Kozloff KM,Morris MD,Levi B

    更新日期：2013-05-01 00:00:00

  • Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells.

    abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.08.020

    authors： Kulkarni RN,Voglewede PA,Liu D

    更新日期：2013-12-01 00:00:00