Bone mineral density of the total body and forearm in premenopausal black and white women.


:This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and more pregnancies and births, were younger at menarche, and reported lower alcohol intakes than the white women studied. A smaller percent of the black women had experienced amenorrhea, and a higher percent had lived at southern latitudes. Smoking history and lifetime use of oral contraceptives were similar in the two groups. Total body BMD, adjusted for body mass index (BMI), was 5.9% higher in the black than in the white women [mean +/- standard deviation (SD): 1.230 +/- 0.076 g/cm2 compared with 1.161 +/- 0.075; difference (95% confidence interval [CI95]: 0.068 (0.042, 0.095)]. Forearm BMD, adjusted for BMI, was 9.3% higher in the black women [mean +/- SD: 0.505 +/- 0.046 compared with 0.462 +/- 0.045; difference (CI95): 0.043 (0.027, 0.059)]. Adjustment for the other medical and lifestyle differences noted before had little effect on estimated BMD differences between the two groups.






Harris SS,Wood MJ,Dawson-Hughes B




Has Abstract


1995-04-01 00:00:00




4 Suppl












  • Effect of gene dose and parental origin on bone histomorphometry in X-linked Hyp mice.

    abstract::X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...


    pub_type: 杂志文章


    authors: Qiu ZQ,Travers R,Rauch F,Glorieux FH,Scriver CR,Tenenhouse HS

    更新日期:2004-01-01 00:00:00

  • Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

    abstract::Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesize...


    pub_type: 杂志文章


    authors: Perrier A,Dumas V,Linossier MT,Fournier C,Jurdic P,Rattner A,Vico L,Guignandon A

    更新日期:2010-07-01 00:00:00

  • Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats.

    abstract::The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in bone mass. Given the ability of tetracyclines to inhibit the breakdown of connective tissue collagen in experimental diabetes (and in other diseases), we examined...


    pub_type: 杂志文章


    authors: Bain S,Ramamurthy NS,Impeduglia T,Scolman S,Golub LM,Rubin C

    更新日期:1997-08-01 00:00:00

  • Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model.

    abstract::Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...


    pub_type: 杂志文章


    authors: Kosugi K,Tajima T,Menuki K,Okuma KF,Tokuda K,Fukuda H,Okada Y,Tsukamoto M,Yamanaka Y,Zenke Y,Sakai A

    更新日期:2020-07-01 00:00:00

  • Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors.

    abstract::Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...


    pub_type: 杂志文章


    authors: Kellenberger S,Muller K,Richener H,Bilbe G

    更新日期:1998-05-01 00:00:00

  • Subchondral tibial bone mineral density predicts future joint space narrowing at the medial femoro-tibial compartment in patients with knee osteoarthritis.

    abstract::Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...


    pub_type: 杂志文章


    authors: Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JY

    更新日期:2003-05-01 00:00:00

  • Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products.

    abstract::In this study we investigate bone metabolism in patients with rheumatoid arthritis (RA), with or without joint destruction, using serum biochemical markers of bone turnover. Three hundred eighteen patients (disease duration >2 years; mean 9 years) were divided into those with joint destruction, that is, with Larsen wr...


    pub_type: 杂志文章


    authors: Garnero P,Jouvenne P,Buchs N,Delmas PD,Miossec P

    更新日期:1999-04-01 00:00:00

  • Hyperphosphatemia with low FGF7 and normal FGF23 and sFRP4 levels in the circulation characterizes pediatric hypophosphatasia.

    abstract::Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...


    pub_type: 杂志文章


    authors: Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

    更新日期:2020-05-01 00:00:00

  • Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis.

    abstract::Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...


    pub_type: 杂志文章


    authors: Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

    更新日期:2000-05-01 00:00:00

  • Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.

    abstract:INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...


    pub_type: 杂志文章


    authors: Tenne M,McGuigan F,Jansson L,Gerdhem P,Obrant KJ,Luthman H,Akesson K

    更新日期:2008-04-01 00:00:00

  • A theoretical analysis of the contributions of remodeling space, mineralization, and bone balance to changes in bone mineral density during alendronate treatment.

    abstract::In patients with osteoporosis, alendronate treatment causes an increase in bone mineral density (BMD) and a decrease in fracture incidence. Alendronate acts by changing the bone remodeling process. Changes in bone remodeling resulting in decreased remodeling space, increased bone balance per remodeling cycle, and incr...


    pub_type: 杂志文章


    authors: Hernandez CJ,Beaupré GS,Marcus R,Carter DR

    更新日期:2001-12-01 00:00:00

  • Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity.

    abstract:PURPOSE:Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts is involved in the progression of osteoarthritis (OA). Human osteoblasts isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/ß-catenin pathway, and a reduced mine...


    pub_type: 杂志文章


    authors: Abed E,Bouvard B,Martineau X,Jouzeau JY,Reboul P,Lajeunesse D

    更新日期:2015-06-01 00:00:00

  • Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children.

    abstract::We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Specker B,Binkley T

    更新日期:2004-12-01 00:00:00

  • Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis.

    abstract::Bone loss represents a major unsolved problem in rheumatoid arthritis (RA). The skeletal complications of RA consist of focal bone erosions and periarticular osteoporosis at sites of active inflammation, and generalized bone loss with reduced bone mass. New evidence indicates that osteoclasts are key mediators of all ...


    pub_type: 杂志文章,评审


    authors: Romas E,Gillespie MT,Martin TJ

    更新日期:2002-02-01 00:00:00

  • Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP).

    abstract:BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...


    pub_type: 杂志文章


    authors: Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

    更新日期:2018-04-01 00:00:00

  • Reconstruction of the formative site in trabecular bone by a new, quick, and easy method.

    abstract::Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...


    pub_type: 杂志文章


    authors: Steiniche T,Eriksen EF,Kudsk H,Mosekilde L,Melsen F

    更新日期:1992-01-01 00:00:00

  • Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

    abstract::Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...


    pub_type: 杂志文章


    authors: Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

    更新日期:2020-09-01 00:00:00

  • ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation.

    abstract::ED-71, a novel analog of 1alpha,25-(OH)2 D3, increases bone mass to a greater extent than alfacalcidol, an 1alpha,25-(OH)2 D3 prodrug. In this study, we used a murine bone marrow ablation model to compare the effect of ED-71 on bone formation and resorption in vivo with that of 1alpha,25-(OH)2 D3. We discovered that b...


    pub_type: 杂志文章


    authors: Okuda N,Takeda S,Shinomiya K,Muneta T,Itoh S,Noda M,Asou Y

    更新日期:2007-02-01 00:00:00

  • Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid.

    abstract::To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...


    pub_type: 杂志文章


    authors: Sasaki T,Watanabe C

    更新日期:1995-01-01 00:00:00

  • Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein.

    abstract::Bone sialoprotein (BSP) is a multifunctional extracellular matrix protein found in mineralized tissues, including bone, cartilage, tooth root cementum (both acellular and cellular types), and dentin. In order to define the role BSP plays in the process of biomineralization of these tissues, we analyzed cementogenesis,...


    pub_type: 杂志文章


    authors: Foster BL,Ao M,Willoughby C,Soenjaya Y,Holm E,Lukashova L,Tran AB,Wimer HF,Zerfas PM,Nociti FH Jr,Kantovitz KR,Quan BD,Sone ED,Goldberg HA,Somerman MJ

    更新日期:2015-09-01 00:00:00

  • Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells.

    abstract::Fibrillin-containing microfibrils are structural components of extracellular matrices of a diverse range of tissues, including bone. Their importance in bone biology is illustrated by the skeletal abnormalities manifest in the congenital disorder, Marfan syndrome, which results from mutations in the fibrillin-1 gene. ...


    pub_type: 杂志文章


    authors: Kitahama S,Gibson MA,Hatzinikolas G,Hay S,Kuliwaba JL,Evdokiou A,Atkins GJ,Findlay DM

    更新日期:2000-07-01 00:00:00

  • Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits.

    abstract::We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...


    pub_type: 杂志文章


    authors: Suzuki K,Aoki K,Ohya K

    更新日期:1997-12-01 00:00:00

  • 22-Oxacalcitriol attenuates bone loss in nonobese type 2 diabetes.

    abstract::Active vitamin D is a major therapeutic agent for bone disease. Although some studies have reported that vitamin D ameliorates bone disease related to diabetes, the mechanism remains unclear. Our study investigated the effect of the vitamin D receptor activator 22-oxacalcitriol (OCT) on bone disease in a rat model of ...


    pub_type: 杂志文章


    authors: Goto S,Fujii H,Kono K,Nakai K,Awata R,Yonekura Y,Hirata M,Shinohara M,Nishi S,Fukagawa M

    更新日期:2015-05-01 00:00:00

  • Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children.

    abstract::Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein ...


    pub_type: 杂志文章


    authors: Braithwaite VS,Jones KS,Schoenmakers I,Silver M,Prentice A,Hennig BJ

    更新日期:2015-05-01 00:00:00

  • High bone turnover is associated with low bone mass in both pre- and postmenopausal women.

    abstract::In 979 healthy women, aged 30-75 years, bone mass was measured by DXA in the lumbar spine and proximal femur, and by SXA in the distal forearm. Bone turnover was assessed by urinary CrossLaps (CrossLaps ELISA), a new assay which measures type I collagen degradation products in urine and by osteocalcin (two-site N-Mid ...


    pub_type: 杂志文章


    authors: Ravn P,Fledelius C,Rosenquist C,Overgaard K,Christiansen C

    更新日期:1996-09-01 00:00:00

  • Hip structural geometry in old and old-old age: similarities and differences between men and women.

    abstract:INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...


    pub_type: 杂志文章


    authors: Yates LB,Karasik D,Beck TJ,Cupples LA,Kiel DP

    更新日期:2007-10-01 00:00:00

  • Biological apatite (BAp) crystallographic orientation and texture as a new index for assessing the microstructure and function of bone regenerated by tissue engineering.

    abstract::Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...


    pub_type: 杂志文章


    authors: Nakano T,Kaibara K,Ishimoto T,Tabata Y,Umakoshi Y

    更新日期:2012-10-01 00:00:00

  • Qualitative alterations of cortical bone in female rats after long-term administration of growth hormone and glucocorticoid.

    abstract::A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...


    pub_type: 杂志文章


    authors: Ortoft G,Oxlund H

    更新日期:1996-06-01 00:00:00

  • Positive association between the course of vitamin D intake and bone mineral density at 36 years in men.

    abstract:INTRODUCTION:Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of...


    pub_type: 杂志文章


    authors: van Dijk CE,de Boer MR,Koppes LL,Roos JC,Lips P,Twisk JW

    更新日期:2009-03-01 00:00:00

  • Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells.

    abstract::PEBP2alphaA/AML3/CBFA1 is one of the transcription regulators that belong to the PEBP2/AML family. The knockout mice, where the gene encoding PEBP2alphaA/AML3/CBFA1 was inactivated, showed no osteogenesis, indicating the critical role of this transcription factor in osteoblastic differentiation (Komori, Y. et al. Cell...


    pub_type: 杂志文章


    authors: Tsuji K,Ito Y,Noda M

    更新日期:1998-02-01 00:00:00