Bone mineral density of the total body and forearm in premenopausal black and white women.

abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

journal_title：Bone

authors： Minkoff JR,Grant BF,Marcus R

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) s...

journal_title：Bone

authors： Fassio A,Adami G,Benini C,Vantaggiato E,Saag KG,Giollo A,Lippolis I,Viapiana O,Idolazzi L,Orsolini G,Rossini M,Gatti D

更新日期：2019-06-01 00:00:00

abstract：:Paget's disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is the second most frequent bone disorder. PDB is a focal disorder affecting the skeleton segmentally but the cause of which is unknown. It has been hypothesised that somatic mutations could be responsible for the mosaicism described in...

journal_title：Bone

authors： Usategui-Martín R,Gutiérrez-Cerrajero C,Jiménez-Vázquez S,Calero-Paniagua I,García-Aparicio J,Corral-Gudino L,Del Pino-Montes J,González-Sarmiento R

更新日期：2018-07-01 00:00:00

abstract：:We investigated the role of 3,5,3'-tri-iodothyronine (T3) in regulating differentiation of osteoprogenitor cells and also studied the effects of the glucocorticoid hormone dexamethasone (Dex) on the T3-induced effects on osteoprogenitor populations. This was done by determining the effects of either hormone alone, or ...

journal_title：Bone

authors： Ishida H,Bellows CG,Aubin JE,Heersche JN

更新日期：1995-05-01 00:00:00

abstract：:We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using this coculture system, we examined the effects of c-fos antisens...

journal_title：Bone

authors： Udagawa N,Chan J,Wada S,Findlay DM,Hamilton JA,Martin TJ

更新日期：1996-06-01 00:00:00

abstract：:Osteocytes play an important role in signaling within bone. Communication of osteocytes with each other and with bone lining cells may have a function in mineral homeostasis and mechanotransduction. However, very little is known of the expression of ion channels in these cells. Using the whole-cell patch-clamp techniq...

journal_title：Bone

authors： Gu Y,Preston MR,El Haj AJ,Howl JD,Publicover SJ

更新日期：2001-01-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

更新日期：2020-05-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：:The risk of fragility fractures in elderly men is only partly explained by areal bone mineral density (aBMD) measured by dual X-ray absorptiometry (DXA). Several studies suggest the importance of bone morphology for the risk of fracture. The aim of this study was to assess the value of bone size and estimated structur...

journal_title：Bone

authors： Szulc P,Munoz F,Duboeuf F,Marchand F,Delmas PD

更新日期：2006-04-01 00:00:00

abstract：:Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...

journal_title：Bone

authors： McGee-Lawrence ME,Carpio LR,Bradley EW,Dudakovic A,Lian JB,van Wijnen AJ,Kakar S,Hsu W,Westendorf JJ

更新日期：2014-09-01 00:00:00

abstract：:Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....

journal_title：Bone

authors： Adami S,Felsenberg D,Christiansen C,Robinson J,Lorenc RS,Mahoney P,Coutant K,Schimmer RC,Delmas PD

更新日期：2004-05-01 00:00:00

abstract：:Immunosuppressant drugs are currently required by transplant recipients for the remainder of their lives, despite the many adverse effects associated with these therapies. Acute osteoporosis is one such effect, and a reproducible osteoporosis model has been established through the administration of the immunosuppressa...

journal_title：Bone

authors： Fukunaga J,Yamaai T,Yamachika E,Ishiwari Y,Tsujigiwa H,Sawaki K,Lee YJ,Ueno T,Kirino S,Mizukawa N,Takagi S,Nagai N,Sugahara T

更新日期：2004-03-01 00:00:00

abstract：:Due to the reduction in bone mass and deterioration in bone microarchitecture, osteoporosis is an important risk factor for impairing implant osseointegration. Recently, low-magnitude, high-frequency (LMHF) vibration (LM: <1×g; HF: 20-90Hz) has been shown to exhibit anabolic, but anti-resorptive effects on skeletal ho...

journal_title：Bone

authors： Zhou Y,Guan X,Liu T,Wang X,Yu M,Yang G,Wang H

更新日期：2015-02-01 00:00:00

abstract：:We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...

journal_title：Bone

authors： Ralston SH,Helfrich MH

更新日期：1999-05-01 00:00:00

abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...

journal_title：Bone

authors： Takahashi K,Tsuboyama T,Matsushita M,Kasai R,Okumura H,Yamamuro T,Okamoto Y,Kitagawa K,Takeda T

更新日期：1994-03-01 00:00:00

abstract：:Interstitial bone fluid flow (IBFF) is suggested as a communication medium that bridges external physical signals and internal cellular activities in the bone, which thus regulates bone remodeling. Intramedullary pressure (ImP) is one main regulatory factor of IBFF and bone adaptation related mechanotransduction. Our ...

journal_title：Bone

authors： Hu M,Cheng J,Bethel N,Serra-Hsu F,Ferreri S,Lin L,Qin YX

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

journal_title：Bone

authors： de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

更新日期：2021-01-07 00:00:00

abstract：:We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...

journal_title：Bone

authors： Suzuki K,Aoki K,Ohya K

更新日期：1997-12-01 00:00:00

abstract：:Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...

journal_title：Bone

authors： Di Fiore R,Marcatti M,Drago-Ferrante R,D'Anneo A,Giuliano M,Carlisi D,De Blasio A,Querques F,Pastore L,Tesoriere G,Vento R

更新日期：2014-03-01 00:00:00

abstract：:Bone is a highly dynamic organ in which several cell types function cooperatively. Among these, osteocytes have recently emerged as an important regulator of bone homeostasis, although their mechanism of regulation is unclear. Here, intravital bone imaging by two-photon excitation microscopy allowed us to directly vis...

journal_title：Bone

authors： Sano H,Kikuta J,Furuya M,Kondo N,Endo N,Ishii M

更新日期：2015-05-01 00:00:00

abstract：:During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...

journal_title：Bone

authors： Wallach S,Rousseau G,Martin L,Azria M

更新日期：1999-11-01 00:00:00

abstract：:The parathyroid hormone (PTH) signaling pathways that effect changes in osteoblast gene expression also alter the organization of the cytoskeletal proteins. PTH regulates the expression of nucleoskeletal proteins, such as nuclear mitotic apparatus protein (NuMA) and topoisomerase II-alpha. NuMA is a structural compone...

journal_title：Bone

authors： Torrungruang K,Feister H,Swartz D,Hancock EB,Hock J,Bidwell JP

更新日期：1998-04-01 00:00:00

abstract：:Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...

journal_title：Bone

authors： Sakai S,Endo K,Takeda S,Mihara M,Shiraishi A

更新日期：2012-05-01 00:00:00

abstract：:The ovariectomized (OVX) rat is a well established model for osteoporosis research. The recent development of in vivo micro-computed tomography (micro-CT) provides new possibilities to monitor individual bone changes over time. The purpose of this study was to establish the normal time course of bone loss in the OVX r...

journal_title：Bone

authors： Boyd SK,Davison P,Müller R,Gasser JA

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

journal_title：Bone

authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

更新日期：2006-08-01 00:00:00

abstract：:Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean ...

journal_title：Bone

authors： Schulte FA,Lambers FM,Webster DJ,Kuhn G,Müller R

更新日期：2011-12-01 00:00:00

abstract：:In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...

journal_title：Bone

authors： Grgurevic L,Erjavec I,Gupta M,Pecin M,Bordukalo-Niksic T,Stokovic N,Vnuk D,Farkas V,Capak H,Milosevic M,Bubic Spoljar J,Peric M,Vuckovic M,Maticic D,Windhager R,Oppermann H,Sampath TK,Vukicevic S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

journal_title：Bone

authors： Whitney DG,Devlin MJ,Alford AI,Caird MS

更新日期：2021-01-01 00:00:00

abstract：:The objective of the study was to assess the short- and long-term effects of adhesive capsulitis (frozen shoulder) on the bone mineral density (BMD) of the affected extremity. BMD and clinical status of 22 patients (group A) with active-phase unilateral adhesive capsulitis and 31 patients (group B) with a previous adh...

journal_title：Bone

authors： Leppälä J,Kannus P,Sievänen H,Järvinen M,Vuori I

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00