Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse.

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...

journal_title：Bone

authors： Lei SF,Wu S,Li LM,Deng FY,Xiao SM,Jiang C,Chen Y,Jiang H,Yang F,Tan LJ,Sun X,Zhu XZ,Liu MY,Liu YZ,Chen XD,Deng HW

更新日期：2009-05-01 00:00:00

abstract：:SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...

journal_title：Bone

authors： Lhaneche L,Hald JD,Domingues A,Hannouche D,Delepine M,Zelenika D,Boland A,Ostertag A,Cohen-Solal M,Langdahl BL,Harsløf T,de Vernejoul MC,Geoffroy V,Jehan F

更新日期：2016-11-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:Bone tissue undergoes permanent and lifelong remodeling with a concerted action of bone-building osteoblasts and bone-resorbing osteoclasts. A precise cooperation between those two cell types is critical in the complex process of bone renewal. Galectin-3 is a member of the β-galactoside-binding lectin family playing m...

journal_title：Bone

authors： Simon D,Derer A,Andes FT,Lezuo P,Bozec A,Schett G,Herrmann M,Harre U

更新日期：2017-12-01 00:00:00

abstract：:The osteoprotegerin (OPG)/receptor activator of NF-kappaB ligand (RANKL) axis is thought to be involved in the upregulation of bone turnover following sex steroid deficiency. Here, we investigated the effects of orchiectomy (ORX) on bone turnover and free soluble RANKL (sRANKL) in aged rats. Free, bioactive sRANKL is ...

journal_title：Bone

authors： Proell V,Xu H,Schüler C,Weber K,Hofbauer LC,Erben RG

更新日期：2009-10-01 00:00:00

abstract：:High doses of caffeine will induce calcium loss and influence the normal development of bone, whereas the proper exercise has positive effects on bone metabolism. This study investigated the possible effects of exercise to antagonize the caffeine-induced impairment of bone development in young male Wistar rats. A tota...

journal_title：Bone

authors： Huang TH,Yang RS,Hsieh SS,Liu SH

更新日期：2002-01-01 00:00:00

abstract：:Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...

journal_title：Bone

authors： Wiren KM,Zhang XW,Olson DA,Turner RT,Iwaniec UT

更新日期：2012-11-01 00:00:00

abstract：:Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...

journal_title：Bone

authors： Logan NJ,Camman M,Williams G,Higgins CA

更新日期：2018-12-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on...

journal_title：Bone

authors： Fahrleitner-Pammer A,Burr D,Dobnig H,Stepan JJ,Petto H,Li J,Krege JH,Pavo I

更新日期：2016-08-01 00:00:00

abstract：:Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma of bone and then treated animals with X-radiation therapy. We ...

journal_title：Bone

authors： Margulies BS,DeBoyace SD,Damron TA,Allen MJ

更新日期：2015-10-01 00:00:00

abstract：:The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoc...

journal_title：Bone

authors： Thacher TD,Pettifor JM,Tebben PJ,Creo AL,Skrinar A,Mao M,Chen CY,Chang T,San Martin J,Carpenter TO

更新日期：2019-05-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:The assay for the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) has been shown to reflect increased type I collagen degradation in such pathological conditions as bone metastases and rheumatoid arthritis, but to be rather insensitive to the changes in physiological bone collagen turnover (e.g., in...

journal_title：Bone

authors： Sassi ML,Eriksen H,Risteli L,Niemi S,Mansell J,Gowen M,Risteli J

更新日期：2000-04-01 00:00:00

abstract：:Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus....

journal_title：Bone

authors： Stegen S,van Gastel N,Carmeliet G

更新日期：2015-01-01 00:00:00

abstract：:Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...

journal_title：Bone

authors： Follak N,Klöting I,Wolf E,Merk H

更新日期：2004-07-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：:One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...

journal_title：Bone

authors： Allen MR,Iwata K,Phipps R,Burr DB

更新日期：2006-10-01 00:00:00

abstract：:Hypophosphatasia (HPP) is an inherited disorder characterized by defective bone mineralization caused by mutations in the alkaline phosphatase gene (ALPL). Clinically, the disease spans a great continuum of disease severity and six forms can be distinguished according to the age of onset. The most severe is the autoso...

journal_title：Bone

authors： Watanabe A,Satoh S,Fujita A,Naing BT,Orimo H,Shimada T

更新日期：2014-03-01 00:00:00

abstract：:Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...

journal_title：Bone

authors： Muschitz C,Kocijan R,Haschka J,Pahr D,Kaider A,Pietschmann P,Hans D,Muschitz GK,Fahrleitner-Pammer A,Resch H

更新日期：2015-10-01 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

journal_title：Bone

authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

更新日期：2021-02-01 00:00:00

abstract：:We have previously shown that the therapeutic range of ultrasound heals osteoradionecrotic bone and induces bone formation in vitro. It is well established that nitric oxide (NO) and prostaglandins are crucial early mediators in mechanically induced bone formation. The therapeutic range of ultrasound may act in the sa...

journal_title：Bone

authors： Reher P,Harris M,Whiteman M,Hai HK,Meghji S

更新日期：2002-07-01 00:00:00

abstract：:Osteoporosis is a common complex disorder with reduced bone mineral density (BMD) and increased susceptibility to fracture. Peak BMD is one of the primary determinants of osteoporotic fracture risk, and is under substantial genetic control. Extracellular matrix, a major component of the bone, influences BMD by regulat...

journal_title：Bone

authors： Alam I,Padgett LR,Ichikawa S,Alkhouli M,Koller DL,Lai D,Peacock M,Xuei X,Foroud T,Edenberg HJ,Econs MJ

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation ...

journal_title：Bone

authors： Han L,Yang X,Sun W,Li Z,Ren H,Li B,Zhang R,Zhang D,Shi Z,Liu J,Cao J,Zhang J,Xiong Y

更新日期：2018-12-01 00:00:00

abstract：:Bone homeostasis is regulated by a balance of bone formation and bone resorption; dysregulation of bone homeostasis may cause bone-related diseases (e.g., osteoporosis, osteopetrosis, bone fracture). Members of the nuclear factor of activated T cells (NFAT) family of transcription factors play crucial roles in the reg...

journal_title：Bone

authors： Kim HM,He L,Lee S,Park C,Kim DH,Han HJ,Han J,Hwang J,Cha-Molstad H,Lee KH,Ko SK,Jang JH,Ryoo IJ,Blenis J,Lee HG,Ahn JS,Kwon YT,Soung NK,Kim BY

更新日期：2020-02-01 00:00:00

abstract：:Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

journal_title：Bone

authors： Mallin MM,Pienta KJ,Amend SR

更新日期：2020-12-03 00:00:00

abstract：:Studies were carried out to characterize the effects of cyclosporines and FK506 on the formation and survival of osteoclasts deriving from mouse bone marrow cultures. Cyclosporin A (CsA), cyclosporin B (CsB), cyclosporin H (CsH), and FK506 all inhibited receptor activator of NFkappaB ligand (RANKL)-stimulated tartrate...

journal_title：Bone

authors： Igarashi K,Hirotani H,Woo JT,Stern PH

更新日期：2004-07-01 00:00:00

abstract：:The benefit of impact-loading activity for bone strength depends on whether the additional bone mineral content (BMC) accrued at loaded sites is due to an increased bone size, volumetric bone mineral density (vBMD) or both. Using magnetic resonance imaging (MRI) and dual energy X-ray absorptiometry (DXA), the aim of t...

journal_title：Bone

authors： Ducher G,Courteix D,Même S,Magni C,Viala JF,Benhamou CL

更新日期：2005-10-01 00:00:00

abstract：:Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of ...

journal_title：Bone

authors： Liu D,Li X,Li J,Yang J,Yokota H,Zhang P

更新日期：2015-12-01 00:00:00