Increased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation.

abstract：INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...

journal_title：Bone

authors： Jia J,Yao W,Amugongo S,Shahnazari M,Dai W,Lay YA,Olvera D,Zimmermann EA,Ritchie RO,Li CS,Alliston T,Lane NE

更新日期：2013-01-01 00:00:00

abstract：:The assay for the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) has been shown to reflect increased type I collagen degradation in such pathological conditions as bone metastases and rheumatoid arthritis, but to be rather insensitive to the changes in physiological bone collagen turnover (e.g., in...

journal_title：Bone

authors： Sassi ML,Eriksen H,Risteli L,Niemi S,Mansell J,Gowen M,Risteli J

更新日期：2000-04-01 00:00:00

abstract：:Mandibular condylar cartilage can be distinguished from articular and growth cartilages of long bones based on several differences in morphology, physiology, and function between these structures. However, there is almost no information available on the types of genes that contribute to these differences. In this stud...

journal_title：Bone

authors： Watahiki J,Yamaguchi T,Enomoto A,Irie T,Yoshie K,Tachikawa T,Maki K

更新日期：2008-06-01 00:00:00

abstract：:Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...

journal_title：Bone

authors： Olson EJ,Lindgren BR,Carlson CS

更新日期：2007-08-01 00:00:00

abstract：:The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...

journal_title：Bone

authors： Kanis JA

更新日期：1995-08-01 00:00:00

abstract：:In 979 healthy women, aged 30-75 years, bone mass was measured by DXA in the lumbar spine and proximal femur, and by SXA in the distal forearm. Bone turnover was assessed by urinary CrossLaps (CrossLaps ELISA), a new assay which measures type I collagen degradation products in urine and by osteocalcin (two-site N-Mid ...

journal_title：Bone

authors： Ravn P,Fledelius C,Rosenquist C,Overgaard K,Christiansen C

更新日期：1996-09-01 00:00:00

abstract：:This study aimed to explore the relationships of several indicators of cigarette smoking habits (smoking status, pack-years, age at smoking initiation and smoking cessation) with quantitative computed tomographic (QCT)-derived proximal femur bone measures (trabecular vBMD, integral vBMD and the ratio of cortical to to...

journal_title：Bone

authors： Marques EA,Elbejjani M,Gudnason V,Sigurdsson G,Lang T,Sigurdsson S,Aspelund T,Siggeirsdottir K,Launer L,Eiriksdottir G,Harris TB

更新日期：2018-03-01 00:00:00

abstract：:Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act as Wnt inhibitors. Small molecule tankyrase inhibitors are being inve...

journal_title：Bone

authors： Fujita S,Mukai T,Mito T,Kodama S,Nagasu A,Kittaka M,Sone T,Ueki Y,Morita Y

更新日期：2018-01-01 00:00:00

abstract：:To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...

journal_title：Bone

authors： Bjarnason NH,Bjarnason K,Hassager C,Christiansen C

更新日期：1997-02-01 00:00:00

abstract：:Endochondral ossification in the growth plate of long bones involves cartilage mineralization, bone formation and the budding vasculature. Many of these processes take place in a complex and dynamic zone, the provisional ossification zone, of the growth plate. Here we investigate aspects of mineralization in 2D and 3D...

journal_title：Bone

authors： Haimov H,Shimoni E,Brumfeld V,Shemesh M,Varsano N,Addadi L,Weiner S

更新日期：2020-01-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...

journal_title：Bone

authors： Armstrong ME,Cairns BJ,Banks E,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

更新日期：2012-06-01 00:00:00

abstract：:The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...

journal_title：Bone

authors： Roberts SJ,van Gastel N,Carmeliet G,Luyten FP

更新日期：2015-01-01 00:00:00

abstract：:The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...

journal_title：Bone

authors： Okumura H,Yamamuro T,Kasai R,Hayashi T,Tada K,Nishii Y

更新日期：1987-01-01 00:00:00

abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...

journal_title：Bone

authors： Lepola V,Jalovaara P,Väänänen K

更新日期：1994-05-01 00:00:00

abstract：:Bone remodeling is a process involving both dynamic and static bone strain. Although there exist numerous studies on the effect of dynamic strain on implant stability and bone remodeling, the effect of static strain has yet to be clarified. Hence, for this purpose, the effect of static bone strain on implant stability...

journal_title：Bone

authors： Halldin A,Jimbo R,Johansson CB,Wennerberg A,Jacobsson M,Albrektsson T,Hansson S

更新日期：2011-10-01 00:00:00

abstract：:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...

journal_title：Bone

authors： Lucke M,Wildemann B,Sadoni S,Surke C,Schiller R,Stemberger A,Raschke M,Haas NP,Schmidmaier G

更新日期：2005-05-01 00:00:00

abstract：INTRODUCTION:Spinal mobilization is commonly used in the treatment of patients with back pain, including individuals with osteoporosis. Previous data indicated that traditional predictors of skeletal failure-lateral or anteroposterior bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) or geometry of t...

journal_title：Bone

authors： Sran MM,Boyd SK,Cooper DM,Khan KM,Zernicke RF,Oxland TR

更新日期：2007-03-01 00:00:00

abstract：:To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg of eldecalcitol, and sham-operated animals rece...

journal_title：Bone

authors： de Freitas PH,Hasegawa T,Takeda S,Sasaki M,Tabata C,Oda K,Li M,Saito H,Amizuka N

更新日期：2011-09-01 00:00:00

abstract：:We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...

journal_title：Bone

authors： Specker B,Binkley T

更新日期：2004-12-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

journal_title：Bone

authors： Martin RB,Zissimos SL

更新日期：1991-01-01 00:00:00

abstract：:Results in small patient series suggest that cyclical intravenous treatment with pamidronate can lead to reshaping of compressed vertebral bodies in children and adolescents with osteogenesis imperfecta (OI), but more detailed analyses are lacking. In this study of patients with moderate to severe OI (age range 0.1 to...

journal_title：Bone

authors： Land C,Rauch F,Munns CF,Sahebjam S,Glorieux FH

更新日期：2006-10-01 00:00:00

abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

journal_title：Bone

authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

更新日期：2012-03-01 00:00:00

abstract：:E-Series prostaglandins (PGE) are powerful osteogenic substances when given in vivo. The purpose of this work was to determine the ability of locally administered PGE1 to promote alveolar bone formation. Controlled-release pellets containing PGE1 were implanted on the lateral mandibular surface of Beagle dogs and tiss...

journal_title：Bone

authors： Miller SC,Marks SC Jr

更新日期：1993-05-01 00:00:00

abstract：:The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...

journal_title：Bone

authors： Catherwood BD,Marcus R,Madvig P,Cheung AK

更新日期：1985-01-01 00:00:00

abstract：:The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...

journal_title：Bone

authors： Brotto M,Bonewald L

更新日期：2015-11-01 00:00:00

abstract：:Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...

journal_title：Bone

authors： Kannus P,Palvanen M,Niemi S,Sievänen H,Parkkari J

更新日期：2009-04-01 00:00:00

abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...

journal_title：Bone

authors： Cheung WY,Simmons CA,You L

更新日期：2012-01-01 00:00:00

abstract：:There are those who advocate nonoperative treatment of impacted femoral neck fractures, but in general there is consensus that surgery is the treatment of choice for both trochanteric hip fracture and femoral neck fracture. As for trochanteric fractures, modern results after internal fixation are characterized by only...

journal_title：Bone

authors： Obrant K

更新日期：1996-03-01 00:00:00