Abstract:
:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally versus systemically applied gentamicin in a rat model (n = 60). For local application, the antibiotic was delivered from a biodegradable poly(D,L-lactide) (PDLLA) coating of titanium implants. The efficacy of local prophylaxis was compared to a systemic single shot application of gentamicin as well as a combination of both administrations. Half of the animals received a weight-adopted single shot application of gentamicin 30 min prior to surgery. At surgery, the medullary cavities of the tibiae were contaminated with Staphylococcus aureus (10(2) colony forming units /CFU) and titanium Kirschner wires were implanted into the medullary canals. The implants were either uncoated, PDLLA coated, or coated with PDLLA + 10% w/w gentamicin. The animals were followed up for 42 days. X-ray examinations were performed; body weight, temperature, and the clinical condition were determined. After sacrifice, infection was evaluated by histological and microbiological analysis. All animals treated with uncoated or PDLLA-coated Kirschner wires without systemic application of the antibiotic developed osteomyelitis and all cultures of implants were tested positive on S. aureus. Implant-related osteomyelitis could be prevented by prophylaxis of systemically applied gentamicin in 15% of animals. In contrast, local application of gentamicin delivered from a PDLLA coating was more effective. Onset of infection could be prevented in 90% of animals treated with gentamicin coated Kirschner wires, and in 80% of the animals that were treated with a combination of local and systemic application. The local application from PDLLA-coated implants might support systemic antibiotic prophylaxis in preventing implant-associated osteomyelitis.
journal_name
Bonejournal_title
Boneauthors
Lucke M,Wildemann B,Sadoni S,Surke C,Schiller R,Stemberger A,Raschke M,Haas NP,Schmidmaier Gdoi
10.1016/j.bone.2005.01.008subject
Has Abstractpub_date
2005-05-01 00:00:00pages
770-8issue
5eissn
8756-3282issn
1873-2763pii
S8756-3282(05)00005-0journal_volume
36pub_type
杂志文章相关文献
BONE文献大全abstract::Bone structure is an important determinant of osteoporotic fracture. In women, bone structure is highly heritable, and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed at establishing the heritability of bone structure at the proximal femur, identi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.05.005
更新日期:2005-10-01 00:00:00
abstract::Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.09.012
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.019
更新日期:2019-06-01 00:00:00
abstract::We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(95)00249-9
更新日期:1995-10-01 00:00:00
abstract::A 57 year old white male with oncogenous osteomalacia due to a mixed mesenchymal tumor was evaluated by sequential histologic and metabolic studies over a period of 33 mos prior to identifying the location of the tumor. On the basis of these studies we conclude: (i) disorders of the enterohepatic circulation and/or ac...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90025-7
更新日期:1988-01-01 00:00:00
abstract::Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::The multi-domain neutral endopeptidase, ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin repeats) is induced by parathyroid hormone (PTH) in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling. However, its function(s) in bone cells have not been studied. Her...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.187
更新日期:2007-08-01 00:00:00
abstract::Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.014
更新日期:2010-10-01 00:00:00
abstract::Fibrillin-containing microfibrils are structural components of extracellular matrices of a diverse range of tissues, including bone. Their importance in bone biology is illustrated by the skeletal abnormalities manifest in the congenital disorder, Marfan syndrome, which results from mutations in the fibrillin-1 gene. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00292-1
更新日期:2000-07-01 00:00:00
abstract::In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.025
更新日期:2010-05-01 00:00:00
abstract::Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115436
更新日期:2020-08-01 00:00:00
abstract::The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2014.08.007
更新日期:2015-01-01 00:00:00
abstract::The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/8756-3282(93)90349-f
更新日期:1993-01-01 00:00:00
abstract::Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue durin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90087-f
更新日期:1990-01-01 00:00:00
abstract:AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.11.019
更新日期:2006-06-01 00:00:00
abstract::Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.008
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Prior research on the ability of bisphosphonates to prevent fractures and related health care utilization has been based on high levels of compliance achievable in clinical trial settings. This study was undertaken to assess rates of osteoporotic fractures and health care utilization as a function of bisphos...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.07.009
更新日期:2007-11-01 00:00:00
abstract::Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2009.09.028
更新日期:2010-02-01 00:00:00
abstract::The signals that allow bone to adapt to its mechanical environment most likely involve strain-mediated fluid flow through the canalicular channels. Fluid can only be moved through bone by cyclic loading, and the shear stresses generated on bone cells are proportional to the rate of loading. The proportional relation b...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(02)00707-x
更新日期:2002-05-01 00:00:00
abstract::Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.10.007
更新日期:2006-04-01 00:00:00
abstract::Immobilization leads to rapid loss of bone mass and mechanical competence, and long-term immobilization or repeated periods of short-term immobilization can have serious skeletal consequences and may lead to increased fracture liability. The aim of the present preclinical study was, therefore, to assess whether two an...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00375-6
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:U.S. Army Basic Combat Training (BCT) is a physically-demanding program at the start of military service. Whereas animal studies have shown that increased mechanical loading rapidly alters bone structure, there is limited evidence of changes in bone density and structure in humans exposed to a brief period o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.04.021
更新日期:2018-08-01 00:00:00
abstract::A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90316-3
更新日期:1985-01-01 00:00:00
abstract::Pregnancy is a common physiological event that could affect peak bone mass and the risk of developing osteoporosis later in life. There have been few longitudinal studies over a complete reproductive cycle of any size to show whether bone mineral density (BMD) changes. We have measured BMD by dual-energy X-ray absorpt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00017-6
更新日期:2003-04-01 00:00:00
abstract::We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...
journal_title:Bone
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.bone.2004.12.014
更新日期:2005-03-01 00:00:00
abstract::Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/8756-3282(96)88871-5
更新日期:1996-08-01 00:00:00
abstract:INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115756
更新日期:2021-02-01 00:00:00
abstract::Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.111
更新日期:2012-11-01 00:00:00
abstract::Increased levels of reactive oxygen species (ROS) are a crucial pathogenic factor of osteoporosis. Gastrodin, isolated from the traditional Chinese herbal agent Gastrodia elata, is a potent antioxidant. We hypothesized that gastrodin demonstrates protective effects against osteoporosis by partially reducing reactive o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.059
更新日期:2015-04-01 00:00:00
abstract::Numerous studies have investigated the effects of physical activity on bone health; however, little is known about the effects of isokinetic strength training on bone. While bone mineral density (BMD) is widely used to assess bone health and fracture risk, there are several limitations of this measure that warrant new...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.07.004
更新日期:2007-10-01 00:00:00