Abstract:
:We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently in 1992-1994. At each examination, bone mass was measured at the calcaneus and distal and proximal radius. The women had low average dietary calcium intakes (median intake 384 mg/day). Women taking calcium supplements reported a median supplement intake of 355 mg/day; over 75% of the women taking estrogen took the equivalent of 0.6 mg/day or more of conjugated estrogens. Women taking estrogen had uniformly slower bone loss at all three sites. Compared to women not taking estrogen, whose bone loss averaged about 1% per year, women taking estrogen had 0.75-0.85% per year decreased bone loss at the three bone sites. By contrast, women who stopped estrogen had greater than average loss rates (0.35-0.65% per year greater). Calcium supplementation also reduced bone loss, but to a lesser extent than estrogen: bone loss decreased 0.25% per year at the radius sites, but was not slowed at the calcaneus. The calcaneus is more trabecular than the radius sites, which may explain the lack of response. We also examined combined estrogen and calcium supplement use.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Bonejournal_title
Boneauthors
Davis JW,Ross PD,Johnson NE,Wasnich RDdoi
10.1016/s8756-3282(95)00249-9subject
Has Abstractpub_date
1995-10-01 00:00:00pages
369-73issue
4eissn
8756-3282issn
1873-2763pii
S8756328295002499journal_volume
17pub_type
杂志文章相关文献
BONE文献大全abstract::Osteocytes, the most abundant cells in the cortical bone matrix, are thought to have mechanosensory and chemosensory regulatory roles. Marotti theorized that osteocytes signal to osteoblasts to recruit them into the osteocyte lineage. Martin extended this theory, assuming that osteocytes display a general inhibitory e...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00245-x
更新日期:2003-11-01 00:00:00
abstract::The genetic influences on bone mass likely change throughout the life span, but most genetic studies of bone mass regulation have focused on adults. There is, however, a growing awareness of the importance of genes influencing the acquisition of bone mass during childhood on lifelong bone health. The present investiga...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.09.015
更新日期:2007-02-01 00:00:00
abstract::Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.021
更新日期:2014-03-01 00:00:00
abstract::One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.017
更新日期:2011-05-01 00:00:00
abstract::Bone loss represents a major unsolved problem in rheumatoid arthritis (RA). The skeletal complications of RA consist of focal bone erosions and periarticular osteoporosis at sites of active inflammation, and generalized bone loss with reduced bone mass. New evidence indicates that osteoclasts are key mediators of all ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(01)00682-2
更新日期:2002-02-01 00:00:00
abstract::One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.04.028
更新日期:2006-10-01 00:00:00
abstract::Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00135-z
更新日期:1995-07-01 00:00:00
abstract::To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(96)00335-3
更新日期:1997-02-01 00:00:00
abstract::E-Series prostaglandins (PGE) are powerful osteogenic substances when given in vivo. The purpose of this work was to determine the ability of locally administered PGE1 to promote alveolar bone formation. Controlled-release pellets containing PGE1 were implanted on the lateral mandibular surface of Beagle dogs and tiss...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90198-j
更新日期:1993-05-01 00:00:00
abstract:INTRODUCTION:The structure of trabecular bone represents an aspect of bone properties that affects vertebral bone strength independently of bone mineral density [M. Kleerekoper, A. Villanueva, J. Stanciu, D. Rao, and A. Parfitt. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral co...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.08.131
更新日期:2009-01-01 00:00:00
abstract::FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.09.021
更新日期:2005-02-01 00:00:00
abstract::Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00301-3
更新日期:1998-04-01 00:00:00
abstract::Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/8756-3282(96)88871-5
更新日期:1996-08-01 00:00:00
abstract::The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.020
更新日期:2012-07-01 00:00:00
abstract::Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00084-2
更新日期:1998-08-01 00:00:00
abstract::The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00194-i
更新日期:1995-08-01 00:00:00
abstract::High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS D...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2012.10.021
更新日期:2013-01-01 00:00:00
abstract::Clinically, osteopenia or low bone mass has been observed in a variety of chronic inflammatory diseases, and elevated proinflammatory mediators have implicated this process. The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation. Time-release pellets designed to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.008
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:High-resolution peripheral quantitative computed tomography (HR-pQCT) represents a three-dimensional tool for the screening of osteoporosis patients i.e., regarding fracture risk. The purpose of this study was to determine the baseline and follow-up bone microarchitecture in relation to incident fracture ris...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.06.022
更新日期:2018-09-01 00:00:00
abstract::To determine osteocalcin (OC) and adipokines in type 1 diabetes (T1D) and healthy controls, and to explore possible associations between glucose and bone metabolism, body composition and adipokines. Serum levels of total OC, undercarboxylated (UC-OC), leptin, adiponectin, and other parameters of glucose and bone metab...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.017
更新日期:2016-01-01 00:00:00
abstract::Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.03.672
更新日期:2011-06-01 00:00:00
abstract::Numerous studies have investigated the effects of physical activity on bone health; however, little is known about the effects of isokinetic strength training on bone. While bone mineral density (BMD) is widely used to assess bone health and fracture risk, there are several limitations of this measure that warrant new...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.07.004
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND AIM:Bone mineral density (BMD) is under strong genetic regulation, but it is not clear which genes are involved in the regulation, particularly in Asian populations. This study sought to determine the association between 29 genes discovered by Caucasian-based genome-wide association studies and BMD in a ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.03.003
更新日期:2015-07-01 00:00:00
abstract::Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.041
更新日期:2013-05-01 00:00:00
abstract::In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cell...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00660-3
更新日期:2002-01-01 00:00:00
abstract::We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.10.018
更新日期:2007-04-01 00:00:00
abstract::Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.06.007
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the experimental anterior cruciate ligament (ACL) dog model of osteoarthritis (OA) and analyze concomitant changes in the level of MMP-13 and cathepsin K, as well as examine the therapeutic effects of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.11.021
更新日期:2004-03-01 00:00:00
abstract::Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain. The glycosylated B chain binds specifically to galactose moieties of sugar molecules. In this study we showed that the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.02.018
更新日期:2011-06-01 00:00:00
abstract::The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115360
更新日期:2020-07-01 00:00:00