Abstract：
:E-Series prostaglandins (PGE) are powerful osteogenic substances when given in vivo. The purpose of this work was to determine the ability of locally administered PGE1 to promote alveolar bone formation. Controlled-release pellets containing PGE1 were implanted on the lateral mandibular surface of Beagle dogs and tissues collected 4 weeks later. There was a dose-related increase in alveolar bone thickness and bone formation rates following PGE1 administration. In many cases, there was substantial new bone formation on the alveolar crest. Some increase in alveolar bone remodeling occurred with higher doses of PGE1. These results demonstrate that locally administered PGE1 may be useful for the augmentation of alveolar bone.
journal_name
Bonejournal_title
Boneauthors
Miller SC,Marks SC Jrdoi
10.1016/8756-3282(93)90198-jsubject
Has Abstractpub_date
1993-05-01 00:00:00pages
587-93issue
3eissn
8756-3282issn
1873-2763pii
8756-3282(93)90198-Jjournal_volume
14pub_type
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