Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption.

abstract：:Feral adult female cynomolgus monkeys were divided into three groups and treated for two years: (1) normal controls; (2) weak androgenic treatment (androstenedione+estrone); and (3) strong androgenic treatment (testosterone). The tibiae and the trabecular bone of femoral head from each group were tested mechanically. ...

journal_title：Bone

authors： Kasra M,Grynpas MD

更新日期：1995-09-01 00:00:00

abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...

journal_title：Bone

authors： Sasaki T,Watanabe C

更新日期：1995-01-01 00:00:00

abstract：:To examine the ability of tamoxifen (TAM) to conserve bone in the estrogen-deficient ovariectomized (OVX) rat in the presence and absence of parathyroid hormone (PTH) six groups of rats with 45Ca-labeled bones were studied for 12 weeks. Rats were OVX, parathyroidectomized (PTX), or given sham operations and treated wi...

journal_title：Bone

authors： Goulding A,Gold E

更新日期：1994-09-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：:The parathyroid hormone (PTH) signaling pathways that effect changes in osteoblast gene expression also alter the organization of the cytoskeletal proteins. PTH regulates the expression of nucleoskeletal proteins, such as nuclear mitotic apparatus protein (NuMA) and topoisomerase II-alpha. NuMA is a structural compone...

journal_title：Bone

authors： Torrungruang K,Feister H,Swartz D,Hancock EB,Hock J,Bidwell JP

更新日期：1998-04-01 00:00:00

abstract：:Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...

journal_title：Bone

authors： Martyn-St James M,Carroll S

更新日期：2008-09-01 00:00:00

abstract：:Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...

journal_title：Bone

authors： El-Hajj Fuleihan G,Baddoura R,Awada H,Salam N,Salamoun M,Rizk P

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...

journal_title：Bone

authors： Alberts Z,Fewtrell M,Nicholls DE,Biassoni L,Easty M,Hudson LD

更新日期：2020-05-01 00:00:00

abstract：:Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein ...

journal_title：Bone

authors： Braithwaite VS,Jones KS,Schoenmakers I,Silver M,Prentice A,Hennig BJ

更新日期：2015-05-01 00:00:00

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

journal_title：Bone

authors： Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...

journal_title：Bone

authors： Jia J,Yao W,Amugongo S,Shahnazari M,Dai W,Lay YA,Olvera D,Zimmermann EA,Ritchie RO,Li CS,Alliston T,Lane NE

更新日期：2013-01-01 00:00:00

abstract：:Exercise during growth can be important for attaining optimal bone mass. High-intensity long-duration protocols, however, can have detrimental effects on immature bone morphology and mechanics. The underlying mechanisms are poorly understood. Here, we quantified the mechanical environment of the middiaphyseal rooster ...

journal_title：Bone

authors： Judex S,Zernicke RF

更新日期：2000-02-01 00:00:00

abstract：:Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...

journal_title：Bone

authors： Uttarilli A,Shah H,Bhavani GS,Upadhyai P,Shukla A,Girisha KM

更新日期：2019-03-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：:Little has been understood about vitamin D status in relation to bone health in Asian women. The purpose of this study was to identify how the serum 25-hydroxyvitamin D (25[OH]D) concentration is associated with bone mass and bone metabolism. This cross-sectional, community-based epidemiologic study was conducted amon...

journal_title：Bone

authors： Nakamura K,Tsugawa N,Saito T,Ishikawa M,Tsuchiya Y,Hyodo K,Maruyama K,Oshiki R,Kobayashi R,Nashimoto M,Yoshihara A,Ozaki R,Okano T,Yamamoto M

更新日期：2008-02-01 00:00:00

abstract：:Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...

journal_title：Bone

authors： Sakai S,Endo K,Takeda S,Mihara M,Shiraishi A

更新日期：2012-05-01 00:00:00

abstract：:Avian tibial dyschondroplasia is a disorder of endochondral ossification which results in the accumulation of noncalcified, avascular cartilage. We have investigated the changes in cell proliferation and enzyme activities within specific cell types in the growth plate of chickens with differing severity of the disease...

journal_title：Bone

authors： Farquharson C,Whitehead C,Rennie S,Thorp B,Loveridge N

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...

journal_title：Bone

authors： Rubin KH,Möller S,Choudhury A,Zorina O,Kalsekar S,Eriksen EF,Andersen M,Abrahamsen B

更新日期：2020-05-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...

journal_title：Bone

authors： Gasser JA

更新日期：1995-10-01 00:00:00

abstract：:Studies were carried out to characterize the effects of cyclosporines and FK506 on the formation and survival of osteoclasts deriving from mouse bone marrow cultures. Cyclosporin A (CsA), cyclosporin B (CsB), cyclosporin H (CsH), and FK506 all inhibited receptor activator of NFkappaB ligand (RANKL)-stimulated tartrate...

journal_title：Bone

authors： Igarashi K,Hirotani H,Woo JT,Stern PH

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:Angiogenesis is closely associated with bone formation, especially endochondral ossification. Angiopoietin 1 (Ang1) is a specific growth factor functioning to generate a stable and matured vasculature through the Tie2 receptor/PI3K/AKT pathway. Recently cartilage oligomeric matrix protein (COMP)-Ang1, an A...

journal_title：Bone

authors： Jeong BC,Kim HJ,Bae IH,Lee KN,Lee KY,Oh WM,Kim SH,Kang IC,Lee SE,Koh GY,Kim KK,Koh JT

更新日期：2010-02-01 00:00:00

abstract：:The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...

journal_title：Bone

authors： Søe K,Hobolt-Pedersen AS,Delaisse JM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...

journal_title：Bone

authors： Rousseau JC,Bertholon C,Chapurlat R,Szulc P

更新日期：2020-03-01 00:00:00

abstract：:Matrix vesicles (MVs) are membrane organelles found in the extracellular matrix of calcifying cells, which contain matrix processing enzymes and regulate the extracellular environment via action of these enzymes. It is unknown whether MVs are also exosomic mediators of cell-cell communication via transfer of RNA mater...

journal_title：Bone

authors： Lin Z,Rodriguez NE,Zhao J,Ramey AN,Hyzy SL,Boyan BD,Schwartz Z

更新日期：2016-07-01 00:00:00

abstract：:Bone homeostasis is regulated by a balance of bone formation and bone resorption; dysregulation of bone homeostasis may cause bone-related diseases (e.g., osteoporosis, osteopetrosis, bone fracture). Members of the nuclear factor of activated T cells (NFAT) family of transcription factors play crucial roles in the reg...

journal_title：Bone

authors： Kim HM,He L,Lee S,Park C,Kim DH,Han HJ,Han J,Hwang J,Cha-Molstad H,Lee KH,Ko SK,Jang JH,Ryoo IJ,Blenis J,Lee HG,Ahn JS,Kwon YT,Soung NK,Kim BY

更新日期：2020-02-01 00:00:00

abstract：:We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...

journal_title：Bone

authors： Ralston SH,Helfrich MH

更新日期：1999-05-01 00:00:00