Abstract:
:Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western world. However, subjects have not been randomly selected or systematically screened to rule out secondary causes of bone loss. The purpose of this study was to determine peak bone mass and lifestyle risk factors for bone loss in a randomly chosen sample of healthy Lebanese subjects from the greater Beirut area. Subjects 25-35 years of age were randomly selected from greater Beirut, which comprises one third of the Lebanese at large, and studied during the Fall of 1999. BMD was measured at the lumbar spine, hip, forearm, and total body. A questionnaire on lifestyle factors was administered to all subjects. Results were compared with the database of subjects from the USA provided by the manufacturer, and to the NHANES database for the total hip. Two hundred thirteen subjects were studied; 45 subjects rotated at all three centers for cross-calibration purposes. Peak BMD in Lebanese subjects was 0.2-0.9 SD below that of peak BMD in American subjects, depending on skeletal site, gender, and densitometer. These differences persisted after attempting to adjust for body size. Osteoporosis and osteopenia were more prevalent than in healthy young Americans. Height, weight, and total body fat were the most significant correlates of BMD/bone mineral content (BMC), accounting for 0.3-0.7 of the variance in bone mass measurement. Lifestyle factors had a very modest but significant contribution to bone mass variance. This is the first population-based study from the Middle East demonstrating that peak BMD is slightly lower in Lebanese subjects compared as with an established database from the USA. Due to the selection of relatively healthier subjects in our study than in the NHANES study, the actual differences between the two populations may be even greater. The impact of our findings on the epidemiology of osteoporotic fractures in Lebanon remains to be determined.
journal_name
Bonejournal_title
Boneauthors
El-Hajj Fuleihan G,Baddoura R,Awada H,Salam N,Salamoun M,Rizk Pdoi
10.1016/s8756-3282(02)00845-1subject
Has Abstractpub_date
2002-10-01 00:00:00pages
520-8issue
4eissn
8756-3282issn
1873-2763pii
S8756328202008451journal_volume
31pub_type
临床试验,杂志文章相关文献
BONE文献大全abstract:BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.01.014
更新日期:2019-04-01 00:00:00
abstract::LMP1 is an intracellular scaffold protein that contains a PDZ domain and three LIM domains. LMP1 has multiple functions including regulating mesenchymal stem cell (MSC) osteogenesis. Gene delivery of LMP1 induces bone formation in vivo in heterotopic and orthotopic sites. However, little is known about the physiologic...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.013
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115508
更新日期:2020-09-01 00:00:00
abstract::The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00148-8
更新日期:1997-10-01 00:00:00
abstract::The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00676-7
更新日期:2002-02-01 00:00:00
abstract::Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.027
更新日期:2019-06-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) can self-renew and differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. It's reported that bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic BMPs to initiate the commitment of MSCs to osteoblast lineage. Cyclooxygenase-2 (COX-2) is critical...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.08.015
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic kidney disease (CKD) is commonly associated with mineral and bone metabolism disorders, but these are less frequently studied in non-dialysis CKD patients than in dialysis patients. We examined and described international variation in mineral and bone disease (MBD) markers and their tr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115058
更新日期:2019-12-01 00:00:00
abstract::Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00084-2
更新日期:1998-08-01 00:00:00
abstract::Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.001
更新日期:2015-05-01 00:00:00
abstract::In the development of 3-dimensional cell-polymer matrices for tissue engineering, the ability of osteoblast cells to maintain their phenotypic properties and form a mineralized matrix while seeded on the polymer surface is very important. Osteoblast cell differentiation and bone formation using rat calvaria cells were...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00132-9
更新日期:1996-07-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:Diagnosis of prevalent osteoporotic vertebral fracture is complicated by normal or developmental variation in vertebral shape or size and non-osteoporotic deformities that appear to have 'reduced' height. Using our visual approach, the algorithm-based qualitative method (ABQ) a vertebra with...
journal_title:Bone
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.bone.2007.03.015
更新日期:2007-07-01 00:00:00
abstract::The skeleton is characterized by anatomic heterogeneity of metabolic turnover. Site-dependent differences in hormonal effects seem likely. Hyporesponsiveness of osteoclasts to parathyroid hormone (PTH) and probably calcitriol was recently demonstrated in the fifth lumbar vertebra of a rat model with moderate renal fai...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00502-6
更新日期:2001-09-01 00:00:00
abstract::Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...
journal_title:Bone
pub_type: 杂志文章,meta分析
doi:10.1016/j.bone.2008.05.012
更新日期:2008-09-01 00:00:00
abstract::Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90400-4
更新日期:1985-01-01 00:00:00
abstract::Low-intensity pulsed ultrasound (LIPUS) has distinct effects on biologic mineralization at intensities of <100 mW/cm2. Intensity-dependent differences in the pattern of accelerated mineralization may be due to different alterations in regulation of collagenous matrix formation. However, little is known about the influ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.04.024
更新日期:2004-09-01 00:00:00
abstract::Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00083-6
更新日期:1999-06-01 00:00:00
abstract::Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.04.006
更新日期:2004-09-01 00:00:00
abstract:CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2021.115841
更新日期:2021-01-06 00:00:00
abstract::Although low bone mineral density (BMD) is strongly associated with increased fracture risk, up to 50% of those who suffer fractures are not detected as high-risk patients by BMD testing. Thus, new approaches may improve identification of those at increased risk for fracture by in vivo assessment of altered bone tissu...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.03.021
更新日期:2018-01-01 00:00:00
abstract::Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00026-x
更新日期:1998-05-01 00:00:00
abstract::Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.036
更新日期:2019-06-01 00:00:00
abstract::Many osteoporotic fracture patients are candidates for concurrent treatment with bisphosphonates and bioceramic bone graft substitutes. Osteopromotive silica-based bioactive glasses are known to induce accelerated local bone turnover and adjunct antiresorptive agents, such as zoledronic acid, may affect the process. T...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.016
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Several epidemiological studies have shown an association between bone mineral density (BMD) and risk of breast cancer in postmenopausal women, but it remains unknown whether bone turnover is associated with increased risk of cancer. The aim of this study was to investigate if markers of bone formation and r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.05.032
更新日期:2019-10-01 00:00:00
abstract::Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.06.014
更新日期:2016-09-01 00:00:00
abstract::The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.07.013
更新日期:2014-10-01 00:00:00
abstract::Sclerostin monoclonal antibody (Scl-Ab) has been shown to increase bone mass and bone strength by stimulating bone formation in an ovariectomy-induced bone loss rat model. The purpose of this study was to determine the effects of Scl-Ab in a rat immobilization/disuse model in which there was both a decrease in bone fo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.09.009
更新日期:2011-02-01 00:00:00
abstract::Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90018-x
更新日期:1988-01-01 00:00:00
abstract::SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.004
更新日期:2016-11-01 00:00:00