Low bone turnover levels predict increased risk of cancer.

abstract：:Profound bone loss at weight bearing sites is a primary effect of long-duration spaceflight. Moreover, a significant increase in estimated fracture risk remains even 1 year after returning to Earth; hence, it is important to define how quickly bone integrity can recover following prolonged disuse. This study character...

journal_title：Bone

authors： Shirazi-Fard Y,Kupke JS,Bloomfield SA,Hogan HA

更新日期：2013-01-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is now defined by the presence of exposed bone in the mouth, which fails to heal after appropriate intervention over a period of six or eight weeks. It is commonly precipitated by a tooth extraction in patients treated with zoledronate, pamidronate or a combination of these agents, for t...

journal_title：Bone

authors： Reid IR

更新日期：2009-01-01 00:00:00

abstract：:Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...

journal_title：Bone

authors： Nakano T,Kaibara K,Ishimoto T,Tabata Y,Umakoshi Y

更新日期：2012-10-01 00:00:00

abstract：:The aim of the present study was to assess age-related changes in the human spine by use of established static histomorphometry, and to determine how these static histomorphometric measures are interrelated in human cancellous bone tissue. The material comprised normal human lumbar vertebral bodies (L-2) from 12 women...

journal_title：Bone

authors： Thomsen JS,Ebbesen EN,Mosekilde L

更新日期：2000-07-01 00:00:00

abstract：:Identification of a reliable marker of skeletal precursor cells within calcified and soft tissues remains a major challenge for the field. To address this, we used a transgenic model in which osteoblasts can be eliminated by pharmacological treatment. Following osteoblast ablation a dramatic increase in a population o...

journal_title：Bone

authors： Kalajzic Z,Li H,Wang LP,Jiang X,Lamothe K,Adams DJ,Aguila HL,Rowe DW,Kalajzic I

更新日期：2008-09-01 00:00:00

abstract：:Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of plate...

journal_title：Bone

authors： Kandler B,Maitz P,Fischer MB,Watzek G,Gruber R

更新日期：2005-04-01 00:00:00

abstract：:This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...

journal_title：Bone

authors： Gibson JH,Harries M,Mitchell A,Godfrey R,Lunt M,Reeve J

更新日期：2000-06-01 00:00:00

abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...

journal_title：Bone

authors： Jonasson G,Sundh V,Ahlqwist M,Hakeberg M,Björkelund C,Lissner L

更新日期：2011-10-01 00:00:00

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00

abstract：:Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effe...

journal_title：Bone

authors： Liverani C,Mercatali L,Spadazzi C,La Manna F,De Vita A,Riva N,Calpona S,Ricci M,Bongiovanni A,Gunelli E,Zanoni M,Fabbri F,Zoli W,Amadori D,Ibrahim T

更新日期：2014-09-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：:The present work was designed to investigate the effects of oscillating fluid flow on gap junctional intercellular communication (GJIC) and the gap junction protein connexin (Cx) 43 in osteocyte-like MLOY-4 cells. Cells were exposed for 1 h to oscillating fluid flow at a shear stress of +/-10 dyn/cm(2) and a frequency...

journal_title：Bone

authors： Alford AI,Jacobs CR,Donahue HJ

更新日期：2003-07-01 00:00:00

abstract：:The process of bone turnover displays variations over 24 h, with C-terminal cross-linked telopeptide of type 1 collagen (CTX) and osteocalcin exhibiting a nadir in the afternoon and a peak in the night. In contrast, N-terminal propeptide of type 1 procollagen (P1NP) did not display an apparent 24-hour rhythm. Other em...

journal_title：Bone

authors： van der Spoel E,Oei N,Cachucho R,Roelfsema F,Berbée JFP,Blauw GJ,Pijl H,Appelman-Dijkstra NM,van Heemst D

更新日期：2019-03-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...

journal_title：Bone

authors： Borer KT,Fogleman K,Gross M,La New JM,Dengel D

更新日期：2007-10-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulated to regulate the o...

journal_title：Bone

authors： Wu J,Zhao J,Sun L,Pan Y,Wang H,Zhang WB

更新日期：2018-03-01 00:00:00

abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...

journal_title：Bone

authors： Yamaza T,Tsuji Y,Goto T,Kido MA,Nishijima K,Moroi R,Akamine A,Tanaka T

更新日期：2001-07-01 00:00:00

abstract：:Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...

journal_title：Bone

authors： Franceschetti P,Bondanelli M,Caruso G,Ambrosio MR,Lorusso V,Zatelli MC,Massari L,Degli Uberti EC

更新日期：2013-10-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...

journal_title：Bone

authors： Wang L,Shao YY,Ballock RT

更新日期：2005-09-01 00:00:00

abstract：:Previous work with cultured primary cells, from our group and from other laboratories, has shown that signals from extracellular matrix, transduced by integrins, play critical roles in regulating gene expression, tissue-specific differentiation, and survival of primary osteoblasts and fibroblasts. This summary will fo...

journal_title：Bone

authors： Damsky CH

更新日期：1999-07-01 00:00:00

abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

journal_title：Bone

authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

更新日期：2013-08-01 00:00:00

abstract：:We performed a comprehensive analysis of the relationships between histologic indices in the iliac crest (cancellous bone volume, trabecular structural indices, cortical width, and core width) and bone density in the spine, hip, and wrist in 81 patients with various metabolic bone diseases including osteoporosis, oste...

journal_title：Bone

authors： Cosman F,Schnitzer MB,McCann PD,Parisien MV,Dempster DW,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual a...

journal_title：Bone

authors： Pauchard Y,Liphardt AM,Macdonald HM,Hanley DA,Boyd SK

更新日期：2012-06-01 00:00:00

abstract：:Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...

journal_title：Bone

authors： Lu X,Ito Y,Atsawasuwan P,Dangaria S,Yan X,Wu T,Evans CA,Luan X

更新日期：2013-05-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...

journal_title：Bone

authors： Muschitz C,Kocijan R,Haschka J,Pahr D,Kaider A,Pietschmann P,Hans D,Muschitz GK,Fahrleitner-Pammer A,Resch H

更新日期：2015-10-01 00:00:00

abstract：:Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption...

journal_title：Bone

authors： Cho K,Demissie S,Dupuis J,Cupples LA,Kathiresan S,Beck TJ,Karasik D,Kiel DP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular micr...

journal_title：Bone

authors： Vom Scheidt A,Grisolia Seifert EF,Pokrant C,Püschel K,Amling M,Busse B,Milovanovic P

更新日期：2019-05-01 00:00:00

abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

journal_title：Bone

authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

更新日期：1997-10-01 00:00:00

abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...

journal_title：Bone

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2019-06-01 00:00:00