Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.


CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol administration in physiologic doses increases BMD in adolescents and adults with FHA. However, the impact of estrogen replacement on MAT in relation to changes in BMD has not been studied in adolescents and young adults. We hypothesized that physiologic estrogen replacement would lead to decreases in MAT, associated with increases in BMD. METHODS AND MATERIALS:We studied 15 adolescent and young adult females with FHA (14-25 years). All participants received a17β- estradiol transdermal patch at a dose of 0.1 mg/day (applied twice weekly) for 12 months. Participants also received cyclic progestin for 10-12 days each month. We quantified MAT (lipid/water ratio) of the fourth lumbar (L4) vertebral body and femoral diaphysis by single proton (1H)-magnetic resonance spectroscopy, and compartmental volumetric BMD of the distal radius and tibia using high-resolution peripheral quantitative computed tomography. RESULTS:Transdermal estradiol therapy over 12 months resulted in a decrease in MAT at the lumbar (L4) vertebra from 0.92 ± 0.55 at baseline to 0.63 ± 0.29 at 12-months (p = 0.008), and an increase in radial and tibial cortical vBMD (p = 0.006, p = 0.0003). Changes in L4 MAT trended to be inversely associated with changes in radial cortical vBMD (rho = -0.47, p = 0.08). CONCLUSION:We show that in adolescent and young adult girls with FHA, MAT decreases following transdermal estrogen therapy and these changes are associated with increased cortical vBMD.






Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M




Has Abstract


2021-01-06 00:00:00














  • Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis).

    abstract::Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...


    pub_type: 杂志文章


    authors: Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

    更新日期:2001-08-01 00:00:00

  • The short- and long-term effects of methotrexate on the rat skeleton.

    abstract::Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has adverse short-term effects on bone. There are no studies that demonstrate the long-term response of bone to MTX. The purpose of this study was to determine the short- and long-term effects of MTX on bone volume, turnove...


    pub_type: 杂志文章


    authors: Wheeler DL,Vander Griend RA,Wronski TJ,Miller GJ,Keith EE,Graves JE

    更新日期:1995-02-01 00:00:00

  • Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing.

    abstract::Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...


    pub_type: 杂志文章


    authors: Lu Y,Alharbi M,Zhang C,O'Connor JP,Graves DT

    更新日期:2019-06-01 00:00:00

  • Design and optimization of the oriented groove on the hip implant surface to promote bone microstructure integrity.

    abstract::We proposed a novel surface modification for an artificial hip joint stem from the viewpoint of maintenance and establishment of appropriate bone function and microstructure, represented by the preferred alignment of biological apatite (BAp) and collagen (Col). Oriented grooves were introduced into the proximal medial...


    pub_type: 杂志文章


    authors: Noyama Y,Nakano T,Ishimoto T,Sakai T,Yoshikawa H

    更新日期:2013-02-01 00:00:00

  • Positive association between the course of vitamin D intake and bone mineral density at 36 years in men.

    abstract:INTRODUCTION:Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of...


    pub_type: 杂志文章


    authors: van Dijk CE,de Boer MR,Koppes LL,Roos JC,Lips P,Twisk JW

    更新日期:2009-03-01 00:00:00

  • Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation.

    abstract::Bone homeostasis is regulated by a balance of bone formation and bone resorption; dysregulation of bone homeostasis may cause bone-related diseases (e.g., osteoporosis, osteopetrosis, bone fracture). Members of the nuclear factor of activated T cells (NFAT) family of transcription factors play crucial roles in the reg...


    pub_type: 杂志文章


    authors: Kim HM,He L,Lee S,Park C,Kim DH,Han HJ,Han J,Hwang J,Cha-Molstad H,Lee KH,Ko SK,Jang JH,Ryoo IJ,Blenis J,Lee HG,Ahn JS,Kwon YT,Soung NK,Kim BY

    更新日期:2020-02-01 00:00:00

  • Synergistic effect of Wnt modulatory small molecules and an osteoinductive ceramic on C2C12 cell osteogenic differentiation.

    abstract::Although osteoinductive ceramics can induce osteoblast differentiation in vitro and bone regeneration in vivo, their effects rely solely on the limited number of endogenous stem cells. More recently, ceramic carriers seeded with culture-expanded stem cells have been reported as implants capable of in vivo bone formati...


    pub_type: 杂志文章


    authors: Chen S,Ryan DA,Dwyer MA,Cashman JR

    更新日期:2014-10-01 00:00:00

  • Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts.

    abstract::We have previously shown that the therapeutic range of ultrasound heals osteoradionecrotic bone and induces bone formation in vitro. It is well established that nitric oxide (NO) and prostaglandins are crucial early mediators in mechanically induced bone formation. The therapeutic range of ultrasound may act in the sa...


    pub_type: 杂志文章


    authors: Reher P,Harris M,Whiteman M,Hai HK,Meghji S

    更新日期:2002-07-01 00:00:00

  • Bone metastasis in prostate cancer: Recurring mitochondrial DNA mutation reveals selective pressure exerted by the bone microenvironment.

    abstract:BACKGROUND:Cancer progression and metastasis occur such that cells with acquired mutations enhancing growth and survival (or inhibiting cell death) increase in number, a concept that has been recognized as analogous to Darwinian evolution of species since Peter C. Nowell's description in 1976. Selective forces include ...


    pub_type: 杂志文章


    authors: Arnold RS,Fedewa SA,Goodman M,Osunkoya AO,Kissick HT,Morrissey C,True LD,Petros JA

    更新日期:2015-09-01 00:00:00

  • miRNAs in osteoclast biology.

    abstract::MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...


    pub_type: 杂志文章


    authors: Weivoda MM,Lee SK,Monroe DG

    更新日期:2021-02-01 00:00:00

  • Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur.

    abstract::Osteopetrotic bone shows dissociation between bone mineral density (BMD) and bone strength. In this study, volumetric BMD; preferential orientation of the extracellular matrix (ECM), which is composed of collagen fibers and apatite crystals as bone material quality; and mechanical properties of the src-/- osteopetroti...


    pub_type: 杂志文章


    authors: Ishimoto T,Sato B,Lee JW,Nakano T

    更新日期:2017-10-01 00:00:00

  • Evaluation of the role of second messenger systems in tumor necrosis factor-stimulated resorption of fetal rat limb bones.

    abstract::Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...


    pub_type: 杂志文章


    authors: Shankar G,Stern PH

    更新日期:1993-11-01 00:00:00

  • Effects of minodronate on cortical bone response to mechanical loading in rats.

    abstract::The effects of BPs on bone formation during mechanical loading are still unknown. In this study, we evaluated the effect of minodronate on the cortical bone response to mechanical loading applied using a 4-point bending device. We used six-month old female Wistar rats and randomized into five groups (N=10/group): Vehi...


    pub_type: 杂志文章


    authors: Nagira K,Hagino H,Kameyama Y,Teshima R

    更新日期:2013-03-01 00:00:00

  • Local communication on and within bone controls bone remodeling.

    abstract::Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occur in a tightly regulated sequence of events, where the amount of formed bone equals the amount of resorbed bone, thereby re...


    pub_type: 杂志文章,评审


    authors: Henriksen K,Neutzsky-Wulff AV,Bonewald LF,Karsdal MA

    更新日期:2009-06-01 00:00:00

  • Efficacy of anti-IL-23 monotherapy versus combination therapy with anti-IL-17 in estrogen deficiency induced bone loss conditions.

    abstract::Recent studies have identified that Interleukin (IL)-23/IL-17 axis plays crucial role in pathogenesis of inflammation and bone destruction. IL-23 is thought to promote joint destruction in arthritis by stimulating Th17 cells. IL-23 directly mediates bone loss by inducing osteoclastogenesis and receptor activator of ka...


    pub_type: 杂志文章


    authors: Shukla P,Mansoori MN,Singh D

    更新日期:2018-05-01 00:00:00

  • Fracture incidence after denosumab discontinuation: Real-world data from a large healthcare provider.

    abstract:BACKGROUND:Vertebral fractures (VF) upon Denosumab (DMAB) discontinuation were first described as a distinct phenomenon in 2015, yet the magnitude of this event remains undetermined. OBJECTIVES:To estimate fracture risk after DMAB discontinuation, in a real-world setting. METHODS:The computerized database of a 2.3-mi...


    pub_type: 杂志文章


    authors: Tripto-Shkolnik L,Fund N,Rouach V,Chodick G,Shalev V,Goldshtein I

    更新日期:2020-01-01 00:00:00

  • Intensity-related differences in collagen post-translational modification in MC3T3-E1 osteoblasts after exposure to low- and high-intensity pulsed ultrasound.

    abstract::Low-intensity pulsed ultrasound (LIPUS) has distinct effects on biologic mineralization at intensities of <100 mW/cm2. Intensity-dependent differences in the pattern of accelerated mineralization may be due to different alterations in regulation of collagenous matrix formation. However, little is known about the influ...


    pub_type: 杂志文章


    authors: Saito M,Soshi S,Tanaka T,Fujii K

    更新日期:2004-09-01 00:00:00

  • Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) are at high risk for fracture. The ability of bone mineral density (BMD) to predict fractures in CKD patients has been inconsistent. Other measures such as trabecular bone score (TBS) and impact microindentation (IMI) may be more useful in this group. This study aim...


    pub_type: 杂志文章


    authors: Holloway-Kew KL,Rufus-Membere P,Anderson KB,Betson A,Gaston J,Kotowicz MA,Diez-Perez A,Hyde NK,Pasco JA

    更新日期:2020-04-01 00:00:00

  • Secular trends in distal humeral fractures of elderly women: nationwide statistics in Finland between 1970 and 2007.

    abstract::In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...


    pub_type: 杂志文章


    authors: Palvanen M,Kannus P,Niemi S,Parkkari J

    更新日期:2010-05-01 00:00:00

  • Ultrashort echo time magnetic resonance imaging (UTE-MRI) of cortical bone correlates well with histomorphometric assessment of bone microstructure.

    abstract::Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores small...


    pub_type: 杂志文章


    authors: Jerban S,Ma Y,Wong JH,Nazaran A,Searleman A,Wan L,Williams J,Du J,Chang EY

    更新日期:2019-06-01 00:00:00

  • Perinatal hypophosphatasia caused by uniparental isodisomy.

    abstract::Hypophosphatasia (HPP) is an inherited disorder characterized by defective bone mineralization caused by mutations in the alkaline phosphatase gene (ALPL). Clinically, the disease spans a great continuum of disease severity and six forms can be distinguished according to the age of onset. The most severe is the autoso...


    pub_type: 杂志文章


    authors: Watanabe A,Satoh S,Fujita A,Naing BT,Orimo H,Shimada T

    更新日期:2014-03-01 00:00:00

  • Relationships between marrow fat and bone turnover in ovariectomized and intact rats.

    abstract::It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...


    pub_type: 杂志文章


    authors: Martin RB,Zissimos SL

    更新日期:1991-01-01 00:00:00

  • Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP).

    abstract:BACKGROUND:Episodic flare-ups of fibrodysplasia ossificans progressiva (FOP) are characterized clinically by severe, often posttraumatic, connective tissue swelling and intramuscular edema, followed histologically by an intense and highly angiogenic fibroproliferative reaction. This early inflammatory and angiogenic fi...


    pub_type: 杂志文章


    authors: Brennan TA,Lindborg CM,Bergbauer CR,Wang H,Kaplan FS,Pignolo RJ

    更新日期:2018-04-01 00:00:00

  • Rapidly growing Brtl/+ mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment.

    abstract::Osteogenesis imperfecta (OI) is a heritable collagen-related bone dysplasia, characterized by brittle bones with increased fracture risk that presents most severely in children. Anti-resorptive bisphosphonates are frequently used to treat pediatric OI and controlled clinical trials have shown that bisphosphonate thera...


    pub_type: 杂志文章


    authors: Sinder BP,Salemi JD,Ominsky MS,Caird MS,Marini JC,Kozloff KM

    更新日期:2015-02-01 00:00:00

  • Clinical burden and incremental cost of fractures in postmenopausal women in the United Kingdom.

    abstract::This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...


    pub_type: 杂志文章


    authors: Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

    更新日期:2012-09-01 00:00:00

  • Common herbs, essential oils, and monoterpenes potently modulate bone metabolism.

    abstract::During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...


    pub_type: 杂志文章


    authors: Mühlbauer RC,Lozano A,Palacio S,Reinli A,Felix R

    更新日期:2003-04-01 00:00:00

  • Bone mass and endocrine adaptations to training in spinal cord injured individuals.

    abstract::To investigate whether exercise training can produce increases in bone mass in spinal cord-injured (SCI) individuals with established disuse osteopenia, nine subjects (age 28.2 years, time since injury 6.0 years, level of injury C5-T7) were recruited for a 9-month training program using functional electrical stimulati...


    pub_type: 临床试验,杂志文章


    authors: Bloomfield SA,Mysiw WJ,Jackson RD

    更新日期:1996-07-01 00:00:00

  • A reference standard for the description of osteoporosis.

    abstract::In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...


    pub_type: 杂志文章,评审


    authors: Kanis JA,McCloskey EV,Johansson H,Oden A,Melton LJ 3rd,Khaltaev N

    更新日期:2008-03-01 00:00:00

  • Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

    abstract::Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesize...


    pub_type: 杂志文章


    authors: Perrier A,Dumas V,Linossier MT,Fournier C,Jurdic P,Rattner A,Vico L,Guignandon A

    更新日期:2010-07-01 00:00:00

  • Focal changes in blood supply during normal epiphyseal growth are central in the pathogenesis of osteochondrosis in pigs.

    abstract::Cartilage canals are temporary vessel-containing structures within the growth cartilage. The canals gradually regress with age in a process designated chondrification, where the content of the canals is replaced by cartilage. The process of chondrification is considered physiological; however, premature regression has...


    pub_type: 杂志文章


    authors: Ytrehus B,Ekman S,Carlson CS,Teige J,Reinholt FP

    更新日期:2004-12-01 00:00:00