Abstract:
:Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spine in postmenopausal women and to determine if effects are modified by variations in protocol design. We undertook a systematic review and meta-analysis of randomised (RCTs) and non-randomised controlled trials. Electronic bibliographic databases, key journals and reference lists of reviews and articles were searched to identify studies for inclusion. Randomised and non-randomised controlled trials assessing the effects of walking on lumbar spine, femoral neck and total hip BMD, measured by radiographic techniques, among sedentary postmenopausal women were eligible for inclusion. Two independent reviewers assessed studies for eligibility. Reported absolute BMD outcomes were combined in the analysis. Weighted mean differences (WMD) were calculated using a fixed and random-effects models. Heterogeneity among trials was examined using the Q statistic and I2 methods. Potential publication bias was assessed through funnel plot inspection. Assessment of trial quality was also performed using the widely used instrument devised by Jadad et al. [Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Cont Clin Trials 1996; 17:1-12]. Eight trials were eligible for inclusion. Treatment duration ranged from 6 to 24 months. All eight trials reported BMD data at the lumbar spine following walking interventions among postmenopausal women. Meta-analysis showed no significant change in BMD at this site [WMD (fixed-effect) 0.007 g/cm2 95% CI (-0.001 to 0.016); P=0.09)]. BMD data at the femoral neck were available from five trials among postmenopausal women. Results were inconsistent (I2=51.4%) in showing a positive effect of walking on BMD at this site [WMD (random-effects) 0.014 g/cm2 95% CI (0.000 to 0.028); P=0.05). Insufficient data were available for meta-analysis of the total hip site. Funnel plots showed some asymmetry for negative lumbar spine BMD outcomes. Trial quality scores ranged from 0 to 3 from the Jadad scale of 0 to 5. We conclude that regular walking has no significant effect on preservation of BMD at the spine in postmenopausal women, whilst significant positive effects at femoral neck are evident. However, diverse methodological and reporting discrepancies are apparent in the published trials on which these conclusions are based. Other forms of exercise that provide greater targeted skeletal loading may be required to preserve bone mineral density in this population.
journal_name
Bonejournal_title
Boneauthors
Martyn-St James M,Carroll Sdoi
10.1016/j.bone.2008.05.012subject
Has Abstractpub_date
2008-09-01 00:00:00pages
521-31issue
3eissn
8756-3282issn
1873-2763pii
S8756-3282(08)00276-7journal_volume
43pub_type
杂志文章,meta分析相关文献
BONE文献大全abstract::This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.010
更新日期:2010-03-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.05.024
更新日期:2010-08-01 00:00:00
abstract::Twenty patients with mild Paget's disease of bone were given either 20 (10 patients) or 40 mg alendronate daily for 6 months. The 20-mg dose was well tolerated, but in 3 patients on 40 mg/d alendronate, the treatment was withdrawn after 3-5 months because of gastric and oesophageal disturbances. Urinary hydroxyproline...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(94)90818-4
更新日期:1994-07-01 00:00:00
abstract::Tight interactions among different cell types contributing to bone formation are of key importance in the maintenance of bone homeostasis. Based on the high similarity in responses to (anti)osteogenic signals between zebrafish scales and mammalian bone, we developed and validated a model to screen large numbers of com...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.01.006
更新日期:2015-05-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115513
更新日期:2020-09-01 00:00:00
abstract::This review begins with an introduction to the malignant bone tumor, osteosarcoma [OS] and then moves to a discussion of the commonly used vectors for gene transfer. We first briefly highlight non-viral vectors including polymeric and liposomal delivery systems but concentrate predominantly on the 5 leading viral vect...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2006.10.017
更新日期:2007-04-01 00:00:00
abstract::PEBP2alphaA/AML3/CBFA1 is one of the transcription regulators that belong to the PEBP2/AML family. The knockout mice, where the gene encoding PEBP2alphaA/AML3/CBFA1 was inactivated, showed no osteogenesis, indicating the critical role of this transcription factor in osteoblastic differentiation (Komori, Y. et al. Cell...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00267-6
更新日期:1998-02-01 00:00:00
abstract::The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90400-4
更新日期:1985-01-01 00:00:00
abstract::Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00504-8
更新日期:1996-03-01 00:00:00
abstract::This in vivo study investigated the influence of two calcium phosphate particle sizes (40-80 microm and 200-500 microm) on the cellular degradation activity associated with the bone substitution process of two injectable bone substitutes (IBS). The tested biomaterials were obtained by associating a biphasic calcium ph...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00137-4
更新日期:1999-08-01 00:00:00
abstract::Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.07.003
更新日期:2016-10-01 00:00:00
abstract::Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115665
更新日期:2021-02-01 00:00:00
abstract::We studied the differences in the patterns of trabecular bone loss induced by various kinds of experimental osteopenia in the rat, including ovariectomy, sciatic neurotomy (partial paralysis of hind-limb), hemicordotomy (complete paralysis of hind-limb), and their combinations. The cut surface of the metaphysis of pro...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90041-g
更新日期:1991-01-01 00:00:00
abstract::Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00362-6
更新日期:1997-03-01 00:00:00
abstract::Osteoimmunological interactions are central to maintaining bone homeostasis and are key mechanisms in bone pathology. Macrophages are highly adaptable cells with pleiotropic actions. They have important roles in development, homeostasis and both innate and adaptive immunity. Macrophages can have broad ranging effects ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.08.128
更新日期:2008-12-01 00:00:00
abstract::Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90027-0
更新日期:1988-01-01 00:00:00
abstract::Mitochondria play a key role in cell physiology including cell differentiation and proliferation. We investigated the changes of mitochondrial biogenesis during Wnt-induced osteoblastic differentiation of murine mesenchymal C3H10T1/2 cells. Scanning electron microscopy demonstrated that activation of Wnt signaling by ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.04.593
更新日期:2010-07-01 00:00:00
abstract::Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(03)00112-1
更新日期:2003-09-01 00:00:00
abstract:INTRODUCTION:In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115649
更新日期:2021-02-01 00:00:00
abstract::Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenet...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2019.115114
更新日期:2020-02-01 00:00:00
abstract::Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlled by the cytokine R...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.113
更新日期:2012-11-01 00:00:00
abstract::Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00829-3
更新日期:2002-08-01 00:00:00
abstract::Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::Although osteoinductive ceramics can induce osteoblast differentiation in vitro and bone regeneration in vivo, their effects rely solely on the limited number of endogenous stem cells. More recently, ceramic carriers seeded with culture-expanded stem cells have been reported as implants capable of in vivo bone formati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.032
更新日期:2014-10-01 00:00:00
abstract:CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2021.115841
更新日期:2021-01-06 00:00:00
abstract::Despite the potential biological importance of sympathetic activity in human bone metabolism, its effects on bone microarchitecture, a key determinant of bone quality, has not been thoroughly studied. In the present study, we investigated the lumbar spine trabecular bone score (TBS) as an indicator of skeletal deterio...
journal_title:Bone
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.bone.2018.06.023
更新日期:2018-11-01 00:00:00
abstract::Achondroplasia (ACH), the most common form of human dwarfism is caused by a mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene, resulting in constitutive activation of the receptor. Typical radiological features include shortening of the tubular bones and macrocephaly, due to disruption of endochondral o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.020
更新日期:2010-11-01 00:00:00
abstract::Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.08.004
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.12.005
更新日期:2008-04-01 00:00:00
abstract::Bone strength in adulthood is known to be affected by health at birth and early childhood. Habitual bone loading is a primary determinant of bone strength in later childhood and adulthood. However, the effects of physical activity in early childhood (e.g. crawling, standing and walking) on bone strength are unknown. F...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.08.003
更新日期:2014-11-01 00:00:00