Abstract：
:Osteoimmunological interactions are central to maintaining bone homeostasis and are key mechanisms in bone pathology. Macrophages are highly adaptable cells with pleiotropic actions. They have important roles in development, homeostasis and both innate and adaptive immunity. Macrophages can have broad ranging effects on bone, particularly in pathologic situations, but they are most commonly considered for their in vitro potential as an osteoclast precursor. We have recently shown that, like most tissues, the endosteum and periosteum contain a population of resident tissue macrophages (OsteoMacs) that impact on the bone formation process and are likely to play important roles in the bone niche. This review discusses the wider impact of macrophages in bone homeostasis and disease and proposes novel roles for OsteoMacs in bone modelling and remodelling.
journal_name
Bonejournal_title
Boneauthors
Pettit AR,Chang MK,Hume DA,Raggatt LJdoi
10.1016/j.bone.2008.08.128subject
Has Abstractpub_date
2008-12-01 00:00:00pages
976-82issue
6eissn
8756-3282issn
1873-2763pii
S8756-3282(08)00759-Xjournal_volume
43pub_type
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