Bone mass and comparative rates of bone resorption and formation of fibular autografts: comparison of vascular and nonvascular grafts in dogs.

abstract：:Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...

journal_title：Bone

authors： Heaney RP

更新日期：1992-01-01 00:00:00

abstract：:It is well established that short-term clearance of an intravenous calcium load in vivo reflects bone uptake. Using results from isotope-dilution experiments with 42Ca, a 3-h test has been developed to measure a quantity, gamma, related to bone accretion. This test is proposed as a useful, clinically applicable measur...

journal_title：Bone

authors： Goans RE,Abrams SA,Vieira NE,Marini JC,Perez MD,Yergey AL

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...

journal_title：Bone

authors： Kemmler W,Kohl M,Fröhlich M,Schoene D,von Stengel S

更新日期：2021-01-01 00:00:00

abstract：:Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has been reported that older age is associated with higher serum levels of the inflammatory cytokine IL-18. In the present study, we investigated the long-term role of serum IL-18 in cartilage loss in vivo using a new strain o...

journal_title：Bone

authors： Inoue H,Hiraoka K,Hoshino T,Okamoto M,Iwanaga T,Zenmyo M,Shoda T,Aizawa H,Nagata K

更新日期：2008-06-01 00:00:00

abstract：:We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...

journal_title：Bone

authors： Specker B,Binkley T

更新日期：2004-12-01 00:00:00

abstract：:Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...

journal_title：Bone

authors： Basle MF,Mazaud P,Malkani K,Chretien MF,Moreau MF,Rebel A

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Spinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI. METHOD...

journal_title：Bone

authors： Edwards WB,Schnitzer TJ,Troy KL

更新日期：2014-03-01 00:00:00

abstract：:Achondroplasia (ACH) and thanatophoric dysplasia (TD) are human skeletal disorders of increasing severity accounted for by mutations in the fibroblast growth factor receptor 3 (FGFR3). Attempts to elucidate the molecular signaling pathways leading to these phenotypes through mouse model engineering have provided relev...

journal_title：Bone

authors： Legeai-Mallet L,Benoist-Lasselin C,Munnich A,Bonaventure J

更新日期：2004-01-01 00:00:00

abstract：:This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...

journal_title：Bone

authors： Miyauchi A,Matsumoto T,Sugimoto T,Tsujimoto M,Warner MR,Nakamura T

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:Osteoporosis results in loss of bone mass and microarchitectural deterioration. Dental radiographs potentially offer a means of screening for osteoporosis as they are commonly made on adults. Spatial frequency analyses are well suited to detect subtle changes in image patterns. We hypothesize that individual...

journal_title：Bone

authors： Faber TD,Yoon DC,Service SK,White SC

更新日期：2004-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...

journal_title：Bone

authors： Post S,Abdallah BM,Bentzon JF,Kassem M

更新日期：2008-07-01 00:00:00

abstract：:Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...

journal_title：Bone

authors： van Beek E,Oostendorp-van de Ruit M,van der Wee-Pals L,Bloys H,van de Bent C,Papapoulos S,Löwik C

更新日期：1995-07-01 00:00:00

abstract：:A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...

journal_title：Bone

authors： Ortoft G,Oxlund H

更新日期：1996-06-01 00:00:00

abstract：:Bone turnover occurs at discreet sites in the remodeling skeleton. The focal nature of this process indicates that local cues may facilitate the activation of bone cells by systemic factors. Nucleotides such as adenosine triphosphate (ATP) are locally released, short-lived, yet potent extracellular signaling molecules...

journal_title：Bone

authors： Bowler WB,Buckley KA,Gartland A,Hipskind RA,Bilbe G,Gallagher JA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephr...

journal_title：Bone

authors： DeLacey S,Liu Z,Broyles A,El-Azab SA,Guandique CF,James BC,Imel EA

更新日期：2019-10-01 00:00:00

abstract：:Osteoclastic bone degradation depends on the activity of several proteolytic enzymes, in particular to those belonging to the classes of cysteine proteinases and matrix metalloproteinases (MMPs). Yet, several findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and...

journal_title：Bone

authors： Everts V,Daci E,Tigchelaar-Gutter W,Hoeben KA,Torrekens S,Carmeliet G,Beertsen W

更新日期：2008-11-01 00:00:00

abstract：:In this study we report on histological and ultrastructural investigations of the mandibular cortical bone in a case of autosomal dominant osteopetrosis type II complicated by mandibular osteomyelitis. Histologically, there was a marked increase in the number and size of osteoclasts on the inner bone surface. An undec...

journal_title：Bone

authors： Semba I,Ishigami T,Sugihara K,Kitano M

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...

journal_title：Bone

authors： Frost M,Tencerova M,Andreasen CM,Andersen TL,Ejersted C,Svaneby D,Qui W,Kassem M,Zarei A,McAlister WH,Veis DJ,Whyte MP,Frederiksen AL

更新日期：2019-04-01 00:00:00

abstract：:The traditional view of osteoporotic fractures is that they result from a reduction in bone mass combined with alterations in the micro-architecture. Apart from the effects of bone remodeling, the material properties of the remaining bone are thought to be unaffected. To test this, we compared the degree of matrix min...

journal_title：Bone

authors： Loveridge N,Power J,Reeve J,Boyde A

更新日期：2004-10-01 00:00:00

abstract：:In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...

journal_title：Bone

authors： Bollerslev J,Marks SC Jr,Pockwinse S,Kassem M,Brixen K,Steiniche T,Mosekilde L

更新日期：1993-11-01 00:00:00

abstract：:Previous work with cultured primary cells, from our group and from other laboratories, has shown that signals from extracellular matrix, transduced by integrins, play critical roles in regulating gene expression, tissue-specific differentiation, and survival of primary osteoblasts and fibroblasts. This summary will fo...

journal_title：Bone

authors： Damsky CH

更新日期：1999-07-01 00:00:00

abstract：:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...

journal_title：Bone

authors： Sugimoto M,Futaki N,Harada M,Kaku S

更新日期：2013-01-01 00:00:00

abstract：:Although low bone mineral density (BMD) is strongly associated with increased fracture risk, up to 50% of those who suffer fractures are not detected as high-risk patients by BMD testing. Thus, new approaches may improve identification of those at increased risk for fracture by in vivo assessment of altered bone tissu...

journal_title：Bone

authors： Karim L,Van Vliet M,Bouxsein ML

更新日期：2018-01-01 00:00:00

abstract：:Bone resorption is a multistep process including osteoclast attachment, cytoskeletal reorganization, formation of four distinct plasma membrane domains, and matrix demineralization and degradation followed by cell detachment. The present study describes the intracellular mechanisms by which overexpression of cathepsin...

journal_title：Bone

authors： Morko J,Kiviranta R,Mulari MT,Ivaska KK,Väänänen HK,Vuorio E,Laitala-Leinonen T

更新日期：2009-04-01 00:00:00

abstract：:Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...

journal_title：Bone

authors： Wenzel TE,Schaffler MB,Fyhrie DP

更新日期：1996-08-01 00:00:00

abstract：:While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...

journal_title：Bone

authors： Omata Y,Frech M,Lucas S,Primbs T,Knipfer L,Wirtz S,Kadono Y,Saito T,Tanaka S,Sarter K,Schett G,Zaiss MM

更新日期：2020-07-01 00:00:00

abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...

journal_title：Bone

authors： Elli FM,Barbieri AM,Bordogna P,Ferrari P,Bufo R,Ferrante E,Giardino E,Beck-Peccoz P,Spada A,Mantovani G

更新日期：2013-10-01 00:00:00

abstract：:The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By...

journal_title：Bone

authors： Macias BR,Aspenberg P,Agholme F

更新日期：2013-04-01 00:00:00

abstract：:Osteopontin (OPN) gene expression and alkaline phosphatase activity were evaluated in the epiphyseal growth plates of normal chickens and in diet-induced tibial dyschdroplasia (TD)-afflicted chickens. In the normal growth plate, OPN gene was expressed by a) cells of the subperichondrial zone surrounding the articular ...

journal_title：Bone

authors： Knopov V,Leach RM,Barak-Shalom T,Hurwitz S,Pines M

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00