Fourier and wavelet analyses of dental radiographs detect trabecular changes in osteoporosis.


OBJECTIVES:Osteoporosis results in loss of bone mass and microarchitectural deterioration. Dental radiographs potentially offer a means of screening for osteoporosis as they are commonly made on adults. Spatial frequency analyses are well suited to detect subtle changes in image patterns. We hypothesize that individuals with osteoporosis exhibit an altered radiographic trabecular pattern that can be detected by spatial frequency and strut analysis. STUDY DESIGN:Maxillary and mandibular periapical radiographs of 26 women with osteoporosis and 23 controls were examined using one-dimensional discrete Fourier and wavelet analyses in both jaws to measure the spatial frequency distributions of trabecular structures. A strut analysis was also performed. RESULTS:Individuals with osteoporosis revealed an altered trabecular pattern compared to controls. Using Fourier and strut variables allows classification of subjects with 92% sensitivity, 96% specificity, and a 22% cross-validation error rate. Wavelet analysis was also useful but did not perform better than Fourier analysis for subject classification. CONCLUSIONS:Spatial frequency analysis of digitized dental radiographs, especially Fourier analysis, and strut analysis provide value for identifying individuals with osteoporosis.






Faber TD,Yoon DC,Service SK,White SC




Has Abstract


2004-08-01 00:00:00
















  • Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients.

    abstract::Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) within the gene TNSALP that encodes the "tissue-nonspecific" isoenzyme of alkaline phosphatase (TNSALP). In HPP, inorganic pyrophosphate, an inhibitor of mineralization and substrate for TNSALP, accumulates extracellularly often leading to rickets or ost...


    pub_type: 杂志文章


    authors: Whyte MP,Zhang F,Wenkert D,McAlister WH,Mack KE,Benigno MC,Coburn SP,Wagy S,Griffin DM,Ericson KL,Mumm S

    更新日期:2015-06-01 00:00:00

  • Identification of rat osteoclasts in bone smears with quantification of acid phosphatase activity in vitamin D deficiency.

    abstract::Vitamin D deficiency may depress bone formation but its effect on bone resorption is not well defined. As an index of bone resorption, the activity of acid phosphatase, a lysosomal enzyme found in osteoclasts, was quantitated in situ from a bone tissue smear preparation. Activity of the enzyme, measured by integrative...


    pub_type: 杂志文章


    authors: Silverton SF,Kaye M

    更新日期:1987-01-01 00:00:00

  • Effects of calcitonin on animal and in vitro models of skeletal metabolism.

    abstract::During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...


    pub_type: 杂志文章,评审


    authors: Wallach S,Rousseau G,Martin L,Azria M

    更新日期:1999-11-01 00:00:00

  • Material properties of mandibular cortical bone in the American alligator, Alligator mississippiensis.

    abstract::This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...


    pub_type: 杂志文章


    authors: Zapata U,Metzger K,Wang Q,Elsey RM,Ross CF,Dechow PC

    更新日期:2010-03-01 00:00:00

  • Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

    abstract::Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...


    pub_type: 杂志文章


    authors: McGee-Lawrence ME,Carpio LR,Bradley EW,Dudakovic A,Lian JB,van Wijnen AJ,Kakar S,Hsu W,Westendorf JJ

    更新日期:2014-09-01 00:00:00

  • Reference intervals of biochemical bone turnover markers for Saudi Arabian women: a cross-sectional study.

    abstract::Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...


    pub_type: 杂志文章


    authors: Ardawi MS,Maimani AA,Bahksh TA,Rouzi AA,Qari MH,Raddadi RM

    更新日期:2010-10-01 00:00:00

  • Relationships among ultrasonic and mechanical properties of cancellous bone in human calcaneus in vitro.

    abstract::Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical propertie...


    pub_type: 杂志文章


    authors: Wear KA,Nagaraja S,Dreher ML,Sadoughi S,Zhu S,Keaveny TM

    更新日期:2017-10-01 00:00:00

  • Histomorphometric changes in the trabecular structure of a selected stress region in the femur in patients with osteoarthritis and fracture of the femoral neck.

    abstract::Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in patients with osteoarthritis and fracture of the femoral neck are described. Femoral heads were obtained from patients who had surgery for the treatment of femoral neck fracture or total hip replacement for...


    pub_type: 杂志文章


    authors: Fazzalari NL,Darracott J,Vernon-Roberts B

    更新日期:1985-01-01 00:00:00

  • c-fos antisense DNA inhibits proliferation of osteoclast progenitors in osteoclast development but not macrophage differentiation in vitro.

    abstract::We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using this coculture system, we examined the effects of c-fos antisens...


    pub_type: 杂志文章


    authors: Udagawa N,Chan J,Wada S,Findlay DM,Hamilton JA,Martin TJ

    更新日期:1996-06-01 00:00:00

  • Moderate-intensity 4mT static magnetic fields prevent bone architectural deterioration and strength reduction by stimulating bone formation in streptozotocin-treated diabetic rats.

    abstract::Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and...


    pub_type: 杂志文章


    authors: Zhang H,Gan L,Zhu X,Wang J,Han L,Cheng P,Jing D,Zhang X,Shan Q

    更新日期:2018-02-01 00:00:00

  • Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

    abstract::Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...


    pub_type: 杂志文章


    authors: Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

    更新日期:2015-10-01 00:00:00

  • Hip fractures: incidence, risk factors, energy absorption, and prevention.

    abstract::The present review summarizes the pathogenic mechanisms leading to hip fracture based on epidemiological, experimental, and controlled clinical studies. The estimated lifetime risk of hip fracture is about 14% in postmenopausal women and 6% in men. The incidence of hip fractures increases exponentially with aging, but...


    pub_type: 杂志文章,评审


    authors: Lauritzen JB

    更新日期:1996-01-01 00:00:00

  • Intravenous olpadronate restores ovariectomy-affected bone strength. A mechanical, densitometric and tomographic (pQCT) study.

    abstract::Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect wa...


    pub_type: 杂志文章


    authors: Cointry GR,Mondelo N,Zanchetta JR,Montuori E,Ferretti JL

    更新日期:1995-10-01 00:00:00

  • Expression of bone microsomal casein kinase II, bone sialoprotein, and osteopontin during the repair of calvarial defects.

    abstract::The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...


    pub_type: 杂志文章


    authors: Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

    更新日期:1998-06-01 00:00:00

  • Osteocyte lacunar properties and cortical microstructure in human iliac crest as a function of age and sex.

    abstract::Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...


    pub_type: 杂志文章


    authors: Bach-Gansmo FL,Brüel A,Jensen MV,Ebbesen EN,Birkedal H,Thomsen JS

    更新日期:2016-10-01 00:00:00

  • MicroRNA-365 functions as a mechanosensitive microRNA to inhibit end plate chondrocyte degeneration by targeting histone deacetylase 4.

    abstract::End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...


    pub_type: 杂志文章


    authors: Zheng Q,Li XX,Xiao L,Shao S,Jiang H,Zhang XL,Sun LY,Xu HG

    更新日期:2019-11-01 00:00:00

  • The effects of uremia and dietary phosphorus on the bone of rats.

    abstract::In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....


    pub_type: 杂志文章


    authors: Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

    更新日期:1990-01-01 00:00:00

  • Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women.

    abstract::The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sinaki M,Itoi E,Wahner HW,Wollan P,Gelzcer R,Mullan BP,Collins DA,Hodgson SF

    更新日期:2002-06-01 00:00:00

  • The relationship between porosity and specific surface in human cortical bone is subject specific.

    abstract::A characteristic relationship for bone between bone volume fraction (BV/TV) and specific surface (BS/TV) has previously been proposed based on 2D histological measurements. This relationship has been suggested to be bone intrinsic, i.e., to not depend on bone type, bone site and health state. In these studies, only li...


    pub_type: 杂志文章


    authors: Lerebours C,Thomas CD,Clement JG,Buenzli PR,Pivonka P

    更新日期:2015-03-01 00:00:00

  • Lack of periosteal apposition in the head and neck of femur after menopause in Chinese women with high risk for hip fractures - A cross-sectional study with QCT.

    abstract::In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal ...


    pub_type: 杂志文章


    authors: Su Y,Wang L,Liu X,Yang M,Yi C,Liu Y,Huang P,Guo Z,Yu A,Cheng X,Wu X,Blake GM,Engelke K

    更新日期:2020-10-01 00:00:00

  • Higher osteoclastic demineralization and highly mineralized cement lines with osteocalcin deposition in a mandibular cortical bone of autosomal dominant osteopetrosis type II: ultrastructural and undecalcified histological investigations.

    abstract::In this study we report on histological and ultrastructural investigations of the mandibular cortical bone in a case of autosomal dominant osteopetrosis type II complicated by mandibular osteomyelitis. Histologically, there was a marked increase in the number and size of osteoclasts on the inner bone surface. An undec...


    pub_type: 杂志文章


    authors: Semba I,Ishigami T,Sugihara K,Kitano M

    更新日期:2000-09-01 00:00:00

  • Aging of mouse intervertebral disc and association with back pain.

    abstract::With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...


    pub_type: 杂志文章


    authors: Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

    更新日期:2019-06-01 00:00:00

  • The genetic architecture of osteoporosis and fracture risk.

    abstract::Osteoporosis and fracture risk are common complex diseases, caused by an interaction of numerous disease susceptibility genes and environmental factors. With the advances in genomic technologies, large-scale genome-wide association studies (GWAS) have been performed which have broadened our understanding of the geneti...


    pub_type: 杂志文章,评审


    authors: Trajanoska K,Rivadeneira F

    更新日期:2019-09-01 00:00:00

  • The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains.

    abstract::Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluatio...


    pub_type: 杂志文章


    authors: Roberts BC,Giorgi M,Oliviero S,Wang N,Boudiffa M,Dall'Ara E

    更新日期:2019-10-01 00:00:00

  • The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis.

    abstract:OBJECTIVE:Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation ...


    pub_type: 杂志文章


    authors: Han L,Yang X,Sun W,Li Z,Ren H,Li B,Zhang R,Zhang D,Shi Z,Liu J,Cao J,Zhang J,Xiong Y

    更新日期:2018-12-01 00:00:00

  • Scoliosis in osteogenesis imperfecta caused by COL1A1/COL1A2 mutations - genotype-phenotype correlations and effect of bisphosphonate treatment.

    abstract::Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...


    pub_type: 杂志文章


    authors: Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

    更新日期:2016-05-01 00:00:00

  • Osteoblast migration into type I collagen gel and differentiation to osteocyte-like cells within a self-produced mineralized matrix: a novel system for analyzing differentiation from osteoblast to osteocyte.

    abstract::Osteoblasts are believed to differentiate into osteocytes, becoming embedded in bone, or to undergo apoptosis after the bone formation phase. The regulation of this terminal differentiation seems to be critical for bone homeostasis. However the mechanism remains unclear and there is no assay system currently available...


    pub_type: 杂志文章


    authors: Uchihashi K,Aoki S,Matsunobu A,Toda S

    更新日期:2013-01-01 00:00:00

  • Effect of a general school-based physical activity intervention on bone mineral content and density: a cluster-randomized controlled trial.

    abstract:BACKGROUND:Specific physical loading leads to enhanced bone development during childhood. A general physical activity program mimicking a real-life situation was successful at increasing general physical health in children. Yet, it is not clear whether it can equally increase bone mineral mass. We performed a cluster-r...


    pub_type: 杂志文章,随机对照试验


    authors: Meyer U,Romann M,Zahner L,Schindler C,Puder JJ,Kraenzlin M,Rizzoli R,Kriemler S

    更新日期:2011-04-01 00:00:00

  • Mechanistic and therapeutic insights gained from studying rare skeletal diseases.

    abstract::Rare bone diseases account for 5% of all birth defects and can cause significant morbidity throughout patients' lives. Significant progress is being made to elucidate the pathophysiological mechanisms underlying these diseases. This paper summarizes presentation highlights of a workshop on Rare Skeletal Diseases conve...


    pub_type: 杂志文章,评审


    authors: Tosi LL,Warman ML

    更新日期:2015-07-01 00:00:00

  • Functional analysis of bone sialoprotein: identification of the hydroxyapatite-nucleating and cell-binding domains by recombinant peptide expression and site-directed mutagenesis.

    abstract::Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...


    pub_type: 杂志文章


    authors: Harris NL,Rattray KR,Tye CE,Underhill TM,Somerman MJ,D'Errico JA,Chambers AF,Hunter GK,Goldberg HA

    更新日期:2000-12-01 00:00:00