Fourier and wavelet analyses of dental radiographs detect trabecular changes in osteoporosis.

abstract：:Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metab...

journal_title：Bone

authors： China SP,Pal S,Chattopadhyay S,Porwal K,Kushwaha S,Bhattacharyya S,Mittal M,Gurjar AA,Barbhuyan T,Singh AK,Trivedi AK,Gayen JR,Sanyal S,Chattopadhyay N

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

journal_title：Bone

authors： Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

更新日期：2021-01-06 00:00:00

abstract：INTRODUCTION:High plasma homocysteine (Hcy) levels have been associated with increased risk of fracture. Since Hcy has been shown to induce apoptosis in many cell types, including vascular endothelial cells, we hypothesized that Hcy would have a similar apoptotic effect on osteoblasts, leading to osteoporosis by reduci...

journal_title：Bone

authors： Kim DJ,Koh JM,Lee O,Kim NJ,Lee YS,Kim YS,Park JY,Lee KU,Kim GS

更新日期：2006-09-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:Intermittent PTH increases trabecular bone mass in vivo by stimulating osteoblast differentiation to increase bone formation. The molecular events that mediate the anabolic effect of PTH on osteoblasts have not been characterized. We investigated if PTH regulated mRNA expression of proto-oncogenes, c-fos, c-jun, and c...

journal_title：Bone

authors： Onyia JE,Bidwell J,Herring J,Hulman J,Hock JM

更新日期：1995-11-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：:To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout. Although suppression of the ligand to the ERs (i.e., estradiol) after menopause or gonadectomy in females...

journal_title：Bone

authors： Sims NA,Dupont S,Krust A,Clement-Lacroix P,Minet D,Resche-Rigon M,Gaillard-Kelly M,Baron R

更新日期：2002-01-01 00:00:00

abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

journal_title：Bone

authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

更新日期：2021-02-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

journal_title：Bone

authors： Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...

journal_title：Bone

authors： Rousseau JC,Bertholon C,Chapurlat R,Szulc P

更新日期：2020-03-01 00:00:00

abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...

journal_title：Bone

authors： Hutchison C,Pilote M,Roy S

更新日期：2007-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D [1,25(OH)(2)D] insufficiency appears to be associated with several age-related diseases. Insufficient levels of serum 25-hydroxyvitamin D has been shown to lead to the progression of osteoarthritis (OA) while underlying biological mechanisms remain largely unknown. In this study, we sought to d...

journal_title：Bone

authors： Shen M,Luo Y,Niu Y,Chen L,Yuan X,Goltzman D,Chen N,Miao D

更新日期：2013-08-01 00:00:00

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00

abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

journal_title：Bone

authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

更新日期：2007-04-01 00:00:00

abstract：:Death certification data has shown that death rates due to Paget's disease of bone and osteosarcoma in older people (assumed to be attributable to Paget's) declined in the latter part of the 19th and in the early 20th century, suggesting that there may be a secular trend toward less severe disease. We have reviewed a ...

journal_title：Bone

authors： Cundy T,McAnulty K,Wattie D,Gamble G,Rutland M,Ibbertson HK

更新日期：1997-01-01 00:00:00

abstract：:Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...

journal_title：Bone

authors： Janssens K,de Vernejoul MC,de Freitas F,Vanhoenacker F,Van Hul W

更新日期：2005-03-01 00:00:00

abstract：:We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...

journal_title：Bone

authors： Davis JW,Ross PD,Johnson NE,Wasnich RD

更新日期：1995-10-01 00:00:00

abstract：:Approximately 5% of all military recruits incur stress fracture injuries during intense physical training, predominately in the lower extremity. We compared young men and women with stress fracture injury (subjects) to a matched group of uninjured volunteers (controls) during a summer training program at the United St...

journal_title：Bone

authors： Armstrong DW 3rd,Rue JP,Wilckens JH,Frassica FJ

更新日期：2004-09-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：:Paralysis of the masticatory muscles using botulinum toxin (BTX) is a common treatment for cosmetic reduction of the masseters as well as for conditions involving muscle spasm and pain. The effects of this treatment on mastication have not been evaluated, and claims that the treatment unloads the jaw joint and mandibl...

journal_title：Bone

authors： Rafferty KL,Liu ZJ,Ye W,Navarrete AL,Nguyen TT,Salamati A,Herring SW

更新日期：2012-03-01 00:00:00

abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

journal_title：Bone

authors： Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

更新日期：2005-03-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

journal_title：Bone

authors： de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

更新日期：2021-01-07 00:00:00

abstract：:The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mechanical property that describes how much deformation a trabecula can s...

journal_title：Bone

authors： Hernandez CJ,Tang SY,Baumbach BM,Hwu PB,Sakkee AN,van der Ham F,DeGroot J,Bank RA,Keaveny TM

更新日期：2005-12-01 00:00:00

abstract：:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...

journal_title：Bone

authors： Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JY

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...

journal_title：Bone

authors： Kemmler W,Kohl M,Fröhlich M,Schoene D,von Stengel S

更新日期：2021-01-01 00:00:00

abstract：:Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...

journal_title：Bone

authors： Pauly S,Luttosch F,Morawski M,Haas NP,Schmidmaier G,Wildemann B

更新日期：2009-09-01 00:00:00

abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

journal_title：Bone

authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

更新日期：1998-06-01 00:00:00

abstract：:FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...

journal_title：Bone

authors： Varanasi SS,Datta HK

更新日期：2005-02-01 00:00:00

abstract：:The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to affect bone homeostasis as mediators in the so-called entero-osseous axis. We examined the contributions of endogenous GIP and GLP-1, resp...

journal_title：Bone

authors： Helsted MM,Gasbjerg LS,Lanng AR,Bergmann NC,Stensen S,Hartmann B,Christensen MB,Holst JJ,Vilsbøll T,Rosenkilde MM,Knop FK

更新日期：2020-11-01 00:00:00