Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function.

abstract：:Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...

journal_title：Bone

authors： Wang X,Allen MR,Burr DB,Lavernia EJ,Jeremić B,Fyhrie DP

更新日期：2008-10-01 00:00:00

abstract：:The benefit of impact-loading activity for bone strength depends on whether the additional bone mineral content (BMC) accrued at loaded sites is due to an increased bone size, volumetric bone mineral density (vBMD) or both. Using magnetic resonance imaging (MRI) and dual energy X-ray absorptiometry (DXA), the aim of t...

journal_title：Bone

authors： Ducher G,Courteix D,Même S,Magni C,Viala JF,Benhamou CL

更新日期：2005-10-01 00:00:00

abstract：:Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...

journal_title：Bone

authors： Li Z,Zhou Z,Yellowley CE,Donahue HJ

更新日期：1999-12-01 00:00:00

abstract：:Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects, yet the underlying mechanisms and recovery potential remain unclear. Wnt/β-catenin signalling is integral to the regulation of osteogenesis, adipogenesis and haematopoiesis; using a rat model, the current study investi...

journal_title：Bone

authors： Georgiou KR,King TJ,Scherer MA,Zhou H,Foster BK,Xian CJ

更新日期：2012-06-01 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00

abstract：:Evidence indicates that astronauts experience significant bone loss during space mission. Recently, we used the NASA developed rotary cell culture system (RCCS) to simulate microgravity (μXg) conditions and demonstrated increased osteoclastogenesis in mouse bone marrow cultures. Autophagy is a cellular recycling proce...

journal_title：Bone

authors： Sambandam Y,Townsend MT,Pierce JJ,Lipman CM,Haque A,Bateman TA,Reddy SV

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...

journal_title：Bone

authors： Tenne M,McGuigan F,Jansson L,Gerdhem P,Obrant KJ,Luthman H,Akesson K

更新日期：2008-04-01 00:00:00

abstract：:The incidence of hip fractures in Oslo has shown a secular increase during the past decades. The main aims of the present study were to report the current incidence of hip fractures in Oslo and to determine whether there is a seasonal variation in the occurrence of fractures. Using the electronic diagnosis registers a...

journal_title：Bone

authors： Lofthus CM,Osnes EK,Falch JA,Kaastad TS,Kristiansen IS,Nordsletten L,Stensvold I,Meyer HE

更新日期：2001-11-01 00:00:00

abstract：:Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch indivi...

journal_title：Bone

authors： Oei L,Estrada K,Duncan EL,Christiansen C,Liu CT,Langdahl BL,Obermayer-Pietsch B,Riancho JA,Prince RL,van Schoor NM,McCloskey E,Hsu YH,Evangelou E,Ntzani E,Evans DM,Alonso N,Husted LB,Valero C,Hernandez JL,Lewis JR,

更新日期：2014-02-01 00:00:00

abstract：:Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...

journal_title：Bone

authors： Di Fiore R,Marcatti M,Drago-Ferrante R,D'Anneo A,Giuliano M,Carlisi D,De Blasio A,Querques F,Pastore L,Tesoriere G,Vento R

更新日期：2014-03-01 00:00:00

abstract：:Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent...

journal_title：Bone

authors： Wenger KH,Freeman JD,Fulzele S,Immel DM,Powell BD,Molitor P,Chao YJ,Gao HS,Elsalanty M,Hamrick MW,Isales CM,Yu JC

更新日期：2010-10-01 00:00:00

abstract：:The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...

journal_title：Bone

authors： Roberts SJ,van Gastel N,Carmeliet G,Luyten FP

更新日期：2015-01-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00

abstract：:Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...

journal_title：Bone

authors： Pavey GJ,Qureshi AT,Tomasino AM,Honnold CL,Bishop DK,Agarwal S,Loder S,Levi B,Pacifici M,Iwamoto M,Potter BK,Davis TA,Forsberg JA

更新日期：2016-09-01 00:00:00

abstract：:Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...

journal_title：Bone

authors： Janssens K,de Vernejoul MC,de Freitas F,Vanhoenacker F,Van Hul W

更新日期：2005-03-01 00:00:00

abstract：:A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which...

journal_title：Bone

authors： Katoh-Fukui Y,Baba T,Sato T,Otake H,Nagakui-Noguchi Y,Shindo M,Suyama M,Ohkawa Y,Tsumura H,Morohashi KI,Fukami M

更新日期：2019-03-01 00:00:00

abstract：UNLABELLED:We evaluated the effect of glucocorticoids (GC) and growth hormone (GH) on cortical and cancellous bone turnover in adult rats using random vertical sections giving valid measurements of bone surfaces and bone formation parameters. GH administration could reverse GC-induced osteopenia and low bone turnover o...

journal_title：Bone

authors： Ortoft G,Andreassen TT,Oxlund H

更新日期：2005-01-01 00:00:00

abstract：:Clinically, osteopenia or low bone mass has been observed in a variety of chronic inflammatory diseases, and elevated proinflammatory mediators have implicated this process. The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation. Time-release pellets designed to...

journal_title：Bone

authors： Smith BJ,Lerner MR,Bu SY,Lucas EA,Hanas JS,Lightfoot SA,Postier RG,Bronze MS,Brackett DJ

更新日期：2006-03-01 00:00:00

abstract：:The role of vitamin D receptor (VDR) gene polymorphisms in the determination of bone mass and bone turnover is controversial in women. The aim of the study was to determine whether VDR polymorphisms are associated with indices of bone mineral density (BMD) (by dual-energy X-ray absorptiometry and by ultrasound) and/or...

journal_title：Bone

authors： Van Pottelbergh I,Goemaere S,De Bacquer D,De Paepe A,Kaufman M

更新日期：2002-11-01 00:00:00

abstract：:Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...

journal_title：Bone

authors： Harvey NC,Glüer CC,Binkley N,McCloskey EV,Brandi ML,Cooper C,Kendler D,Lamy O,Laslop A,Camargos BM,Reginster JY,Rizzoli R,Kanis JA

更新日期：2015-09-01 00:00:00

abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...

journal_title：Bone

authors： Dai JC,He P,Chen X,Greenfield EM

更新日期：2006-04-01 00:00:00

abstract：:The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...

journal_title：Bone

authors： Brotto M,Bonewald L

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Spinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI. METHOD...

journal_title：Bone

authors： Edwards WB,Schnitzer TJ,Troy KL

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00

abstract：:Bone healing is a complex multi-step process, which depends on the position and size of the lesion, and on the mechanical stability of the wounded area. To address more specifically the mechanisms involved in cortical bone healing, we created drill-hole defects in the cortex of mouse femur, a lesion that triggers intr...

journal_title：Bone

authors： Monfoulet L,Malaval L,Aubin JE,Rittling SR,Gadeau AP,Fricain JC,Chassande O

更新日期：2010-02-01 00:00:00

abstract：:MLO-A5 cells are a fully differentiated osteoblastic cell line with the ability to rapidly synthesise mineralised extracellular matrix (ECM). We used MLO-A5 cells to develop a system for studying the mechanical modulation of bone matrix formation in 3D using a cyclic compressive loading stimulus. Polyurethane (PU) ope...

journal_title：Bone

authors： Sittichockechaiwut A,Scutt AM,Ryan AJ,Bonewald LF,Reilly GC

更新日期：2009-05-01 00:00:00

abstract：:The uncarboxylated form of the osteoblast-specific secreted molecule osteocalcin is a hormone favoring glucose handling and increasing energy expenditure. As a result, the absence of osteocalcin leads to glucose intolerance in mice, while genetically modified mice with an increase in uncarboxylated osteocalcin are pro...

journal_title：Bone

authors： Ferron M,McKee MD,Levine RL,Ducy P,Karsenty G

更新日期：2012-02-01 00:00:00

abstract：:Serum PINP has emerged as a reliable marker of bone turnover in humans and is routinely used to monitor bone formation. However, the effects of PTH (1-34) on bone turnover have not been evaluated following short-term treatment. We present data demonstrating that PINP is an early serum biomarker in the rat for assessin...

journal_title：Bone

authors： Hale LV,Galvin RJ,Risteli J,Ma YL,Harvey AK,Yang X,Cain RL,Zeng Q,Frolik CA,Sato M,Schmidt AL,Geiser AG

更新日期：2007-04-01 00:00:00

abstract：:During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...

journal_title：Bone

authors： Mühlbauer RC,Lozano A,Palacio S,Reinli A,Felix R

更新日期：2003-04-01 00:00:00

abstract：:A computerised technique is described for the quantitative assessment of resorption cavities in iliac trabecular bone. Using an Ibas II image analyser, the original bone surface, eroded by bone resorbing cells, is reconstructed using a curve fitting technique that maintains a smooth continuity with the trabecular bone...

journal_title：Bone

authors： Garrahan NJ,Croucher PI,Compston JE

更新日期：1990-01-01 00:00:00