Common herbs, essential oils, and monoterpenes potently modulate bone metabolism.

abstract：:Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiovascular events, specific SGLT2Is have been associated with an increas...

journal_title：Bone

authors： Thrailkill KM,Bunn RC,Uppuganti S,Ray P,Garrett K,Popescu I,Pennings JS,Fowlkes JL,Nyman JS

更新日期：2020-04-01 00:00:00

abstract：:Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...

journal_title：Bone

authors： Les CM,Spence CA,Vance JL,Christopherson GT,Patel B,Turner AS,Divine GW,Fyhrie DP

更新日期：2004-09-01 00:00:00

abstract：:Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...

journal_title：Bone

authors： Jasper LE,Deramond H,Mathis JM,Belkoff SM

更新日期：1999-08-01 00:00:00

abstract：:Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium-phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2...

journal_title：Bone

authors： Wang B,Yang Y,Liu L,Blair HC,Friedman PA

更新日期：2013-01-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00

abstract：:The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...

journal_title：Bone

authors： Brotto M,Bonewald L

更新日期：2015-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can self-renew and differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. It's reported that bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic BMPs to initiate the commitment of MSCs to osteoblast lineage. Cyclooxygenase-2 (COX-2) is critical...

journal_title：Bone

authors： Wang JH,Liu YZ,Yin LJ,Chen L,Huang J,Liu Y,Zhang RX,Zhou LY,Yang QJ,Luo JY,Zuo GW,Deng ZL,He BC

更新日期：2013-11-01 00:00:00

abstract：:Cylindrical trabecular bone specimens (d = 7 mm) were drilled in a vertical direction from the central part of the third vertebral body (L3) from 23 normal individuals aged 15-87 years (10 males and 13 females). The bone samples were embedded in methylmetacrylate and sawn in 400 microns thick sections with an arbitrar...

journal_title：Bone

authors： Mosekilde L

更新日期：1988-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

journal_title：Bone

authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

更新日期：2020-09-01 00:00:00

abstract：:This paper describes a new alternative for individualized mechanical analysis of bone trabecular structure. This new method closes the gap between the classic homogenization approach that is applied to macro-scale models and the modern micro-finite element method that is applied directly to micro-scale high-resolution...

journal_title：Bone

authors： Podshivalov L,Fischer A,Bar-Yoseph PZ

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00

abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...

journal_title：Bone

authors： Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

更新日期：2014-10-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed to...

journal_title：Bone

authors： Mys K,Stockmans F,Vereecke E,van Lenthe GH

更新日期：2018-09-01 00:00:00

abstract：:This review begins with an introduction to the malignant bone tumor, osteosarcoma [OS] and then moves to a discussion of the commonly used vectors for gene transfer. We first briefly highlight non-viral vectors including polymeric and liposomal delivery systems but concentrate predominantly on the 5 leading viral vect...

journal_title：Bone

authors： Witlox MA,Lamfers ML,Wuisman PI,Curiel DT,Siegal GP

更新日期：2007-04-01 00:00:00

abstract：:FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein convertases in a pre-release degradative pathway. We have here examined the metabolism of FGF23 in a model bone cell line, IDG-SW3, prior to and following differentiation, as w...

journal_title：Bone

authors： Yamamoto H,Ramos-Molina B,Lick AN,Prideaux M,Albornoz V,Bonewald L,Lindberg I

更新日期：2016-03-01 00:00:00

abstract：:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...

journal_title：Bone

authors： Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JY

更新日期：2003-05-01 00:00:00

abstract：:Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...

journal_title：Bone

authors： Kannus P,Palvanen M,Niemi S,Sievänen H,Parkkari J

更新日期：2009-04-01 00:00:00

abstract：:Glucocorticoids (GC) are used for the treatment of a wide spectrum of diseases because of their potent anti-inflammatory and immunosuppressive effects, and they are serious and common causes of secondary osteoporosis. Administration of intermittent parathyroid hormone (PTH) may induce formation of new bone and may cou...

journal_title：Bone

authors： Oxlund H,Ortoft G,Thomsen JS,Danielsen CC,Ejersted C,Andreassen TT

更新日期：2006-08-01 00:00:00

abstract：:In the development of 3-dimensional cell-polymer matrices for tissue engineering, the ability of osteoblast cells to maintain their phenotypic properties and form a mineralized matrix while seeded on the polymer surface is very important. Osteoblast cell differentiation and bone formation using rat calvaria cells were...

journal_title：Bone

authors： Laurencin CT,Attawia MA,Elgendy HE,Herbert KM

更新日期：1996-07-01 00:00:00

abstract：:Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...

journal_title：Bone

authors： O'Brien EA,Williams JH,Marshall MJ

更新日期：2001-02-01 00:00:00

abstract：:With age, alterations occurring in bone quality, quantity, and microarchitecture affect the resistance of trabecular bone to local failure. The clinical implications of these changes are evident by the observed exponential increase in fracture incidence with age. Although age-related development of skeletal fragility ...

journal_title：Bone

authors： Nagaraja S,Lin AS,Guldberg RE

更新日期：2007-04-01 00:00:00

abstract：:Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...

journal_title：Bone

authors： Braithwaite V,Pettifor JM,Prentice A

更新日期：2013-03-01 00:00:00

abstract：:One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...

journal_title：Bone

authors： Peng ZQ,Väänänen HK,Zhang HX,Tuukkanen J

更新日期：1997-03-01 00:00:00

abstract：:Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...

journal_title：Bone

authors： Wiren KM,Zhang XW,Olson DA,Turner RT,Iwaniec UT

更新日期：2012-11-01 00:00:00

abstract：:A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involve...

journal_title：Bone

authors： Yazdanpanah N,Zillikens MC,Rivadeneira F,de Jong R,Lindemans J,Uitterlinden AG,Pols HA,van Meurs JB

更新日期：2007-12-01 00:00:00

abstract：:Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...

journal_title：Bone

authors： Durand M,Boire G,Komarova SV,Dixon SJ,Sims SM,Harrison RE,Nabavi N,Maria O,Manolson MF,Mizianty M,Kurgan L,de Brum-Fernandes AJ

更新日期：2011-03-01 00:00:00

abstract：:Levels of HtrA1 protein in cartilage have been reported to elevate in joints of human osteoarthritis patients. To understand roles of HtrA1 in normal osteogenesis as well as in pathogenesis of arthritis, we examine HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by ex...

journal_title：Bone

authors： Tsuchiya A,Yano M,Tocharus J,Kojima H,Fukumoto M,Kawaichi M,Oka C

更新日期：2005-09-01 00:00:00

abstract：:The present review summarizes the pathogenic mechanisms leading to hip fracture based on epidemiological, experimental, and controlled clinical studies. The estimated lifetime risk of hip fracture is about 14% in postmenopausal women and 6% in men. The incidence of hip fractures increases exponentially with aging, but...

journal_title：Bone

authors： Lauritzen JB

更新日期：1996-01-01 00:00:00

abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

journal_title：Bone

authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

更新日期：1990-01-01 00:00:00