Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma.

abstract：BACKGROUND:Bone allografts carry a risk of infection, so terminal sterilization by gamma irradiation at 25kGy is recommended; but is deleterious to bone quality. Contemporary bone banking significantly reduces initial allograft bioburden, questioning the need to sterilize at 25kGy. METHODS:We inoculated allograft bone...

journal_title：Bone

authors： Nguyen H,Cassady AI,Bennett MB,Gineyts E,Wu A,Morgan DA,Forwood MR

更新日期：2013-11-01 00:00:00

abstract：:We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...

journal_title：Bone

authors： Fang MA,Frost PJ,Iida-Klein A,Hahn TJ

更新日期：1991-01-01 00:00:00

abstract：:Over 60% of our severely combat-injured patient population develops radiographically apparent heterotopic ossification. Nearly a third of these require surgical excision of symptomatic lesions, a procedure that is fraught with complications, and delays or regresses functional rehabilitation in many cases. Unfortunatel...

journal_title：Bone

authors： Crane NJ,Polfer E,Elster EA,Potter BK,Forsberg JA

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures. METHODS:A population of Caucasian women (30-90 years), enrolled from 2013 to 2016, underwent dual X-ray absorpti...

journal_title：Bone

authors： Adami G,Arioli G,Bianchi G,Brandi ML,Caffarelli C,Cianferotti L,Gatti D,Girasole G,Gonnelli S,Manfredini M,Muratore M,Quarta E,Quarta L

更新日期：2020-05-01 00:00:00

abstract：:Both mechanical loading and nitric oxide (NO) have positive influences on bone mass. NO production is induced by mechanical strain via upregulation of eNOS mRNA and protein, the predominant NOS in adult bone. At the same time, strain causes decreased expression of RANKL, a factor critical for osteoclastogenesis. In th...

journal_title：Bone

authors： Rahnert J,Fan X,Case N,Murphy TC,Grassi F,Sen B,Rubin J

更新日期：2008-07-01 00:00:00

abstract：:Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma of bone and then treated animals with X-radiation therapy. We ...

journal_title：Bone

authors： Margulies BS,DeBoyace SD,Damron TA,Allen MJ

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to assess age-related changes in the human spine by use of established static histomorphometry, and to determine how these static histomorphometric measures are interrelated in human cancellous bone tissue. The material comprised normal human lumbar vertebral bodies (L-2) from 12 women...

journal_title：Bone

authors： Thomsen JS,Ebbesen EN,Mosekilde L

更新日期：2000-07-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a progressive muscle disorder caused by genetic mutations of the dystrophin encoding gene. In the absence of functional dystrophin, DMD patients suffer from muscle inflammation and wasting, as well as compromised bone health with increased risk of fracture. The use of high dose glu...

journal_title：Bone

authors： Yoon SH,Grynpas M,Mitchell J

更新日期：2019-04-01 00:00:00

abstract：:Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical propertie...

journal_title：Bone

authors： Wear KA,Nagaraja S,Dreher ML,Sadoughi S,Zhu S,Keaveny TM

更新日期：2017-10-01 00:00:00

abstract：:The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...

journal_title：Bone

authors： Roschger P,Gupta HS,Berzlanovich A,Ittner G,Dempster DW,Fratzl P,Cosman F,Parisien M,Lindsay R,Nieves JW,Klaushofer K

更新日期：2003-03-01 00:00:00

abstract：:Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...

journal_title：Bone

authors： Kellenberger S,Muller K,Richener H,Bilbe G

更新日期：1998-05-01 00:00:00

abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

journal_title：Bone

authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

更新日期：2011-10-01 00:00:00

abstract：:Hypophosphatasia (HPP) is an inherited disorder characterized by defective bone mineralization caused by mutations in the alkaline phosphatase gene (ALPL). Clinically, the disease spans a great continuum of disease severity and six forms can be distinguished according to the age of onset. The most severe is the autoso...

journal_title：Bone

authors： Watanabe A,Satoh S,Fujita A,Naing BT,Orimo H,Shimada T

更新日期：2014-03-01 00:00:00

abstract：:Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a bet...

journal_title：Bone

authors： van Lierop AH,Appelman-Dijkstra NM,Papapoulos SE

更新日期：2017-03-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...

journal_title：Bone

authors： Wang L,Shao YY,Ballock RT

更新日期：2005-09-01 00:00:00

abstract：:Genetic mouse models are widely used for understanding human diseases but we know much less about the anatomical structure of the auditory ossicles in the mouse than we do about human ossicles. Furthermore, current studies have mainly focused on disease conditions such as osteomalacia and rickets in patients with hypo...

journal_title：Bone

authors： Lv K,Huang H,Yi X,Chertoff ME,Li C,Yuan B,Hinton RJ,Feng JQ

更新日期：2017-10-01 00:00:00

abstract：:Obesity in humans is associated with increased bone mass. Leptin, a hormone produced by fat cells, functions as a sentinel of energy balance, and may mediate the putative positive effects of body mass on bone. We performed studies in male C57Bl/6 wild type (WT) and leptin-deficient ob/ob mice to determine whether body...

journal_title：Bone

authors： Iwaniec UT,Dube MG,Boghossian S,Song H,Helferich WG,Turner RT,Kalra SP

更新日期：2009-03-01 00:00:00

abstract：:The effect of clodronate on healing of the fracture of osteopenic bone was studied in rats. A total of 165 female rats (14 +/- 1 weeks, 216 +/- 2 g) were divided into five fracture groups (n = 30), and a neurectomized group (n = 15). Osteopenia (op) was induced by right sciatic neurectomy 4 weeks before the fracture. ...

journal_title：Bone

authors： Tarvainen R,Olkkonen H,Nevalainen T,Hyvönen P,Arnala I,Alhava E

更新日期：1994-11-01 00:00:00

abstract：:In an effort to elucidate the interplay between mechanical load and proteolytic gene expression in arthritic tissue degradation, we investigated cellular morphology and mRNA levels of matrix metalloproteinase-13 (MMP-13) genes under mechanical stress in human MH7A synovial cells. The cells were isolated from the knee ...

journal_title：Bone

authors： Sun HB,Yokota H

更新日期：2001-04-01 00:00:00

abstract：:A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which...

journal_title：Bone

authors： Katoh-Fukui Y,Baba T,Sato T,Otake H,Nagakui-Noguchi Y,Shindo M,Suyama M,Ohkawa Y,Tsumura H,Morohashi KI,Fukami M

更新日期：2019-03-01 00:00:00

abstract：:Bone tissue undergoes permanent and lifelong remodeling with a concerted action of bone-building osteoblasts and bone-resorbing osteoclasts. A precise cooperation between those two cell types is critical in the complex process of bone renewal. Galectin-3 is a member of the β-galactoside-binding lectin family playing m...

journal_title：Bone

authors： Simon D,Derer A,Andes FT,Lezuo P,Bozec A,Schett G,Herrmann M,Harre U

更新日期：2017-12-01 00:00:00

abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

journal_title：Bone

authors： Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

更新日期：2020-08-01 00:00:00

abstract：:Bone mineral "density" (BMD) measured by dual-energy X-ray absorptiometry (DEXA) does not represent the volumetric density (grams per cubic centimeter), but rather the areal density (grams per square centimeter). This distinction is important during growth. The purpose of this study was to measure vertebral dimensions...

journal_title：Bone

authors： Ott SM,O'Hanlan M,Lipkin EW,Newell-Morris L

更新日期：1997-06-01 00:00:00

abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

journal_title：Bone

authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

更新日期：2012-09-01 00:00:00

abstract：:Osteoporosis is a major cause of disability in the United States. Numerous factors contribute to the decline in bone mineral density (BMD) that characterizes this disease, and the importance of heredity is now widely appreciated. We evaluated the joint contributions of genes and environmental factors on variation in B...

journal_title：Bone

authors： Mitchell BD,Kammerer CM,Schneider JL,Perez R,Bauer RL

更新日期：2003-11-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00

abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...

journal_title：Bone

authors： Cochran DL,Abernathy CK

更新日期：1988-01-01 00:00:00

abstract：:Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to increases in fatigue microdamage. To investigate how bisphosphonate effects influence changes in bone volume and microdamage in the long term, a strain-adaptive model of bone remodeling and microdamage balance was...

journal_title：Bone

authors： Nyman JS,Yeh OC,Hazelwood SJ,Martin RB

更新日期：2004-07-01 00:00:00

abstract：:Pregnancy is a common physiological event that could affect peak bone mass and the risk of developing osteoporosis later in life. There have been few longitudinal studies over a complete reproductive cycle of any size to show whether bone mineral density (BMD) changes. We have measured BMD by dual-energy X-ray absorpt...

journal_title：Bone

authors： Kaur M,Pearson D,Godber I,Lawson N,Baker P,Hosking D

更新日期：2003-04-01 00:00:00