A new method of comprehensive static histomorphometry applied on human lumbar vertebral cancellous bone.

abstract：:FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...

journal_title：Bone

authors： Varanasi SS,Datta HK

更新日期：2005-02-01 00:00:00

abstract：:Recent studies have indicated a critical role for vascular endothelial growth factor (VEGF) during the process of endochondral ossification, in particular in coupling cartilage resorption with bone formation. Therefore, we studied the chemoattractive and proliferative properties of human VEGF-A on primary human osteob...

journal_title：Bone

authors： Mayr-Wohlfart U,Waltenberger J,Hausser H,Kessler S,Günther KP,Dehio C,Puhl W,Brenner RE

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months,...

journal_title：Bone

authors： Enlund-Cerullo M,Hauta-Alus H,Valkama S,Rosendahl J,Andersson S,Mäkitie O,Holmlund-Suila E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular micr...

journal_title：Bone

authors： Vom Scheidt A,Grisolia Seifert EF,Pokrant C,Püschel K,Amling M,Busse B,Milovanovic P

更新日期：2019-05-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Using immunohistology with two specific antisera raised against N-terminal parathyroid hormone-related protein (PTHrP) and in situ hybridization (riboprobe to common coding exon), evidence is provided for the expression of PTHrP by mouse, rabbit, and human osteoclasts derived from several in vitro and in vivo sources....

journal_title：Bone

authors： Kartsogiannis V,Udagawa N,Ng KW,Martin TJ,Moseley JM,Zhou H

更新日期：1998-03-01 00:00:00

abstract：:Three distinct osteoblastic cell lines (KS418, KS460, and KS483) were subcloned from the mouse osteoblastic KS-4 cells, which possessed the abilities not only to differentiate into mature osteoblasts, but also to support osteoclast differentiation in coculture with spleen cells. The order of the magnitude of the basal...

journal_title：Bone

authors： Yamashita T,Ishii H,Shimoda K,Sampath TK,Katagiri T,Wada M,Osawa T,Suda T

更新日期：1996-11-01 00:00:00

abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

journal_title：Bone

authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

更新日期：2007-04-01 00:00:00

abstract：:Anterior cruciate ligament (ACL) tears are a common sports-related knee injury that increases the risk of developing post-traumatic osteoarthritis (OA). During OA progression bone microarchitecture changes in the affected knee, however, little is known about bone microarchitecture in knees with early stage OA. The pur...

journal_title：Bone

authors： Kroker A,Bhatla JL,Emery CA,Manske SL,Boyd SK

更新日期：2018-06-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...

journal_title：Bone

authors： Xiao H,Xie X,Wen Y,Tan Y,Shangguan Y,Li B,Magdalou J,Wang H,Chen L

更新日期：2020-04-01 00:00:00

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:U.S. Army Basic Combat Training (BCT) is a physically-demanding program at the start of military service. Whereas animal studies have shown that increased mechanical loading rapidly alters bone structure, there is limited evidence of changes in bone density and structure in humans exposed to a brief period o...

journal_title：Bone

authors： Hughes JM,Gaffney-Stomberg E,Guerriere KI,Taylor KM,Popp KL,Xu C,Unnikrishnan G,Staab JS,Matheny RW Jr,McClung JP,Reifman J,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...

journal_title：Bone

authors： Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:WNT signaling plays a major role in bone and cartilage metabolism. Impaired WNT/β-catenin signaling leads to early-onset osteoporosis, but specific features in bone and other tissues remain inadequately characterized. We have identified two large Finnish families with early-onset osteoporosis due to a hetero...

journal_title：Bone

authors： Mäkitie RE,Niinimäki T,Nieminen MT,Schalin-Jäntti C,Niinimäki J,Mäkitie O

更新日期：2017-08-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...

journal_title：Bone

authors： Imel EA,Liu Z,McQueen AK,Acton D,Acton A,Padgett LR,Peacock M,Econs MJ

更新日期：2016-05-01 00:00:00

abstract：:Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40...

journal_title：Bone

authors： Kung AW,Yeung SS,Lau KS

更新日期：1998-04-01 00:00:00

abstract：:Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...

journal_title：Bone

authors： Quinn JM,Whitty GA,Byrne RJ,Gillespie MT,Hamilton JA

更新日期：2002-01-01 00:00:00

abstract：:Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...

journal_title：Bone

authors： Janssens K,de Vernejoul MC,de Freitas F,Vanhoenacker F,Van Hul W

更新日期：2005-03-01 00:00:00

abstract：:Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the tibia, resists loss of neutral lipid with acute, 48-hour fasting in rats. The mechanisms underlying this phenomenon and its seemingly distinct...

journal_title：Bone

authors： Scheller EL,Khandaker S,Learman BS,Cawthorn WP,Anderson LM,Pham HA,Robles H,Wang Z,Li Z,Parlee SD,Simon BR,Mori H,Bree AJ,Craft CS,MacDougald OA

更新日期：2019-01-01 00:00:00

abstract：:Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in patients with osteoarthritis and fracture of the femoral neck are described. Femoral heads were obtained from patients who had surgery for the treatment of femoral neck fracture or total hip replacement for...

journal_title：Bone

authors： Fazzalari NL,Darracott J,Vernon-Roberts B

更新日期：1985-01-01 00:00:00

abstract：:Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignancies resistant to standard treatment we assessed the effect of saracatinib on bone turnover. Fifty-one patients were randomized in...

journal_title：Bone

authors： Hannon RA,Finkelman RD,Clack G,Iacona RB,Rimmer M,Gossiel F,Baselga J,Eastell R

更新日期：2012-04-01 00:00:00

abstract：:Background and Purpose Radiotherapy is known to produce long-term skeletal complications. We aim to evaluate the biomechanical effect on femoral neck bone from hypothetical eccentric loads on pre- and post-radiotherapy CT-images for patients treated for rectal cancer. MATERIAL AND METHODS:Pre- and post-radiotherapy C...

journal_title：Bone

authors： Almendros-Abellán VM,Castro-García M,Canales-Vázquez J,Berenguel-Herraiz P,Sabater S

更新日期：2021-01-26 00:00:00

abstract：:Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...

journal_title：Bone

authors： Wang X,Allen MR,Burr DB,Lavernia EJ,Jeremić B,Fyhrie DP

更新日期：2008-10-01 00:00:00

abstract：:Combat-related heterotopic ossification (HO) has emerged as a common and problematic complication of modern wartime extremity injuries, contributing to substantial patient morbidity and loss of function. We have previously reported that HO-forming patients exhibit a more pronounced systemic and local inflammatory resp...

journal_title：Bone

authors： Davis TA,Lazdun Y,Potter BK,Forsberg JA

更新日期：2013-09-01 00:00:00

abstract：:Bone remodeling is a process involving both dynamic and static bone strain. Although there exist numerous studies on the effect of dynamic strain on implant stability and bone remodeling, the effect of static strain has yet to be clarified. Hence, for this purpose, the effect of static bone strain on implant stability...

journal_title：Bone

authors： Halldin A,Jimbo R,Johansson CB,Wennerberg A,Jacobsson M,Albrektsson T,Hansson S

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To evaluate the effects of different definitions of glucocorticoid (GC) exposure on the magnitude and pattern of fracture risk using the same dataset. METHODS:Data from patients with rheumatoid arthritis (RA) were extracted from the Clinical Practice Research Datalink, a primary care database with electronic h...

journal_title：Bone

authors： Robinson DE,van Staa TP,Dennison EM,Cooper C,Dixon WG

更新日期：2018-12-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:We described a chick periosteal osteogenesis model at the light microscopic level and biochemically. To confirm that morphologically identifiable bone is being formed, we performed an ultrastructural study of this model. Samples of freshly dissected periostea, as well as whole calvariae, were fixed in glutaraldehyde. ...

journal_title：Bone

authors： Tenenbaum HC,Palangio KG,Holmyard DP,Pritzker KP

更新日期：1986-01-01 00:00:00

abstract：:Diabetes is associated with a number of lower extremity orthopedic conditions and complications including fractures, Charcot neuroarthropathy, plantar ulcers, and infection. These complications are of significant clinical concern in terms of morbidity, mortality, and socioeconomic costs. A review of each condition is ...

journal_title：Bone

authors： Gehling DJ,Lecka-Czernik B,Ebraheim NA

更新日期：2016-01-01 00:00:00

abstract：:The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were us...

journal_title：Bone

authors： Panseri S,Russo A,Sartori M,Giavaresi G,Sandri M,Fini M,Maltarello MC,Shelyakova T,Ortolani A,Visani A,Dediu V,Tampieri A,Marcacci M

更新日期：2013-10-01 00:00:00