当前位置： SCI文献检索 > BONE期刊下所有文献 > Growth, bone health & ambulatory status of boys with DMD treated with daily vs. intermittent oral glucocorticoid regimen.

Growth, bone health & ambulatory status of boys with DMD treated with daily vs. intermittent oral glucocorticoid regimen.

Abstract：

:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growth, body mass, bone mineral density (BMD), vertebral fractures (VF) and ambulatory status in boys with DMD on daily (DAILY) or intermittent (INTERMITTENT), oral GC regimens. A convenience sample of 50 DMD boys from two centres was included in the study; 25 boys each were on the DAILY or INTERMITTENT regimen. Size adjusted lumbar spine BMD (LS BMAD), total body less head BMD (TBLH), by DXA and distal forearm bone densities by pQCT, GC exposure, VF assessment and ambulatory status were analysed at three time points; baseline, 1 and 2 years. At baseline, there were no differences in age, GC duration or any bone parameters. However, DAILY boys were shorter (height SDS DAILY = -1.4(0.9); INTERMITTENT = -0.8(1.0), p = 0.04) with higher BMI (BMI SDS DAILY = 1.5(0.9); INTERMITTENT = 0.8(1.0), p = 0.01). Over 2 years, DAILY boys got progressively shorter (delta height SDS DAILY = -0.9(1.1); INTERMITTENT = +0.1(0.6), p < 0.001). At their 2 year assessment, 5 DAILY and 10 INTERMITTENT boys were non-ambulant. DAILY boys had more VFs than INTERMITTENT boys (10 versus 2; χ2 p = 0.008). BMAD SDS remained unchanged between groups. TBLH and radius BMD declined significantly but the rate of loss was not different. In conclusion, there was a trend for more boys on daily GCs to remain ambulant but at the cost of more VFs, greater adiposity and markedly diminished growth. In contrast, boys on intermittent GCs had fewer vertebral fractures but there was a trend for more boys to loose independent ambulation.

journal_name

Bone

journal_title

Bone

authors

Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

doi

10.1016/j.bone.2018.07.019

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

181-186

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(18)30287-4

journal_volume

116

pub_type

杂志文章

相关文献

BONE文献大全
  • Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters.

    abstract：BACKGROUND:Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE:To determine if 6 months of protein supplementation in conjunction with a strength and conditioning training progra...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2005.10.020

    authors： Ballard TL,Specker BL,Binkley TL,Vukovich MD

    更新日期：2006-06-01 00:00:00

  • Determinants of bone gamma-carboxyglutamic acid-containing protein in plasma of healthy aging subjects.

    abstract：:The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(85)90400-4

    authors： Catherwood BD,Marcus R,Madvig P,Cheung AK

    更新日期：1985-01-01 00:00:00

  • Characterization of damage mechanisms associated with reference point indentation in human bone.

    abstract：:Measurement of bone mineral density (BMD) is the clinical gold standard in cases of compromised skeletal integrity, such as with osteoporosis. While BMD is a useful measurement to index skeletal health, it is also limited since it cannot directly assess any mechanical properties. The ability to directly assess mechani...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.01.019

    authors： Beutel BG,Kennedy OD

    更新日期：2015-06-01 00:00:00

  • Efficacy and safety of ibandronate given by intravenous injection once every 3 months.

    abstract：:Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.bone.2004.01.007

    authors： Adami S,Felsenberg D,Christiansen C,Robinson J,Lorenc RS,Mahoney P,Coutant K,Schimmer RC,Delmas PD

    更新日期：2004-05-01 00:00:00

  • Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone.

    abstract：:Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiovascular events, specific SGLT2Is have been associated with an increas...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115254

    authors： Thrailkill KM,Bunn RC,Uppuganti S,Ray P,Garrett K,Popescu I,Pennings JS,Fowlkes JL,Nyman JS

    更新日期：2020-04-01 00:00:00

  • Immobilization-induced osteolysis and recovery in neuropathic foot impairments.

    abstract：BACKGROUND:Neuropathic foot impairments treated with immobilization and off-loading result in osteolysis. In order to prescribe and optimize rehabilitation programs after immobilization we need to understand the magnitude of pedal osteolysis after immobilization and the time course for recovery. OBJECTIVE:To determine...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.09.009

    authors： Sinacore DR,Hastings MK,Bohnert KL,Strube MJ,Gutekunst DJ,Johnson JE

    更新日期：2017-12-01 00:00:00

  • An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass.

    abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.05.016

    authors： Lei SF,Wu S,Li LM,Deng FY,Xiao SM,Jiang C,Chen Y,Jiang H,Yang F,Tan LJ,Sun X,Zhu XZ,Liu MY,Liu YZ,Chen XD,Deng HW

    更新日期：2009-05-01 00:00:00

  • Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats.

    abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.01.002

    authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

    更新日期：2004-06-01 00:00:00

  • Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.

    abstract：:Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/j.bone.2015.05.016

    authors： Harvey NC,Glüer CC,Binkley N,McCloskey EV,Brandi ML,Cooper C,Kendler D,Lamy O,Laslop A,Camargos BM,Reginster JY,Rizzoli R,Kanis JA

    更新日期：2015-09-01 00:00:00

  • Relationships between marrow fat and bone turnover in ovariectomized and intact rats.

    abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(91)90011-7

    authors： Martin RB,Zissimos SL

    更新日期：1991-01-01 00:00:00

  • Adhesive capsulitis of the shoulder (frozen shoulder) produces bone loss in the affected humerus, but long-term bony recovery is good.

    abstract：:The objective of the study was to assess the short- and long-term effects of adhesive capsulitis (frozen shoulder) on the bone mineral density (BMD) of the affected extremity. BMD and clinical status of 22 patients (group A) with active-phase unilateral adhesive capsulitis and 31 patients (group B) with a previous adh...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00049-0

    authors： Leppälä J,Kannus P,Sievänen H,Järvinen M,Vuori I

    更新日期：1998-06-01 00:00:00

  • Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression.

    abstract：:Connective tissue growth factor (CTGF) has been identified as a secretory protein encoded by an immediate early gene and is a member of the CCN family. In vitro CTGF directly regulates the proliferation and differentiation of chondrocytes; however, a previous study showed that it was localized only in the hypertrophic...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2003.07.010

    authors： Fukunaga T,Yamashiro T,Oya S,Takeshita N,Takigawa M,Takano-Yamamoto T

    更新日期：2003-12-01 00:00:00

  • RUNX2 alleles associated with BMD in Scottish women; interaction of RUNX2 alleles with menopausal status and body mass index.

    abstract：:Bone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish co...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.02.004

    authors： Vaughan T,Reid DM,Morrison NA,Ralston SH

    更新日期：2004-06-01 00:00:00

  • Photo-cured hyaluronic acid-based hydrogels containing growth and differentiation factor 5 (GDF-5) for bone tissue regeneration.

    abstract：:In this study we describe the generation and influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with growth and differentiation factor 5 (GDF-5). Prior to loading GDF-5, we characterized the release profiles from these hydrogels and tested their respective cell viabili...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.11.019

    authors： Bae MS,Ohe JY,Lee JB,Heo DN,Byun W,Bae H,Kwon YD,Kwon IK

    更新日期：2014-02-01 00:00:00

  • Effects of pregnancy and lactation on bone in cynomolgus macaques: histomorphometric analysis of iliac biopsies.

    abstract：:The effects of pregnancy and lactation on bone histomorphometry have been studied extensively in rats and dogs. However, these models differ greatly in reproductive physiology compared with women. The purpose of this study was to evaluate histomorphometric changes in iliac crest bone biopsies taken from cynomolgus mon...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00032-5

    authors： Lees CJ,Jerome CP

    更新日期：1998-05-01 00:00:00

  • Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts.

    abstract：:We have previously shown that the therapeutic range of ultrasound heals osteoradionecrotic bone and induces bone formation in vitro. It is well established that nitric oxide (NO) and prostaglandins are crucial early mediators in mechanically induced bone formation. The therapeutic range of ultrasound may act in the sa...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(02)00789-5

    authors： Reher P,Harris M,Whiteman M,Hai HK,Meghji S

    更新日期：2002-07-01 00:00:00

  • Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice.

    abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.03.027

    authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

    更新日期：2019-06-01 00:00:00

  • Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia.

    abstract：:Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.06.037

    authors： Bragdon B,Thinakaran S,Moseychuk O,Gurski L,Bonor J,Price C,Wang L,Beamer WG,Nohe A

    更新日期：2011-11-01 00:00:00

  • Fracture risk reduction during treatment with teriparatide is independent of pretreatment bone turnover.

    abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.bone.2006.02.003

    authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

    更新日期：2006-08-01 00:00:00

  • Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women.

    abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2013.05.021

    authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

    更新日期：2013-09-01 00:00:00

  • Neuropeptide Y Y1 receptor antagonism increases bone mass in mice.

    abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2012.03.020

    authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

    更新日期：2012-07-01 00:00:00

  • Osteoprogenitor cells in cell populations derived from mouse and rat calvaria differ in their response to corticosterone, cortisol, and cortisone.

    abstract：:Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00084-2

    authors： Bellows CG,Ciaccia A,Heersche JN

    更新日期：1998-08-01 00:00:00

  • The limitations of using simple definitions of glucocorticoid exposure to predict fracture risk: A cohort study.

    abstract：PURPOSE:To evaluate the effects of different definitions of glucocorticoid (GC) exposure on the magnitude and pattern of fracture risk using the same dataset. METHODS:Data from patients with rheumatoid arthritis (RA) were extracted from the Clinical Practice Research Datalink, a primary care database with electronic h...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.09.004

    authors： Robinson DE,van Staa TP,Dennison EM,Cooper C,Dixon WG

    更新日期：2018-12-01 00:00:00

  • Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic.

    abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115795

    authors： Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

    更新日期：2021-03-01 00:00:00

  • Estrogen-specific action on bone geometry and volumetric bone density: longitudinal observations in an adult with complete androgen insensitivity.

    abstract：INTRODUCTION:Sex steroids have distinct effects on bone growth and maintenance in men and women, mediated through their respective steroid receptors. Though most evidence is derived from animal studies, several concepts have been confirmed in humans by detection of specific mutations. In this report we describe changes...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.04.198

    authors： Taes Y,Lapauw B,Vandewalle S,Zmierczak H,Goemaere S,Vanderschueren D,Kaufman JM,T'Sjoen G

    更新日期：2009-08-01 00:00:00

  • Lifelong risk factors for osteoporosis and fractures in elderly women with low body mass index--a population-based study.

    abstract：:Low body weight is associated with an increased risk for osteoporosis and fractures, but the contribution of other lifestyle related factors have not been previously studied within lean elderly women. The present study evaluated the association between lifelong lifestyle factors and bone density, falls and postmenopau...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.01.143

    authors： Korpelainen R,Korpelainen J,Heikkinen J,Väänänen K,Keinänen-Kiukaanniemi S

    更新日期：2006-08-01 00:00:00

  • miR300 intervenes Smad3/β-catenin/RunX2 crosstalk for therapy with an alternate function as indicative biomarker in osteoporosis.

    abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115603

    authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

    更新日期：2021-02-01 00:00:00

  • Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

    abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115513

    authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

    更新日期：2020-09-01 00:00:00

  • Crosstalk between Activin A and Shh signaling contributes to the proliferation and differentiation of antler chondrocytes.

    abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.03.036

    authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

    更新日期：2019-06-01 00:00:00

  • Increase in vertebral body size in postmenopausal women with osteoporosis.

    abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2010.03.020

    authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

    更新日期：2010-08-01 00:00:00