Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis).

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：:Bone morbidity associated with antineoplastic treatment is a significant health concern for postmenopausal breast cancer patients. Trials have demonstrated that adjuvant therapy with an Aromatase Inhibitor is associated with an increase in musculoskeletal disorders and bone fractures. The objective of this study was t...

journal_title：Bone

authors： Szabo KA,Webber CE,Adachi JD,Tozer R,Gordon C,Papaioannou A

更新日期：2011-02-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00

abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...

journal_title：Bone

authors： Hutchison C,Pilote M,Roy S

更新日期：2007-01-01 00:00:00

abstract：:Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...

journal_title：Bone

authors： van Beek E,Oostendorp-van de Ruit M,van der Wee-Pals L,Bloys H,van de Bent C,Papapoulos S,Löwik C

更新日期：1995-07-01 00:00:00

abstract：INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...

journal_title：Bone

authors： Tenne M,McGuigan F,Jansson L,Gerdhem P,Obrant KJ,Luthman H,Akesson K

更新日期：2008-04-01 00:00:00

abstract：:We performed a comprehensive analysis of the relationships between histologic indices in the iliac crest (cancellous bone volume, trabecular structural indices, cortical width, and core width) and bone density in the spine, hip, and wrist in 81 patients with various metabolic bone diseases including osteoporosis, oste...

journal_title：Bone

authors： Cosman F,Schnitzer MB,McCann PD,Parisien MV,Dempster DW,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:The long prevailing view that obesity is generally associated with beneficial effects on the skeleton has recently been challenged. Apolipoprotein E (apoE) is known to influence both adipose tissue and bone. The goal of the current study was to examine the impact of apoE on the development of fat mass and bone mass in...

journal_title：Bone

authors： Bartelt A,Beil FT,Schinke T,Roeser K,Ruether W,Heeren J,Niemeier A

更新日期：2010-10-01 00:00:00

abstract：:The multi-domain neutral endopeptidase, ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin repeats) is induced by parathyroid hormone (PTH) in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling. However, its function(s) in bone cells have not been studied. Her...

journal_title：Bone

authors： Rehn AP,Birch MA,Karlström E,Wendel M,Lind T

更新日期：2007-08-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:Active vitamin D is a major therapeutic agent for bone disease. Although some studies have reported that vitamin D ameliorates bone disease related to diabetes, the mechanism remains unclear. Our study investigated the effect of the vitamin D receptor activator 22-oxacalcitriol (OCT) on bone disease in a rat model of ...

journal_title：Bone

authors： Goto S,Fujii H,Kono K,Nakai K,Awata R,Yonekura Y,Hirata M,Shinohara M,Nishi S,Fukagawa M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Autosomal recessive osteopetrosis (ARO) is a rare congenital disorder of defective bone resorption. The inability of osteoclasts to resorb bone compromises the development of bone marrow cavity, and ultimately, leads to defective hematopoiesis and death within the first decade. The only curative treatment cur...

journal_title：Bone

authors： Maximova N,Zennaro F,Gregori M,Boz G,Zanon D,Mbalaviele G

更新日期：2020-01-01 00:00:00

abstract：:Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1(-...

journal_title：Bone

authors： Hajjawi MO,MacRae VE,Huesa C,Boyde A,Millán JL,Arnett TR,Orriss IR

更新日期：2014-12-01 00:00:00

abstract：:Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...

journal_title：Bone

authors： Bach-Gansmo FL,Brüel A,Jensen MV,Ebbesen EN,Birkedal H,Thomsen JS

更新日期：2016-10-01 00:00:00

abstract：:Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...

journal_title：Bone

authors： Hernández ER,Revilla M,Seco-Durban C,Villa LF,Cortés J,Rico H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Bone allografts carry a risk of infection, so terminal sterilization by gamma irradiation at 25kGy is recommended; but is deleterious to bone quality. Contemporary bone banking significantly reduces initial allograft bioburden, questioning the need to sterilize at 25kGy. METHODS:We inoculated allograft bone...

journal_title：Bone

authors： Nguyen H,Cassady AI,Bennett MB,Gineyts E,Wu A,Morgan DA,Forwood MR

更新日期：2013-11-01 00:00:00

abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...

journal_title：Bone

authors： Takahashi K,Tsuboyama T,Matsushita M,Kasai R,Okumura H,Yamamuro T,Okamoto Y,Kitagawa K,Takeda T

更新日期：1994-03-01 00:00:00

abstract：:Spinal cord injury (SCI) results in a dramatic loss of bone mineral and a marked increase in fracture incidence in the femur; however, its effect on the femur's geometric structure and strength is poorly studied. The primary purpose of the present study was to assess the geometric structure, composition, and strength ...

journal_title：Bone

authors： Modlesky CM,Slade JM,Bickel CS,Meyer RA,Dudley GA

更新日期：2005-02-01 00:00:00

abstract：:The accumulation of microdamage in bone may contribute to loss of bone quality in osteoporosis, and the role of microdamage in the etiology of fatigue fractures is unknown. Microdamage created during testing, ex vivo, can increase the fragility of bone by decreasing the load necessary to cause fracture. Microdamage ca...

journal_title：Bone

authors： Fazzalari NL,Forwood MR,Manthey BA,Smith K,Kolesik P

更新日期：1998-10-01 00:00:00

abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...

journal_title：Bone

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2019-06-01 00:00:00

abstract：:The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear. The aim of this study was to assess the effect of low dose vitamin D supplementation during pregnancy on bony anthropometric aspects of the fetus. In this prospective randomized trial, 140 patients were divided into two equal...

journal_title：Bone

authors： Vafaei H,Asadi N,Kasraeian M,Shahraki HR,Bazrafshan K,Namazi N

更新日期：2019-05-01 00:00:00

abstract：:Popular psychotropic drugs, like the antidepressant selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), and the mood stabilizer lithium, may have skeletal effects. In particular, preclinical observations suggest a direct negative effect of SSRIs on the skeleton. A potential caveat in ...

journal_title：Bone

authors： Warden SJ,Hassett SM,Bond JL,Rydberg J,Grogg JD,Hilles EL,Bogenschutz ED,Smith HD,Fuchs RK,Bliziotes MM,Turner CH

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ossification processes. Alterations in transforming growth factor β (TGFβ) s...

journal_title：Bone

authors： de Kroon LMG,van den Akker GGH,Brachvogel B,Narcisi R,Belluoccio D,Jenner F,Bateman JF,Little CB,Brama PAJ,Blaney Davidson EN,van der Kraan PM,van Osch GJVM

更新日期：2018-11-01 00:00:00

abstract：:Chronic alcohol abuse is a risk factor for osteoporosis in men. Human recombinant parathyroid hormone (1-34) (PTH) therapy increases bone mass in patients with osteoporosis. The purpose of the present study was to determine whether PTH is effective in increasing bone formation and bone mass in a rat model for establis...

journal_title：Bone

authors： Sibonga JD,Iwaniec UT,Shogren KL,Rosen CJ,Turner RT

更新日期：2007-04-01 00:00:00

abstract：:An emerging strategy in the regeneration and repair of bone is to use stem cells, including bone marrow mesenchymal stem cells, which are the most investigated and reliable source for tissue engineering, as well as circulating skeletal stem/progenitor cells, which are receiving abundant attention in regenerative medic...

journal_title：Bone

authors： Matsumoto T,Kuroda R,Mifune Y,Kawamoto A,Shoji T,Miwa M,Asahara T,Kurosaka M

更新日期：2008-09-01 00:00:00

abstract：:In the development of 3-dimensional cell-polymer matrices for tissue engineering, the ability of osteoblast cells to maintain their phenotypic properties and form a mineralized matrix while seeded on the polymer surface is very important. Osteoblast cell differentiation and bone formation using rat calvaria cells were...

journal_title：Bone

authors： Laurencin CT,Attawia MA,Elgendy HE,Herbert KM

更新日期：1996-07-01 00:00:00

abstract：:The metabolic fate of whole grafts that were either vascularized or nonvascularized were compared. This study was designed to quantify and correlate changes in bone resorption, formation, and mass in orthotopic, stably fixed, weight-bearing autografts. The grafts were 8-cm segments of the fibula that were internally f...

journal_title：Bone

authors： Klein L,Stevenson S,Shaffer JW,Davy D,Goldberg VM

更新日期：1991-01-01 00:00:00

abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

journal_title：Bone

authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

更新日期：2012-03-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Specific physical loading leads to enhanced bone development during childhood. A general physical activity program mimicking a real-life situation was successful at increasing general physical health in children. Yet, it is not clear whether it can equally increase bone mineral mass. We performed a cluster-r...

journal_title：Bone

authors： Meyer U,Romann M,Zahner L,Schindler C,Puder JJ,Kraenzlin M,Rizzoli R,Kriemler S

更新日期：2011-04-01 00:00:00