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Relationships among ultrasonic and mechanical properties of cancellous bone in human calcaneus in vitro.

Abstract：

:Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical properties in 25 human calcaneal cancellous bone specimens (approximately 2×4×2cm). Normalized broadband ultrasound attenuation, speed of sound, and broadband ultrasound backscatter were measured with 500kHz transducers. To assess mechanical properties, non-linear finite element analysis, based on micro-computed tomography images (34-micron cubic voxel), was used to estimate apparent elastic modulus, overall specimen stiffness, and apparent yield stress, with models typically having approximately 25-30 million elements. We found that ultrasound parameters were correlated with mechanical properties with R=0.70-0.82 (p<0.001). Multiple regression analysis indicated that ultrasound measurements provide additional information regarding mechanical properties beyond that provided by bone quantity alone (p≤0.05). Adding ultrasound variables to linear regression models based on bone quantity improved adjusted squared correlation coefficients from 0.65 to 0.77 (stiffness), 0.76 to 0.81 (apparent modulus), and 0.67 to 0.73 (yield stress). These results indicate that ultrasound can provide complementary (to bone quantity) information regarding mechanical behavior of cancellous bone.

journal_name

Bone

journal_title

Bone

authors

Wear KA,Nagaraja S,Dreher ML,Sadoughi S,Zhu S,Keaveny TM

doi

10.1016/j.bone.2017.06.021

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

93-101

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(17)30220-X

journal_volume

103

pub_type

杂志文章

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