The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

abstract：:We have recently cloned cathepsin K from a human bone cDNA library. Since cathepsins are proposed to be involved in the degradation of mineralized bone matrix, we have investigated, by in situ hybridization and immunocytochemistry, the expression of the cathepsin K mRNA transcripts and protein in sections of bone and ...

journal_title：Bone

authors： Littlewood-Evans A,Kokubo T,Ishibashi O,Inaoka T,Wlodarski B,Gallagher JA,Bilbe G

更新日期：1997-02-01 00:00:00

abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

journal_title：Bone

authors： Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

更新日期：2005-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can self-renew and differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. It's reported that bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic BMPs to initiate the commitment of MSCs to osteoblast lineage. Cyclooxygenase-2 (COX-2) is critical...

journal_title：Bone

authors： Wang JH,Liu YZ,Yin LJ,Chen L,Huang J,Liu Y,Zhang RX,Zhou LY,Yang QJ,Luo JY,Zuo GW,Deng ZL,He BC

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Bone scintigraphy used as a diagnostic technique frequently yields non-specific intense uptake by vertebrae. Bone biopsy may therefore be required to establish a diagnosis in cases of Paget's disease of bone. The aim of the study was to ascertain the sensitivity and specificity of two new images-heart sign a...

journal_title：Bone

authors： Rotés-Sala D,Monfort J,Solano A,Miralles E,Vila J,Carbonell J

更新日期：2004-04-01 00:00:00

abstract：CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...

journal_title：Bone

authors： Feuer AJ,Demmer RT,Thai A,Vogiatzi MG

更新日期：2015-09-01 00:00:00

abstract：:A stabilized tibia fracture model was used in young (8-week old) and aged (1-year old) mice to define the relative bone regenerative potential and the relative responsiveness of the periosteal progenitor population with aging and PTH 1-34 (PTH) systemic therapy. Bone regeneration was assessed through gene expressions,...

journal_title：Bone

authors： Yukata K,Xie C,Li TF,Takahata M,Hoak D,Kondabolu S,Zhang X,Awad HA,Schwarz EM,Beck CA,Jonason JH,O'Keefe RJ

更新日期：2014-05-01 00:00:00

abstract：:We described a chick periosteal osteogenesis model at the light microscopic level and biochemically. To confirm that morphologically identifiable bone is being formed, we performed an ultrastructural study of this model. Samples of freshly dissected periostea, as well as whole calvariae, were fixed in glutaraldehyde. ...

journal_title：Bone

authors： Tenenbaum HC,Palangio KG,Holmyard DP,Pritzker KP

更新日期：1986-01-01 00:00:00

abstract：:Bone mineral "density" (BMD) measured by dual-energy X-ray absorptiometry (DEXA) does not represent the volumetric density (grams per cubic centimeter), but rather the areal density (grams per square centimeter). This distinction is important during growth. The purpose of this study was to measure vertebral dimensions...

journal_title：Bone

authors： Ott SM,O'Hanlan M,Lipkin EW,Newell-Morris L

更新日期：1997-06-01 00:00:00

abstract：:Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...

journal_title：Bone

authors： Chen L,Li D,Li C,Engel A,Deng CX

更新日期：2003-08-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) has been identified as a secretory protein encoded by an immediate early gene and is a member of the CCN family. In vitro CTGF directly regulates the proliferation and differentiation of chondrocytes; however, a previous study showed that it was localized only in the hypertrophic...

journal_title：Bone

authors： Fukunaga T,Yamashiro T,Oya S,Takeshita N,Takigawa M,Takano-Yamamoto T

更新日期：2003-12-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

journal_title：Bone

authors： Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

更新日期：2020-08-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...

journal_title：Bone

authors： Haynes DR,Atkins GJ,Loric M,Crotti TN,Geary SM,Findlay DM

更新日期：1999-09-01 00:00:00

abstract：:The role of vitamin D receptor (VDR) gene polymorphisms in the determination of bone mass and bone turnover is controversial in women. The aim of the study was to determine whether VDR polymorphisms are associated with indices of bone mineral density (BMD) (by dual-energy X-ray absorptiometry and by ultrasound) and/or...

journal_title：Bone

authors： Van Pottelbergh I,Goemaere S,De Bacquer D,De Paepe A,Kaufman M

更新日期：2002-11-01 00:00:00

abstract：:Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery...

journal_title：Bone

authors： Sternheim A,Giladi O,Gortzak Y,Drexler M,Salai M,Trabelsi N,Milgrom C,Yosibash Z

更新日期：2018-05-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：:Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant dec...

journal_title：Bone

authors： Pfeilschifter J,Minne HW,Enzmann E,Krempien B,Ziegler R

更新日期：1985-01-01 00:00:00

abstract：:Bone can be viewed as a nano-fibrous composite with complex hierarchical structures. Its deformation and fracture behaviors depend on both the local structure and the type of stress applied. In contrast to the extensive studies on bone fracture under compression and tension, there is a lack of knowledge on the fractur...

journal_title：Bone

authors： Tang T,Ebacher V,Cripton P,Guy P,McKay H,Wang R

更新日期：2015-02-01 00:00:00

abstract：:Osteocyte canalicular density (OCD) was evaluated at different levels of the wall of human secondary osteons, in subjects of different ages, to find out whether any correlation exists between the extension of the canalicular network and the exponential decrement of the appositional growth rate (AGR), which has been sh...

journal_title：Bone

authors： Marotti G,Ferretti M,Remaggi F,Palumbo C

更新日期：1995-01-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) isolated from extracted third molar ...

journal_title：Bone

authors： Tóth F,Gáll JM,Tőzsér J,Hegedűs C

更新日期：2020-03-01 00:00:00

abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...

journal_title：Bone

authors： Dennison EM,Jameson KA,Edwards MH,Denison HJ,Aihie Sayer A,Cooper C

更新日期：2014-07-01 00:00:00

abstract：:Avian tibial dyschondroplasia is a disorder of endochondral ossification which results in the accumulation of noncalcified, avascular cartilage. We have investigated the changes in cell proliferation and enzyme activities within specific cell types in the growth plate of chickens with differing severity of the disease...

journal_title：Bone

authors： Farquharson C,Whitehead C,Rennie S,Thorp B,Loveridge N

更新日期：1992-01-01 00:00:00

abstract：:Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...

journal_title：Bone

authors： Rantalainen T,Sievänen H,Linnamo V,Hoffrén M,Ishikawa M,Kyröläinen H,Avela J,Selänne H,Komi PV,Heinonen A

更新日期：2009-11-01 00:00:00

abstract：:Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...

journal_title：Bone

authors： Dubin RL,Hall CM,Pileri CL,Kudlacek PE,Li XY,Yee JA,Johnson ML,Anderson RJ

更新日期：2001-06-01 00:00:00

abstract：:Three distinct osteoblastic cell lines (KS418, KS460, and KS483) were subcloned from the mouse osteoblastic KS-4 cells, which possessed the abilities not only to differentiate into mature osteoblasts, but also to support osteoclast differentiation in coculture with spleen cells. The order of the magnitude of the basal...

journal_title：Bone

authors： Yamashita T,Ishii H,Shimoda K,Sampath TK,Katagiri T,Wada M,Osawa T,Suda T

更新日期：1996-11-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...

journal_title：Bone

authors： Imel EA,Liu Z,McQueen AK,Acton D,Acton A,Padgett LR,Peacock M,Econs MJ

更新日期：2016-05-01 00:00:00

abstract：:It is now well established that important regulatory interactions occur between the cells in the hematopoietic, immune and skeletal systems (osteoimmunology). B lymphocytes (B cells) are responsible for the generation and production of antibodies or immunoglobulins in the body. Together with T cells these lymphocytes ...

journal_title：Bone

authors： Horowitz MC,Fretz JA,Lorenzo JA

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). ...

journal_title：Bone

authors： Zhang Q,Greenbaum J,Zhang WD,Sun CQ,Deng HW

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...

journal_title：Bone

authors： Chaudhary R,Lee MS,Mubyana K,Duenwald-Kuehl S,Johnson L,Kaiser J,Vanderby R Jr,Eliceiri KW,Corr DT,Chin MS,Li WJ,Campagnola PJ,Halanski MA

更新日期：2016-11-01 00:00:00

abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...

journal_title：Bone

authors： Sasaki T,Watanabe C

更新日期：1995-01-01 00:00:00