Abstract:
:Twenty patients with mild Paget's disease of bone were given either 20 (10 patients) or 40 mg alendronate daily for 6 months. The 20-mg dose was well tolerated, but in 3 patients on 40 mg/d alendronate, the treatment was withdrawn after 3-5 months because of gastric and oesophageal disturbances. Urinary hydroxyproline excretion fell within the first month to 77 +/- 5% (SD) and to 47 +/- 5% of pretreatment values in the 20- and 40-mg dosing group, respectively (p < 0.001 between group comparison). The serum alkaline phosphatase fell more slowly with the maximum suppression of disease activity reached at 4 months, when it attained a plateau in both groups of patients. However, the decrease in serum alkaline phosphatase was significantly more pronounced in the patients treated with 40 mg/d tablets (50 +/- 10% of pretreatment values) than in those given 20 mg alendronate per day (76 +/- 9% of initial value), in none of whom a disease remission was observed. It appears, therefore, that while 20 mg/d oral doses of alendronate are insufficient, 40 mg/d are associated with a high incidence of side effects. Furthermore, the suppression of disease activity depends on the dose of bisphosphonate given daily or over a short period of time and lower doses cannot be compensated by a longer duration of the treatment course.
journal_name
Bonejournal_title
Boneauthors
Adami S,Mian M,Gatti P,Rossini M,Zamberlan N,Bertoldo F,Lo Cascio Vdoi
10.1016/8756-3282(94)90818-4subject
Has Abstractpub_date
1994-07-01 00:00:00pages
415-7issue
4eissn
8756-3282issn
1873-2763pii
8756-3282(94)90818-4journal_volume
15pub_type
临床试验,杂志文章相关文献
BONE文献大全abstract::Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.026
更新日期:2019-06-01 00:00:00
abstract::In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cell...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00660-3
更新日期:2002-01-01 00:00:00
abstract::Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00135-z
更新日期:1995-07-01 00:00:00
abstract::Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.041
更新日期:2013-05-01 00:00:00
abstract::In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.012
更新日期:2016-11-01 00:00:00
abstract::The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00194-i
更新日期:1995-08-01 00:00:00
abstract::Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also biochemical factors. Adiponectin is a novel adipocyte-derived hormone that regulates energy homeostasis and has anti-inflammatory and anti-atherogenic effects. Unlik...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00237-0
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.022
更新日期:2014-09-01 00:00:00
abstract::The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00855-4
更新日期:2002-10-01 00:00:00
abstract::Bone homeostasis is regulated by a balance of bone formation and bone resorption; dysregulation of bone homeostasis may cause bone-related diseases (e.g., osteoporosis, osteopetrosis, bone fracture). Members of the nuclear factor of activated T cells (NFAT) family of transcription factors play crucial roles in the reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115153
更新日期:2020-02-01 00:00:00
abstract::Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.10.026
更新日期:2019-03-01 00:00:00
abstract::Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.12.002
更新日期:2007-04-01 00:00:00
abstract::Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bon...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.02.006
更新日期:2005-05-01 00:00:00
abstract::The aim of this study was to estimate the burden of childhood rickets-like bone deformity in a rural region of West Africa where rickets has been reported in association with a low calcium intake. A population-based survey of children aged 0.5-17.9 years living in the province of West Kiang, The Gambia was conducted i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.011
更新日期:2015-08-01 00:00:00
abstract::Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.008
更新日期:2018-12-01 00:00:00
abstract::Combat-related heterotopic ossification (HO) has emerged as a common and problematic complication of modern wartime extremity injuries, contributing to substantial patient morbidity and loss of function. We have previously reported that HO-forming patients exhibit a more pronounced systemic and local inflammatory resp...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.05.016
更新日期:2013-09-01 00:00:00
abstract::It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00180-l
更新日期:1995-08-01 00:00:00
abstract::Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00176-3
更新日期:1999-09-01 00:00:00
abstract::High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS D...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2012.10.021
更新日期:2013-01-01 00:00:00
abstract::The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90400-4
更新日期:1985-01-01 00:00:00
abstract::Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.015
更新日期:2013-10-01 00:00:00
abstract::We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.06.008
更新日期:2011-10-01 00:00:00
abstract::Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores small...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.013
更新日期:2019-06-01 00:00:00
abstract::Over 60% of our severely combat-injured patient population develops radiographically apparent heterotopic ossification. Nearly a third of these require surgical excision of symptomatic lesions, a procedure that is fraught with complications, and delays or regresses functional rehabilitation in many cases. Unfortunatel...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.08.026
更新日期:2013-12-01 00:00:00
abstract::Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(03)00112-1
更新日期:2003-09-01 00:00:00
abstract::We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00287-n
更新日期:1995-10-01 00:00:00
abstract::New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.05.021
更新日期:2008-10-01 00:00:00
abstract::The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00280-3
更新日期:1996-12-01 00:00:00
abstract::This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00274-x
更新日期:2000-06-01 00:00:00