Role of cytokines in bone resorption.

abstract：PURPOSE:Diabetes and osteoporosis occur frequently in older adults and are both associated with increased fracture risk. Denosumab treatment reduced new vertebral, nonvertebral, and hip fractures over 3 years, with continued low fracture incidence for up to 10 years in postmenopausal women with osteoporosis. However, i...

journal_title：Bone

authors： Ferrari S,Eastell R,Napoli N,Schwartz A,Hofbauer LC,Chines A,Wang A,Pannacciulli N,Cummings SR

更新日期：2020-05-01 00:00:00

abstract：:A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...

journal_title：Bone

authors： Kwun IS,Cho YE,Lomeda RA,Shin HI,Choi JY,Kang YH,Beattie JH

更新日期：2010-03-01 00:00:00

abstract：:Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...

journal_title：Bone

authors： Iwasaki Y,Kazama JJ,Yamato H,Fukagawa M

更新日期：2011-06-01 00:00:00

abstract：:To determine osteocalcin (OC) and adipokines in type 1 diabetes (T1D) and healthy controls, and to explore possible associations between glucose and bone metabolism, body composition and adipokines. Serum levels of total OC, undercarboxylated (UC-OC), leptin, adiponectin, and other parameters of glucose and bone metab...

journal_title：Bone

authors： Neumann T,Lodes S,Kästner B,Franke S,Kiehntopf M,Lehmann T,Müller UA,Wolf G,Sämann A

更新日期：2016-01-01 00:00:00

abstract：:Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration, a requirement of long-term orthopedic implant stability. Clinically, the amount of bone ingrowth is variable, and cellular parameters that influence ingrowth have yet to be cle...

journal_title：Bone

authors： Shah AK,Sinha RK,Hickok NJ,Tuan RS

更新日期：1999-05-01 00:00:00

abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...

journal_title：Bone

authors： Hutchison C,Pilote M,Roy S

更新日期：2007-01-01 00:00:00

abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

journal_title：Bone

authors： Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

更新日期：2005-03-01 00:00:00

abstract：:The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...

journal_title：Bone

authors： Wergedal JE,Sheng MH,Ackert-Bicknell CL,Beamer WG,Baylink DJ

更新日期：2002-12-01 00:00:00

abstract：:Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...

journal_title：Bone

authors： Guay-Bélanger S,Simonyan D,Bureau A,Gagnon E,Albert C,Morissette J,Siris ES,Orcel P,Brown JP,Michou L

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...

journal_title：Bone

authors： Yan L,Prentice A,Zhou B,Zhang H,Wang X,Stirling DM,Laidlaw A,Han Y,Laskey A

更新日期：2002-02-01 00:00:00

abstract：:Several studies have documented that diabetes impairs bone healing clinically and experimentally. Systemic insulin treatment has been shown to ameliorate impaired diabetic bone healing. However, these studies failed to distinguish between a direct and a systemic effect of insulin upon bone healing. A novel intramedull...

journal_title：Bone

authors： Gandhi A,Beam HA,O'Connor JP,Parsons JR,Lin SS

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Preterm infants are at risk for impaired bone mineralization and growth in length later in life due to inadequate nutritional intake in the early postnatal period. OBJECTIVE:To investigate whether increased nutritional supplementation of calcium, phosphate and protein in Very Low Birth Weight (VLBW) infants...

journal_title：Bone

authors： Christmann V,van der Putten ME,Rodwell L,Steiner K,Gotthardt M,van Goudoever JB,van Heijst AFJ

更新日期：2018-03-01 00:00:00

abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...

journal_title：Bone

authors： Lepola V,Jalovaara P,Väänänen K

更新日期：1994-05-01 00:00:00

abstract：:The potency of magnetic resonance imaging (MRI) to measure the exact extent of osteonecrosis of the femoral head (ONFH) remains uncertain. The objective of this study was to determine if the volume of necrosis assessed with MRI accurately reflects the volume of architectural mineral alterations in osteonecrosis of the...

journal_title：Bone

authors： Pascart T,Paccou J,Colard T,Norberciak L,Girard J,Delattre J,Marchandise P,Legrand J,Penel G,Coursier R,Putman S,Cortet B,Kerckhofs G,Budzik JF

更新日期：2020-01-01 00:00:00

abstract：:The role of drinking water fluoride content for prevention of osteoporosis remains controversial. Therefore, we analyzed the influence of drinking water fluoridation on the incidence of osteoporotic hip fractures and bone mineral density (BMD) in two different communities in eastern Germany: in Chemnitz, drinking wate...

journal_title：Bone

authors： Lehmann R,Wapniarz M,Hofmann B,Pieper B,Haubitz I,Allolio B

更新日期：1998-03-01 00:00:00

abstract：:Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...

journal_title：Bone

authors： Maulding ND,Kavanagh D,Zimmerman K,Coppola G,Carpenter TO,Jue NK,Braddock DT

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

journal_title：Bone

authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

更新日期：2018-07-01 00:00:00

abstract：:The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...

journal_title：Bone

authors： Kanis JA

更新日期：1995-08-01 00:00:00

abstract：:A macro-micro-nano-multi-level study was conducted to explore age-related structural and mechanical properties of bone, as well as the effects of aging on bone properties. A total of 70 male Wistar rats were used, ranging in the ages of 1, 3, 5, 7, 9, 11, 14, 15, 16, and 17 months (n = 7/age group). After micro-comput...

journal_title：Bone

authors： Zhang R,Gong H,Zhu D,Ma R,Fang J,Fan Y

更新日期：2015-07-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a progressive muscle disorder caused by genetic mutations of the dystrophin encoding gene. In the absence of functional dystrophin, DMD patients suffer from muscle inflammation and wasting, as well as compromised bone health with increased risk of fracture. The use of high dose glu...

journal_title：Bone

authors： Yoon SH,Grynpas M,Mitchell J

更新日期：2019-04-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：:Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...

journal_title：Bone

authors： Lynn H,Kwok T,Wong SY,Woo J,Leung PC

更新日期：2006-04-01 00:00:00

abstract：:Localized proton spectra of the human lumbar vertebral body were recorded in vivo at 1.5 T, using the STEAM (stimulated echo acquisition mode) pulse sequence. Thirty-seven patients (18 men, 19 women) were examined, ranging in age from 21 to 68 years (mean = 40, SD = 13). The fat fraction of the bone marrow was calcula...

journal_title：Bone

authors： De Bisschop E,Luypaert R,Louis O,Osteaux M

更新日期：1993-03-01 00:00:00

abstract：:ED-71, a novel analog of 1alpha,25-(OH)2 D3, increases bone mass to a greater extent than alfacalcidol, an 1alpha,25-(OH)2 D3 prodrug. In this study, we used a murine bone marrow ablation model to compare the effect of ED-71 on bone formation and resorption in vivo with that of 1alpha,25-(OH)2 D3. We discovered that b...

journal_title：Bone

authors： Okuda N,Takeda S,Shinomiya K,Muneta T,Itoh S,Noda M,Asou Y

更新日期：2007-02-01 00:00:00

abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

journal_title：Bone

authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

更新日期：1990-01-01 00:00:00

abstract：:Pregnancy is a common physiological event that could affect peak bone mass and the risk of developing osteoporosis later in life. There have been few longitudinal studies over a complete reproductive cycle of any size to show whether bone mineral density (BMD) changes. We have measured BMD by dual-energy X-ray absorpt...

journal_title：Bone

authors： Kaur M,Pearson D,Godber I,Lawson N,Baker P,Hosking D

更新日期：2003-04-01 00:00:00

abstract：:The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...

journal_title：Bone

authors： Aoyagi M,Sasaki T,Ramamurthy NS,Golub LM

更新日期：1996-12-01 00:00:00

abstract：:Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical propertie...

journal_title：Bone

authors： Wear KA,Nagaraja S,Dreher ML,Sadoughi S,Zhu S,Keaveny TM

更新日期：2017-10-01 00:00:00

abstract：:Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metab...

journal_title：Bone

authors： China SP,Pal S,Chattopadhyay S,Porwal K,Kushwaha S,Bhattacharyya S,Mittal M,Gurjar AA,Barbhuyan T,Singh AK,Trivedi AK,Gayen JR,Sanyal S,Chattopadhyay N

更新日期：2017-12-01 00:00:00