Abstract:
:Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metabolism under the setting of post-menopausal (estrogen-deficiency) osteopenia and associated metabolic derangements has not been studied. Here, we studied the therapeutic effect of the globular form of adiponectin (gAd), which is predominantly an adipoR1 agonist, in aged ovariectomized (OVX) rats and compared it with standard-of-care anti-osteoporosis drugs. In OVX rats with established osteopenia, gAd completely restored BMD and load bearing capacity and improved bone quality. Skeletal effects of gAd were comparable to PTH (osteoanabolic) but better than alendronate (anti-catabolic). Both osteoanabolic and anti-catabolic mechanisms led to the anti-osteoporosis effect of gAd. In cultured osteoblasts and bones, gAd increased a) adipoR1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression to promote mitochondrial respiration, which likely fueled osteoblast differentiation, b) suppressed sclerostin (a wnt antagonist) in a sirtuin1-dependent manner and c) decreased receptor-activator of nuclear factor κB ligand (RANKL) to achieve its anti-catabolic effect. The OVX-induced sarcopenia and insulin resistance were also improved by gAd. We conclude that gAd has therapeutic efficacy in estrogen deficiency-induced osteoporosis, sarcopenia and insulin resistance and hold metabolic disease modifying potential in postmenopausal women.
journal_name
Bonejournal_title
Boneauthors
China SP,Pal S,Chattopadhyay S,Porwal K,Kushwaha S,Bhattacharyya S,Mittal M,Gurjar AA,Barbhuyan T,Singh AK,Trivedi AK,Gayen JR,Sanyal S,Chattopadhyay Ndoi
10.1016/j.bone.2017.08.005subject
Has Abstractpub_date
2017-12-01 00:00:00pages
75-86eissn
8756-3282issn
1873-2763pii
S8756-3282(17)30287-9journal_volume
105pub_type
杂志文章相关文献
BONE文献大全abstract::The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115324
更新日期:2020-06-01 00:00:00
abstract::Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and "life-style" factors may modulate the skeletal response to PTH. Alcohol may represent one of these factors. Chronic alcohol abuse is ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.12.221
更新日期:2008-04-01 00:00:00
abstract::A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(96)00077-4
更新日期:1996-06-01 00:00:00
abstract::In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.025
更新日期:2010-05-01 00:00:00
abstract::A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of postmenopausal osteoporosis. We have utilized the ovariohysterectomized (Ovh) dog to examine cellular and biochemical responses to estrogen depletion and PTH stim...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90075-8
更新日期:1992-01-01 00:00:00
abstract::One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.017
更新日期:2011-05-01 00:00:00
abstract::Osteonecrosis of the femoral head (ONFH) is a skeletal disorder characterized by ischemic deterioration, bone marrow edema and eventually femoral head collapse. The systemic regulation of ONFH in adult patients has not been examined. Serum proteomic is an innovative tool that potentially detects simultaneous expressio...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.04.019
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:High plasma homocysteine (Hcy) levels have been associated with increased risk of fracture. Since Hcy has been shown to induce apoptosis in many cell types, including vascular endothelial cells, we hypothesized that Hcy would have a similar apoptotic effect on osteoblasts, leading to osteoporosis by reduci...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.03.004
更新日期:2006-09-01 00:00:00
abstract::Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.001
更新日期:2015-05-01 00:00:00
abstract::This study is designed to test how intermittent application of prostaglandin E2 (PGE2) and risedronate (Ris) alone or in combination acts on the cancellous bone mass in estrogen-deficient rats. Sprague-Dawley rats were ovariectomized (ovx) or sham-ovx'd at 6 months of age. PGE2 (6mg/kg/d), Ris (5 micrograms/kg/twice a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00305-w
更新日期:1995-10-01 00:00:00
abstract::Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...
journal_title:Bone
pub_type: 杂志文章,meta分析
doi:10.1016/j.bone.2008.05.012
更新日期:2008-09-01 00:00:00
abstract::Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.03.672
更新日期:2011-06-01 00:00:00
abstract::Immunosuppressant drugs are currently required by transplant recipients for the remainder of their lives, despite the many adverse effects associated with these therapies. Acute osteoporosis is one such effect, and a reproducible osteoporosis model has been established through the administration of the immunosuppressa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.05.003
更新日期:2004-03-01 00:00:00
abstract::Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/8756-3282(96)88871-5
更新日期:1996-08-01 00:00:00
abstract:INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.06.001
更新日期:2007-10-01 00:00:00
abstract::Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.07.014
更新日期:2009-11-01 00:00:00
abstract::Pre-clinical in vivo models of multiple myeloma are essential tools for investigating the pathophysiology of multiple myeloma and for testing new therapeutic agents and strategies prior to their potential use in clinical trials. Over the last five decades, several different types of murine models of multiple myeloma h...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.04.004
更新日期:2015-08-01 00:00:00
abstract::Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00222-9
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Preterm infants are at risk for impaired bone mineralization and growth in length later in life due to inadequate nutritional intake in the early postnatal period. OBJECTIVE:To investigate whether increased nutritional supplementation of calcium, phosphate and protein in Very Low Birth Weight (VLBW) infants...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.12.022
更新日期:2018-03-01 00:00:00
abstract::If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injectio...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.10.016
更新日期:2010-01-01 00:00:00
abstract::General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2006.10.024
更新日期:2007-04-01 00:00:00
abstract::The deformation mechanism of bone at different hierarchical levels has been of wide interest. The important features of bone, its anisotropy and orientation dependent deformation are equally important, which have also gained a long run discussion. Most of the studies are concentrated on protein-rich collagen fibres an...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.394
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115184
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...
journal_title:Bone
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.bone.2008.11.001
更新日期:2009-03-01 00:00:00
abstract::The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115603
更新日期:2021-02-01 00:00:00
abstract::A stabilized tibia fracture model was used in young (8-week old) and aged (1-year old) mice to define the relative bone regenerative potential and the relative responsiveness of the periosteal progenitor population with aging and PTH 1-34 (PTH) systemic therapy. Bone regeneration was assessed through gene expressions,...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.02.002
更新日期:2014-05-01 00:00:00
abstract::Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00135-z
更新日期:1995-07-01 00:00:00
abstract::The objective of the study was to assess the short- and long-term effects of adhesive capsulitis (frozen shoulder) on the bone mineral density (BMD) of the affected extremity. BMD and clinical status of 22 patients (group A) with active-phase unilateral adhesive capsulitis and 31 patients (group B) with a previous adh...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00049-0
更新日期:1998-06-01 00:00:00
abstract::Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.12.008
更新日期:2010-04-01 00:00:00
abstract::Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between diet...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.020
更新日期:2011-05-01 00:00:00