Deformation of mineral crystals in cortical bone depending on structural anisotropy.

Abstract:

:The deformation mechanism of bone at different hierarchical levels has been of wide interest. The important features of bone, its anisotropy and orientation dependent deformation are equally important, which have also gained a long run discussion. Most of the studies are concentrated on protein-rich collagen fibres and matrix, where different deformation mechanisms at the lower length scales are proposed. But in relation to this, how the mineral particles behave depending on their distribution is yet to be revealed in detail. In the present work, we demonstrate mineral crystals deformation and arrangement characteristics on the basis of experimental outcomes. Using X-ray diffraction procedures, we quantified the mineral strains, degree of orientation of the crystallites and their evolution under different applied step-loads in bovine femoral cortical specimens having different alignment with the femoral axis direction. We provide a direct quantitative comparison of these parameters in the specimens having preferential orientations roughly at 0, 30, 45, 75 and 90 degrees with reference to the loading direction. The mineral strains in the compliant specimens, i.e. 0 and 30 degrees oriented specimens were observed to differ with the stiffer specimens, i.e. 75 and 90 degrees oriented specimens, whereas the 45 degrees oriented specimen show almost equal strains at different loads. These were explained by the degree of orientation with reference to the loading direction and the preferential orientation direction of the specimens. On the basis of observed parameters, we describe deformation phenomena of mineral particles to occur in different stages, which consist of redistribution stage, elastic strain stage and inelastic strain stage. These phenomena are expected to occur at different scales and rates depending on the orientation and distribution of crystals.

journal_name

Bone

journal_title

Bone

authors

Giri B,Tadano S,Fujisaki K,Sasaki N

doi

10.1016/j.bone.2009.01.394

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1111-20

issue

6

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(09)00419-0

journal_volume

44

pub_type

杂志文章

相关文献

BONE文献大全
  • Repair of a segmental long bone defect in human by implantation of a novel multiple disc graft.

    abstract::Large segmental defects of the weight bearing long bones are very difficult to reconstruct. Current treatment options are afflicted with several limitations and disadvantages. We describe a novel approach to regenerate a segmental long bone defect in a patient using a multiple disc graft. Decellularized bovine trabecu...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2010.02.011

    authors: Hesse E,Kluge G,Atfi A,Correa D,Haasper C,Berding G,Shin HO,Viering J,Länger F,Vogt PM,Krettek C,Jagodzinski M

    更新日期:2010-05-01 00:00:00

  • The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice.

    abstract::We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2011.06.008

    authors: Holmes G,Bromage TG,Basilico C

    更新日期:2011-10-01 00:00:00

  • Ornithine alpha-ketoglutarate increases mineralization and mechanical properties of tibia in turkeys.

    abstract::Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2005.12.016

    authors: Tatara MR,Sliwa E,Krupski W,Brodzki A,Pasternak K

    更新日期:2006-07-01 00:00:00

  • Prolonged alendronate treatment prevents the decline in serum TGF-β1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model.

    abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2012.10.017

    authors: Jia J,Yao W,Amugongo S,Shahnazari M,Dai W,Lay YA,Olvera D,Zimmermann EA,Ritchie RO,Li CS,Alliston T,Lane NE

    更新日期:2013-01-01 00:00:00

  • Effect of phosphodiesterase inhibitor-4, rolipram, on new bone formations by recombinant human bone morphogenetic protein-2.

    abstract::Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(02)00681-6

    authors: Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

    更新日期:2002-04-01 00:00:00

  • Histomorphometric evaluation of the influence of the diabetic metabolic state on bone defect healing depending on the defect size in spontaneously diabetic BB/OK rats.

    abstract::Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2004.03.011

    authors: Follak N,Klöting I,Wolf E,Merk H

    更新日期:2004-07-01 00:00:00

  • Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system.

    abstract::Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2020.115328

    authors: Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

    更新日期:2020-08-01 00:00:00

  • Atypical incomplete femoral fractures in asymptomatic patients on long term bisphosphonate therapy.

    abstract:OBJECTIVES:Progression of an incomplete atypical femoral fracture (IF) to a complete fracture in patients on long term bisphosphonate (BP) therapy can be catastrophic. We aimed to determine the frequency and imaging features of IF in asymptomatic patients on long-term BP therapy and to identify distinguishing clinical ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2013.03.018

    authors: Allison MB,Markman L,Rosenberg Z,Vieira RL,Babb J,Tejwani N,Peck V

    更新日期:2013-07-01 00:00:00

  • Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS) 1H NMR spectroscopy.

    abstract::There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2017.08.014

    authors: Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

    更新日期:2017-12-01 00:00:00

  • Bone adaptation: Safety factors and load predictability in shaping skeletal form.

    abstract::Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenet...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2019.115114

    authors: Willie BM,Zimmermann EA,Vitienes I,Main RP,Komarova SV

    更新日期:2020-02-01 00:00:00

  • A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.

    abstract:BACKGROUND:Eldecalcitol is an analog of 1,25-dihydroxyvitamin D(3) that improves bone mineral density; however, the effect of eldecalcitol on the risk of fractures is unclear. The objective of this study is to examine whether eldecalcitol is superior to alfacalcidol in preventing osteoporotic fractures. This trial is r...

    journal_title:Bone

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bone.2011.07.011

    authors: Matsumoto T,Ito M,Hayashi Y,Hirota T,Tanigawara Y,Sone T,Fukunaga M,Shiraki M,Nakamura T

    更新日期:2011-10-01 00:00:00

  • The micro-structure of bone trabecular fracture: an inter-site study.

    abstract::Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2013.12.007

    authors: Tassani S,Matsopoulos GK

    更新日期:2014-03-01 00:00:00

  • Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

    abstract::Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2015.06.014

    authors: Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

    更新日期:2015-10-01 00:00:00

  • Whole body vibration improves osseointegration by up-regulating osteoblastic activity but down-regulating osteoblast-mediated osteoclastogenesis via ERK1/2 pathway.

    abstract::Due to the reduction in bone mass and deterioration in bone microarchitecture, osteoporosis is an important risk factor for impairing implant osseointegration. Recently, low-magnitude, high-frequency (LMHF) vibration (LM: <1×g; HF: 20-90Hz) has been shown to exhibit anabolic, but anti-resorptive effects on skeletal ho...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2014.09.026

    authors: Zhou Y,Guan X,Liu T,Wang X,Yu M,Yang G,Wang H

    更新日期:2015-02-01 00:00:00

  • Examining the causal role of leptin in bone mineral density: A Mendelian randomization study.

    abstract::Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relati...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2019.05.006

    authors: Meng XH,Tan LJ,Xiao HM,Tang BS,Deng HW

    更新日期:2019-08-01 00:00:00

  • Bone recovery after a gluten-free diet: a 5-year follow-up study.

    abstract::The purpose of our study was to investigate the recovery of bone disease in celiac patients during 5 years of a gluten-free diet. The study group consisted of 28 newly diagnosed celiac patients (9 men, 19 women) recruited between 1990 and 1991. Six patients withdrew from the 5-year follow-up. Compliance with the glute...

    journal_title:Bone

    pub_type: 临床试验,杂志文章

    doi:10.1016/s8756-3282(99)00171-4

    authors: Kemppainen T,Kröger H,Janatuinen E,Arnala I,Lamberg-Allardt C,Kärkkäinen M,Kosma VM,Julkunen R,Jurvelin J,Alhava E,Uusitupa M

    更新日期:1999-09-01 00:00:00

  • An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.

    abstract::Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...

    journal_title:Bone

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bone.2009.09.028

    authors: Kumar S,Matheny CJ,Hoffman SJ,Marquis RW,Schultz M,Liang X,Vasko JA,Stroup GB,Vaden VR,Haley H,Fox J,DelMar EG,Nemeth EF,Lago AM,Callahan JF,Bhatnagar P,Huffman WF,Gowen M,Yi B,Danoff TM,Fitzpatrick LA

    更新日期:2010-02-01 00:00:00

  • Cigarette smoking and hip volumetric bone mineral density and cortical volume loss in older adults: The AGES-Reykjavik study.

    abstract::This study aimed to explore the relationships of several indicators of cigarette smoking habits (smoking status, pack-years, age at smoking initiation and smoking cessation) with quantitative computed tomographic (QCT)-derived proximal femur bone measures (trabecular vBMD, integral vBMD and the ratio of cortical to to...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2018.01.014

    authors: Marques EA,Elbejjani M,Gudnason V,Sigurdsson G,Lang T,Sigurdsson S,Aspelund T,Siggeirsdottir K,Launer L,Eiriksdottir G,Harris TB

    更新日期:2018-03-01 00:00:00

  • Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing.

    abstract::Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2015.09.012

    authors: Liu D,Li X,Li J,Yang J,Yokota H,Zhang P

    更新日期:2015-12-01 00:00:00

  • Glucose metabolism in bone.

    abstract::The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults. However, evidence ...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2017.08.008

    authors: Karner CM,Long F

    更新日期:2018-10-01 00:00:00

  • A review of current murine models of multiple myeloma used to assess the efficacy of therapeutic agents on tumour growth and bone disease.

    abstract::Pre-clinical in vivo models of multiple myeloma are essential tools for investigating the pathophysiology of multiple myeloma and for testing new therapeutic agents and strategies prior to their potential use in clinical trials. Over the last five decades, several different types of murine models of multiple myeloma h...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2015.04.004

    authors: Paton-Hough J,Chantry AD,Lawson MA

    更新日期:2015-08-01 00:00:00

  • Bone remodeling and bone matrix quality before and after menopause in healthy women.

    abstract::Acceleration of remodeling activity after menopause leads to bone loss and fragility, however, whether this is associated with modifications of bone matrix quality has been less studied. The impact of variation in bone remodeling rate on bone matrix has been studied mainly in pathologies or anti-osteoporotic treatment...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2019.08.003

    authors: Farlay D,Bala Y,Rizzo S,Bare S,Lappe JM,Recker R,Boivin G

    更新日期:2019-11-01 00:00:00

  • Contrast-enhanced micro-computed tomography of fatigue microdamage accumulation in human cortical bone.

    abstract::Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2010.10.160

    authors: Landrigan MD,Li J,Turnbull TL,Burr DB,Niebur GL,Roeder RK

    更新日期:2011-03-01 00:00:00

  • Use of selective serotonin reuptake inhibitors and bone mass in adolescents: An NHANES study.

    abstract:CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2015.04.042

    authors: Feuer AJ,Demmer RT,Thai A,Vogiatzi MG

    更新日期:2015-09-01 00:00:00

  • In vivo validation of a computational bone adaptation model using open-loop control and time-lapsed micro-computed tomography.

    abstract::Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2011.08.018

    authors: Schulte FA,Lambers FM,Webster DJ,Kuhn G,Müller R

    更新日期:2011-12-01 00:00:00

  • GIT1 is critical for formation of the CD31hiEmcnhi vessel subtype in coupling osteogenesis with angiogenesis via modulating preosteoclasts secretion of PDGF-BB.

    abstract::G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) is a scaffold protein that plays a vital role in bone modeling and remodeling during osteogenesis coupled with angiogenesis. Recent studies have shown that a specialized subset of vascular endothelium strongly positive for CD31 and Endomucin (CD31hiEmcnh...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2019.03.006

    authors: Xu T,Luo Y,Kong F,Lv B,Zhao S,Chen J,Liu W,Cheng L,Zhou Z,Zhou Z,Huang Y,Li L,Zhao X,Qian D,Fan J,Yin G

    更新日期:2019-05-01 00:00:00

  • Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing.

    abstract::The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2009.01.372

    authors: Diederichs G,Link TM,Kentenich M,Schwieger K,Huber MB,Burghardt AJ,Majumdar S,Rogalla P,Issever AS

    更新日期:2009-05-01 00:00:00

  • COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.

    abstract::Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2008.08.109

    authors: Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

    更新日期:2008-12-01 00:00:00

  • Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats.

    abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2005.03.013

    authors: Valenta A,Roschger P,Fratzl-Zelman N,Kostenuik PJ,Dunstan CR,Fratzl P,Klaushofer K

    更新日期:2005-07-01 00:00:00

  • Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.

    abstract::Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2015.05.016

    authors: Harvey NC,Glüer CC,Binkley N,McCloskey EV,Brandi ML,Cooper C,Kendler D,Lamy O,Laslop A,Camargos BM,Reginster JY,Rizzoli R,Kanis JA

    更新日期:2015-09-01 00:00:00