Abstract:
:Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenetic mechanobiology), examining an assemblage of extant vertebrate bones or a group of fossils' bony structures can reveal the combined effects of long-term trends in loading history and the effects of natural selection. In this survey we examine adaptations that take place over both time scales and highlight a few of the extraordinary insights first published by John Currey. First, we provide a historical perspective on bone adaptation control mechanisms, followed by a discussion of safety factors in bone. We then summarize examples of structural- and material-level adaptations and mechanotransduction, and analyze the relationship between these structural- and material-level adaptations observed in situations where loading modes are either predictable or unpredictable. We argue that load predictability is a major consideration for bone adaptation broadly across an evolutionary timescale, but that its importance can also be seen during ontogenetic growth trajectories, which are subject to natural selection as well. Furthermore, we suggest that bones with highly predictable load patterns demonstrate more precise design with lower safety factors, while bones that experience less predictable loads or those that are less capable of repair and adaptation are designed with a higher safety factor. Finally, exposure to rare loading events with high potential costs of failure leads to design of structures with very high safety factor compared to everyday loading experience. Understanding bone adaptations at the structural and material levels, which take place over an individual's lifetime or over evolutionary time has numerous applications in translational and clinical research to understand and treat musculoskeletal diseases, as well as to permit the furthering of human extraterrestrial exploration in environments with altered gravity.
journal_name
Bonejournal_title
Boneauthors
Willie BM,Zimmermann EA,Vitienes I,Main RP,Komarova SVdoi
10.1016/j.bone.2019.115114subject
Has Abstractpub_date
2020-02-01 00:00:00pages
115114eissn
8756-3282issn
1873-2763pii
S8756-3282(19)30407-7journal_volume
131pub_type
杂志文章,评审相关文献
BONE文献大全abstract::Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.10.024
更新日期:2018-02-01 00:00:00
abstract::Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.12.003
更新日期:2013-03-01 00:00:00
abstract::CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Prev...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2013.12.004
更新日期:2014-03-01 00:00:00
abstract::Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue durin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90087-f
更新日期:1990-01-01 00:00:00
abstract::While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.014
更新日期:2012-06-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP-2) is a secreted signaling molecule that acts as an inducer of bone formation and a regulator of embryonic development. The objectives of this work were as follows: (1) to clone the full-length cDNA of BMP-2 in a marine fish model, (2) analyze its gene expression during development, i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.06.021
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Fibrodysplasia ossificans progressiva (FOP) is a rare, disabling genetic disorder characterized by episodic soft tissue swelling (flare-ups) that leads to progressive heterotopic ossification and restricted joint mobility. METHODS:Here we present the first longitudinal patient-reported mobility assessment (...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.06.005
更新日期:2018-04-01 00:00:00
abstract::Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00129-5
更新日期:1999-08-01 00:00:00
abstract::The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115496
更新日期:2020-09-01 00:00:00
abstract:INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.04.002
更新日期:2005-08-01 00:00:00
abstract::The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2020.115729
更新日期:2021-02-01 00:00:00
abstract::Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00362-6
更新日期:1997-03-01 00:00:00
abstract::The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00973-0
更新日期:2003-03-01 00:00:00
abstract::Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.021
更新日期:2014-03-01 00:00:00
abstract::Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also biochemical factors. Adiponectin is a novel adipocyte-derived hormone that regulates energy homeostasis and has anti-inflammatory and anti-atherogenic effects. Unlik...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00237-0
更新日期:2003-10-01 00:00:00
abstract::Because the extracellular matrices of dentin and bone are composed mainly of type I collagen, their characteristics are determined by the nature of noncollagenous proteins (NCPs). Among these NCPs, some proteoglycans (PGs) belong to the small leucine-rich proteoglycans (SLRPs). Recently, osteoadherin (OSAD) has been d...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00310-0
更新日期:2000-08-01 00:00:00
abstract::Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115576
更新日期:2020-12-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115551
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.09.016
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115795
更新日期:2021-03-01 00:00:00
abstract::Osteoarthritis (OA) affects both cartilage and bone tissues, and the subsequent breakdown of the two tissues appears to be interrelated. The interest in the role of subchondral bone changes with OA is growing, and one suggestion is that a simple inverse correlation exists between the cartilage loss and increased bone ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.05.017
更新日期:2009-09-01 00:00:00
abstract::Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00829-3
更新日期:2002-08-01 00:00:00
abstract::Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.04.012
更新日期:2019-07-01 00:00:00
abstract::Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2013.11.011
更新日期:2014-02-01 00:00:00
abstract::Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.175
更新日期:2007-08-01 00:00:00
abstract::Measurement of bone mineral density (BMD) is the clinical gold standard in cases of compromised skeletal integrity, such as with osteoporosis. While BMD is a useful measurement to index skeletal health, it is also limited since it cannot directly assess any mechanical properties. The ability to directly assess mechani...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.01.019
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.129
更新日期:2012-12-01 00:00:00
abstract::During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00027-9
更新日期:2003-04-01 00:00:00
abstract::Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.036
更新日期:2019-06-01 00:00:00
abstract::Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115245
更新日期:2020-04-01 00:00:00