当前位置： SCI文献检索 > BONE期刊下所有文献 > Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints.

Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints.

Abstract：

:Osteoarthritis (OA) affects both cartilage and bone tissues, and the subsequent breakdown of the two tissues appears to be interrelated. The interest in the role of subchondral bone changes with OA is growing, and one suggestion is that a simple inverse correlation exists between the cartilage loss and increased bone mineral density. In this work the STR/ort mouse is used as a model for human OA, in order to investigate disease progression. The aim of the work is to elucidate the tempero-spatial relationships between bone and cartilage architecture and determine whether a simple inverse correlation is satisfactory. We employ 3D whole joint quantitative imaging techniques for assessment of subchondral bone and articular cartilage. The knee joints of mice aged 3, 4, 7 and 10 months are scanned with muCT and then the tibial plateaus are scanned with CLSM. The results show that depending on site (medial and lateral), compartment (epiphyseal, metaphyseal, cortical), and age (3, 4, 7, 10 months), the subchondral bone undergoes changes that lead to an altered architecture. This is primarily seen as densification of the cortex and epiphysis in the STR/ort mice, with a significant change occurring between 7 and 10 months, while the medial cartilage thickness is significantly reduced after 7 months. Using a novel multimodal imaging approach, morphometric changes in the murine osteoarthritic knee joint are elucidated. It is seen that a complex interplay of events - both spatially and temporally - is involved in OA onset and progression. The initial measured differences between the two strains suggest a possible morphological phenotype involved in OA resistance/vulnerability. Temporally the changes have a strong strain:age dependence, although no separate timeline of events between the two tissues could be discerned. Spatially, the changes to medial and lateral morphometry across the cartilage and bone, indicate a relationship to altered joint mechanics.

journal_name

Bone

journal_title

Bone

authors

Stok KS,Pelled G,Zilberman Y,Kallai I,Goldhahn J,Gazit D,Müller R

doi

10.1016/j.bone.2009.05.017

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

414-22

issue

3

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(09)01616-0

journal_volume

45

pub_type

杂志文章

相关文献

BONE文献大全
  • Unbiased stereologic estimation of surface density in bone using vertical sections.

    abstract：:The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random an...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(87)90126-8

    authors： Vesterby A,Kragstrup J,Gundersen HJ,Melsen F

    更新日期：1987-01-01 00:00:00

  • Plasminogen activators are involved in the degradation of bone by osteoclasts.

    abstract：:Osteoclastic bone degradation depends on the activity of several proteolytic enzymes, in particular to those belonging to the classes of cysteine proteinases and matrix metalloproteinases (MMPs). Yet, several findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.07.004

    authors： Everts V,Daci E,Tigchelaar-Gutter W,Hoeben KA,Torrekens S,Carmeliet G,Beertsen W

    更新日期：2008-11-01 00:00:00

  • A new method of comprehensive static histomorphometry applied on human lumbar vertebral cancellous bone.

    abstract：:The aim of the present study was to assess age-related changes in the human spine by use of established static histomorphometry, and to determine how these static histomorphometric measures are interrelated in human cancellous bone tissue. The material comprised normal human lumbar vertebral bodies (L-2) from 12 women...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(00)00285-4

    authors： Thomsen JS,Ebbesen EN,Mosekilde L

    更新日期：2000-07-01 00:00:00

  • Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.

    abstract：:The transcription factor nuclear factor E2 p45-related factor 2 (Nrf2) forms heterodimers with small musculoaponeurotic fibrosarcoma (Maf) proteins for the selective recognition of the antioxidant responsive element on target genes, followed by the regulation of gene expression of phase II detoxifying enzymes as well ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.08.016

    authors： Hinoi E,Takarada T,Fujimori S,Wang L,Iemata M,Uno K,Yoneda Y

    更新日期：2007-02-01 00:00:00

  • The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis.

    abstract：:Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.06.018

    authors： Nagahama K,Aoki K,Nonaka K,Saito H,Takahashi M,Varghese BJ,Shimokawa H,Azuma M,Ohya K,Ohyama K

    更新日期：2004-11-01 00:00:00

  • Atypical incomplete femoral fractures in asymptomatic patients on long term bisphosphonate therapy.

    abstract：OBJECTIVES:Progression of an incomplete atypical femoral fracture (IF) to a complete fracture in patients on long term bisphosphonate (BP) therapy can be catastrophic. We aimed to determine the frequency and imaging features of IF in asymptomatic patients on long-term BP therapy and to identify distinguishing clinical ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.03.018

    authors： Allison MB,Markman L,Rosenberg Z,Vieira RL,Babb J,Tejwani N,Peck V

    更新日期：2013-07-01 00:00:00

  • Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis.

    abstract：:Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/S8756-3282(00)00246-5

    authors： Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

    更新日期：2000-05-01 00:00:00

  • Crosstalk between Activin A and Shh signaling contributes to the proliferation and differentiation of antler chondrocytes.

    abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.03.036

    authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

    更新日期：2019-06-01 00:00:00

  • Fracture risk reduction during treatment with teriparatide is independent of pretreatment bone turnover.

    abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.bone.2006.02.003

    authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

    更新日期：2006-08-01 00:00:00

  • Changes in tibial bone microarchitecture in female recruits in response to 8 weeks of U.S. Army Basic Combat Training.

    abstract：BACKGROUND:U.S. Army Basic Combat Training (BCT) is a physically-demanding program at the start of military service. Whereas animal studies have shown that increased mechanical loading rapidly alters bone structure, there is limited evidence of changes in bone density and structure in humans exposed to a brief period o...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.04.021

    authors： Hughes JM,Gaffney-Stomberg E,Guerriere KI,Taylor KM,Popp KL,Xu C,Unnikrishnan G,Staab JS,Matheny RW Jr,McClung JP,Reifman J,Bouxsein ML

    更新日期：2018-08-01 00:00:00

  • Positive association between the course of vitamin D intake and bone mineral density at 36 years in men.

    abstract：INTRODUCTION:Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.10.055

    authors： van Dijk CE,de Boer MR,Koppes LL,Roos JC,Lips P,Twisk JW

    更新日期：2009-03-01 00:00:00

  • Salmon calcitonin treatment by nasal spray in primary hyperparathyroidism.

    abstract：:The hypocalcemic and hypophosphatemic effect of salmon calcitonin (sCT) given by intranasal (i.n.) spray to 12 patients with histological confirmed primary hyperparathyroidism (1 degree HPT) was studied. The concentration of ionized calcium in whole blood (B-Ca++), serum phosphate (S-P), magnesium (S-Mg), plasma sCT (...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/8756-3282(91)90016-c

    authors： Tørring O,Bucht E,Sjöstedt U,Sjöberg HE

    更新日期：1991-01-01 00:00:00

  • Heterogeneity of trabecular and cortical postmenopausal bone loss: a longitudinal study with pQCT.

    abstract：:Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(96)00362-6

    authors： Hernández ER,Revilla M,Seco-Durban C,Villa LF,Cortés J,Rico H

    更新日期：1997-03-01 00:00:00

  • A novel deletion involving GNAS exon 1 causes PHP1A and further refines the region required for normal methylation at exon A/B.

    abstract：:GNAS exons 1-13 encode the biallelically expressed alpha-subunit of the stimulatory G protein (Gαs). Additional transcripts derived from this locus use alternative first exons that undergo parent-specific methylation, thus allowing transcription only from the non-modified allele. Pseudohypoparathyroidism type Ia (PHP1...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.07.013

    authors： Reyes M,Karaca A,Bastepe M,Gulcelik NE,Jüppner H

    更新日期：2017-10-01 00:00:00

  • Cardiovascular and skeletal safety of zoledronic acid in osteoporosis observational, matched cohort study using Danish and Swedish health registries.

    abstract：BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115296

    authors： Rubin KH,Möller S,Choudhury A,Zorina O,Kalsekar S,Eriksen EF,Andersen M,Abrahamsen B

    更新日期：2020-05-01 00:00:00

  • Microgravity control of autophagy modulates osteoclastogenesis.

    abstract：:Evidence indicates that astronauts experience significant bone loss during space mission. Recently, we used the NASA developed rotary cell culture system (RCCS) to simulate microgravity (μXg) conditions and demonstrated increased osteoclastogenesis in mouse bone marrow cultures. Autophagy is a cellular recycling proce...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.01.004

    authors： Sambandam Y,Townsend MT,Pierce JJ,Lipman CM,Haque A,Bateman TA,Reddy SV

    更新日期：2014-04-01 00:00:00

  • The culture of human osteoblasts upon bone graft substitutes.

    abstract：:In order to assess the ability of six potential bone graft substitutes to support the growth of human osteoblasts, these cells were grown in culture and then plated onto fragments of the six materials and cultured for a further period of 15 days. Tests to confirm the osteoblastic phenotype of the cells included spectr...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(93)90089-s

    authors： Begley CT,Doherty MJ,Hankey DP,Wilson DJ

    更新日期：1993-07-01 00:00:00

  • Bone structure in two adult subjects with impaired minor spliceosome function resulting from RNU4ATAC mutations causing microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1).

    abstract：:Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1), or Taybi-Linder syndrome is characterized by distinctive skeletal dysplasia, severe intrauterine and postnatal growth retardation, microcephaly, dysmorphic features, and neurological malformations. It is an autosomal recessive disorder caused by homozyg...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.08.023

    authors： Krøigård AB,Frost M,Larsen MJ,Ousager LB,Frederiksen AL

    更新日期：2016-11-01 00:00:00

  • The generation of highly enriched osteoclast-lineage cell populations.

    abstract：:Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(01)00654-8

    authors： Quinn JM,Whitty GA,Byrne RJ,Gillespie MT,Hamilton JA

    更新日期：2002-01-01 00:00:00

  • The epiphyseal secondary ossification center: Evolution, development and function.

    abstract：:Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115701

    authors： Xie M,Chagin AS

    更新日期：2021-01-01 00:00:00

  • Walking intensity for postmenopausal bone mineral preservation and accrual.

    abstract：INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2007.06.009

    authors： Borer KT,Fogleman K,Gross M,La New JM,Dengel D

    更新日期：2007-10-01 00:00:00

  • TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics.

    abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.10.007

    authors： Dai JC,He P,Chen X,Greenfield EM

    更新日期：2006-04-01 00:00:00

  • Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity.

    abstract：PURPOSE:Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts is involved in the progression of osteoarthritis (OA). Human osteoblasts isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/ß-catenin pathway, and a reduced mine...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.02.001

    authors： Abed E,Bouvard B,Martineau X,Jouzeau JY,Reboul P,Lajeunesse D

    更新日期：2015-06-01 00:00:00

  • Physical activity in adolescence and bone density in peri- and postmenopausal women: a population-based study.

    abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(97)00148-8

    authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

    更新日期：1997-10-01 00:00:00

  • Anatomic variations of the lacunar-canalicular system influence solute transport in bone.

    abstract：:Solute transport in the lacunar-canalicular system (LCS) is essential for bone metabolism and mechanotransduction. Using the technique of fluorescence recovery after photobleaching (FRAP) we have been quantifying solute transport in the LCS of murine long bone as a function of loading parameters and molecular size. Ho...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.06.026

    authors： Zhou X,Novotny JE,Wang L

    更新日期：2009-10-01 00:00:00

  • The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis - the In Vitro Osteoclast Differentiation in Arthritis (IODA) study.

    abstract：:Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2010.10.167

    authors： Durand M,Boire G,Komarova SV,Dixon SJ,Sims SM,Harrison RE,Nabavi N,Maria O,Manolson MF,Mizianty M,Kurgan L,de Brum-Fernandes AJ

    更新日期：2011-03-01 00:00:00

  • The beneficial effect of icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats.

    abstract：BACKGROUND:Epimedium-derived flavonoids (EFs) have a potential to treat established osteoporosis in postmenopausal women. However, one of the main disadvantages of the compound is the high volume and dosage during long-term administration period. Meanwhile, the beneficial effect of EFs on osteoporotic bone depends grea...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.02.012

    authors： Peng S,Zhang G,Zhang BT,Guo B,He Y,Bakker AJ,Pan X,Zhen W,Hung L,Qin L,Leung WN

    更新日期：2013-07-01 00:00:00

  • Health-related quality of life and cost of ambulatory care in osteoporosis: how may such outcome measures be valuable information to health decision makers and payers?

    abstract：:The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(03)00089-9

    authors： Ethgen O,Tellier V,Sedrine WB,De Maeseneer J,Gosset C,Reginster JY

    更新日期：2003-06-01 00:00:00

  • Long-term fatigue behavior of compact bone at low strain magnitude and rate.

    abstract：:Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue durin...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(90)90087-f

    authors： Schaffler MB,Radin EL,Burr DB

    更新日期：1990-01-01 00:00:00

  • Transmission of whole body vibration - Comparison of three vibration platforms in healthy subjects.

    abstract：:The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115802

    authors： Spain L,Yang L,Wilkinson JM,McCloskey E

    更新日期：2021-03-01 00:00:00