Identification of Sparus aurata bone morphogenetic protein 2: molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates.

abstract：:Although it is generally acknowledged that matrix vesicles and alkaline phosphatase are required for cartilage calcification, their precise role in initiation or propagation of mineralization remains controversial. We have investigated this problem in a neoplastic model of chondrogenesis, the Swarm rat chondrosarcoma....

journal_title：Bone

authors： Miller GJ,DeMarzo AM

更新日期：1988-01-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00

abstract：:Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...

journal_title：Bone

authors： El-Hajj Fuleihan G,Baddoura R,Awada H,Salam N,Salamoun M,Rizk P

更新日期：2002-10-01 00:00:00

abstract：:The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...

journal_title：Bone

authors： Roberts SJ,van Gastel N,Carmeliet G,Luyten FP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...

journal_title：Bone

authors： Alberts Z,Fewtrell M,Nicholls DE,Biassoni L,Easty M,Hudson LD

更新日期：2020-05-01 00:00:00

abstract：:Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...

journal_title：Bone

authors： Pavey GJ,Qureshi AT,Tomasino AM,Honnold CL,Bishop DK,Agarwal S,Loder S,Levi B,Pacifici M,Iwamoto M,Potter BK,Davis TA,Forsberg JA

更新日期：2016-09-01 00:00:00

abstract：:A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of postmenopausal osteoporosis. We have utilized the ovariohysterectomized (Ovh) dog to examine cellular and biochemical responses to estrogen depletion and PTH stim...

journal_title：Bone

authors： Shen V,Dempster DW,Birchman R,Mellish RW,Church E,Kohn D,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...

journal_title：Bone

authors： Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

更新日期：2002-07-01 00:00:00

abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...

journal_title：Bone

authors： Mueller TL,Christen D,Sandercott S,Boyd SK,van Rietbergen B,Eckstein F,Lochmüller EM,Müller R,van Lenthe GH

更新日期：2011-06-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...

journal_title：Bone

authors： Zheng Q,Li XX,Xiao L,Shao S,Jiang H,Zhang XL,Sun LY,Xu HG

更新日期：2019-11-01 00:00:00

abstract：:Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration (LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone. Our previous study found that LMHFV significantly enhanced fracture healing in adult rats. This study was designed to explore whether LMHFV was able t...

journal_title：Bone

authors： Shi HF,Cheung WH,Qin L,Leung AH,Leung KS

更新日期：2010-05-01 00:00:00

abstract：:Osteoarthritis (OA) affects both cartilage and bone tissues, and the subsequent breakdown of the two tissues appears to be interrelated. The interest in the role of subchondral bone changes with OA is growing, and one suggestion is that a simple inverse correlation exists between the cartilage loss and increased bone ...

journal_title：Bone

authors： Stok KS,Pelled G,Zilberman Y,Kallai I,Goldhahn J,Gazit D,Müller R

更新日期：2009-09-01 00:00:00

abstract：:We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Fetal calf serum (FCS) stimulated the formation of choline in a dose-dependent manner in the range between 0.6% and 10%. The effect of a combination of FCS and 12-O-te...

journal_title：Bone

authors： Tokuda H,Suzuki A,Watanabe-Tomita Y,Shinoda J,Imamura Y,Oiso Y,Igata A,Kozawa O

更新日期：1996-10-01 00:00:00

abstract：:Alterations in bone strength and structure were found in knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression of the nicotinic acetylcholine receptors (nAChR) subunit α10 was down-regulated in osteogenic differentiated mesenchymal stem cells of patients with osteo...

journal_title：Bone

authors： Baumann L,Kauschke V,Vikman A,Dürselen L,Krasteva-Christ G,Kampschulte M,Heiss C,Yee KT,Vetter DE,Lips KS

更新日期：2019-03-01 00:00:00

abstract：:The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...

journal_title：Bone

authors： Elffors L,Gullberg B,Allander E,Johnell O,Kanis JA

更新日期：1993-01-01 00:00:00

abstract：:Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...

journal_title：Bone

authors： Leskelä HV,Olkku A,Lehtonen S,Mahonen A,Koivunen J,Turpeinen M,Uusitalo J,Pelkonen O,Kangas L,Selander K,Lehenkari P

更新日期：2006-11-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals ...

journal_title：Bone

authors： Ethgen O,Tellier V,Sedrine WB,De Maeseneer J,Gosset C,Reginster JY

更新日期：2003-06-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

journal_title：Bone

authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

更新日期：2004-06-01 00:00:00

abstract：:Death certification data has shown that death rates due to Paget's disease of bone and osteosarcoma in older people (assumed to be attributable to Paget's) declined in the latter part of the 19th and in the early 20th century, suggesting that there may be a secular trend toward less severe disease. We have reviewed a ...

journal_title：Bone

authors： Cundy T,McAnulty K,Wattie D,Gamble G,Rutland M,Ibbertson HK

更新日期：1997-01-01 00:00:00

abstract：:Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...

journal_title：Bone

authors： Kumar S,Matheny CJ,Hoffman SJ,Marquis RW,Schultz M,Liang X,Vasko JA,Stroup GB,Vaden VR,Haley H,Fox J,DelMar EG,Nemeth EF,Lago AM,Callahan JF,Bhatnagar P,Huffman WF,Gowen M,Yi B,Danoff TM,Fitzpatrick LA

更新日期：2010-02-01 00:00:00

abstract：:We have previously shown that the therapeutic range of ultrasound heals osteoradionecrotic bone and induces bone formation in vitro. It is well established that nitric oxide (NO) and prostaglandins are crucial early mediators in mechanically induced bone formation. The therapeutic range of ultrasound may act in the sa...

journal_title：Bone

authors： Reher P,Harris M,Whiteman M,Hai HK,Meghji S

更新日期：2002-07-01 00:00:00

abstract：CASE REPORT:A female patient with consanguineous parents presented with severe symptomatic hypocalcemia (1.62mmol/l) at the age of 4 months. Treatment with oral 1,25-(OH)2-vitamin D and calcium carbonate was started and serum calcium concentrations were stabilized at the lower end of the normal range. Subsequently she ...

journal_title：Bone

authors： Ertl DA,Stary S,Streubel B,Raimann A,Haeusler G

更新日期：2012-09-01 00:00:00

abstract：:Using immunohistology with two specific antisera raised against N-terminal parathyroid hormone-related protein (PTHrP) and in situ hybridization (riboprobe to common coding exon), evidence is provided for the expression of PTHrP by mouse, rabbit, and human osteoclasts derived from several in vitro and in vivo sources....

journal_title：Bone

authors： Kartsogiannis V,Udagawa N,Ng KW,Martin TJ,Moseley JM,Zhou H

更新日期：1998-03-01 00:00:00

abstract：:The purpose of this study is twofold: (a) to investigate the application of transosseous low-intensity pulsed ultrasound (LiUS) on the enhancement of fracture healing and (b) to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process. A midshaft tibial osteotomy model was used on ...

journal_title：Bone

authors： Malizos KN,Papachristos AA,Protopappas VC,Fotiadis DI

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...

journal_title：Bone

authors： Strube P,Mehta M,Baerenwaldt A,Trippens J,Wilson CJ,Ode A,Perka C,Duda GN,Kasper G

更新日期：2009-12-01 00:00:00

abstract：:This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...

journal_title：Bone

authors： Gibson JH,Harries M,Mitchell A,Godfrey R,Lunt M,Reeve J

更新日期：2000-06-01 00:00:00

abstract：:We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...

journal_title：Bone

authors： Specker B,Binkley T

更新日期：2004-12-01 00:00:00