Function of Ca2+ in phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblast-like cells.

abstract：:The proliferation inhibitor of the macrolide class, everolimus, is a drug shown to be effective in the prevention of organ transplant rejection and to have a potential in the treatment of rheumatoid arthritis and certain cancers. As these diseases or their current treatments are associated with bone loss, we examined ...

journal_title：Bone

authors： Kneissel M,Luong-Nguyen NH,Baptist M,Cortesi R,Zumstein-Mecker S,Kossida S,O'Reilly T,Lane H,Susa M

更新日期：2004-11-01 00:00:00

abstract：:The effect of homologous recombinant porcine growth hormone (r-pGH) on secondary fracture healing was investigated in a diaphyseal defect of the tibia in Yucatan micropigs. A 1 cm defect of the tibia was created surgically and stabilized with an AO 3.5 mm DCP plate. The treatment group (12 animals) received 100 microg...

journal_title：Bone

authors： Raschke M,Kolbeck S,Bail H,Schmidmaier G,Flyvbjerg A,Lindner T,Dahne M,Roenne IA,Haas N

更新日期：2001-10-01 00:00:00

abstract：:Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma of bone and then treated animals with X-radiation therapy. We ...

journal_title：Bone

authors： Margulies BS,DeBoyace SD,Damron TA,Allen MJ

更新日期：2015-10-01 00:00:00

abstract：:We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...

journal_title：Bone

authors： Suzuki K,Aoki K,Ohya K

更新日期：1997-12-01 00:00:00

abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...

journal_title：Bone

authors： Ardawi MS,Maimani AA,Bahksh TA,Rouzi AA,Qari MH,Raddadi RM

更新日期：2010-10-01 00:00:00

abstract：:Mitochondria play a key role in cell physiology including cell differentiation and proliferation. We investigated the changes of mitochondrial biogenesis during Wnt-induced osteoblastic differentiation of murine mesenchymal C3H10T1/2 cells. Scanning electron microscopy demonstrated that activation of Wnt signaling by ...

journal_title：Bone

authors： An JH,Yang JY,Ahn BY,Cho SW,Jung JY,Cho HY,Cho YM,Kim SW,Park KS,Kim SY,Lee HK,Shin CS

更新日期：2010-07-01 00:00:00

abstract：:Background and Purpose Radiotherapy is known to produce long-term skeletal complications. We aim to evaluate the biomechanical effect on femoral neck bone from hypothetical eccentric loads on pre- and post-radiotherapy CT-images for patients treated for rectal cancer. MATERIAL AND METHODS:Pre- and post-radiotherapy C...

journal_title：Bone

authors： Almendros-Abellán VM,Castro-García M,Canales-Vázquez J,Berenguel-Herraiz P,Sabater S

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:In the Fracture Prevention Trial, the risks of any nonvertebral fracture (relative risk [RR] 0.65, P=0.04) and any fragility nonvertebral fracture (RR 0.47, P=0.02) were significantly reduced in the teriparatide 20 μg/day (teriparatide) versus placebo group. The purpose of this analysis was to examine the effic...

journal_title：Bone

authors： Krege JH,Wan X

更新日期：2012-01-01 00:00:00

abstract：:Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenet...

journal_title：Bone

authors： Willie BM,Zimmermann EA,Vitienes I,Main RP,Komarova SV

更新日期：2020-02-01 00:00:00

abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

journal_title：Bone

authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

更新日期：2021-02-01 00:00:00

abstract：:The aim of the present study was to assess age-related changes in the human spine by use of established static histomorphometry, and to determine how these static histomorphometric measures are interrelated in human cancellous bone tissue. The material comprised normal human lumbar vertebral bodies (L-2) from 12 women...

journal_title：Bone

authors： Thomsen JS,Ebbesen EN,Mosekilde L

更新日期：2000-07-01 00:00:00

abstract：:Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus....

journal_title：Bone

authors： Stegen S,van Gastel N,Carmeliet G

更新日期：2015-01-01 00:00:00

abstract：:The degradation of the main fibrillar collagens, collagens I and II, is a crucial process for skeletal development. The most abundant dipeptides generated from the catabolism of collagens contain proline and hydroxyproline. In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino aci...

journal_title：Bone

authors： Besio R,Maruelli S,Gioia R,Villa I,Grabowski P,Gallagher O,Bishop NJ,Foster S,De Lorenzi E,Colombo R,Diaz JL,Moore-Barton H,Deshpande C,Aydin HI,Tokatli A,Kwiek B,Kasapkara CS,Adisen EO,Gurer MA,Di Rocco M,Phang J

更新日期：2015-03-01 00:00:00

abstract：:Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

journal_title：Bone

authors： Mallin MM,Pienta KJ,Amend SR

更新日期：2020-12-03 00:00:00

abstract：:Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal muscle mass and strength in mid-life and then experience a progressive decline of up to 50% by the ninth decade. The loss of muscle mass a...

journal_title：Bone

authors： Aversa Z,Zhang X,Fielding RA,Lanza I,LeBrasseur NK

更新日期：2019-10-01 00:00:00

abstract：:Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...

journal_title：Bone

authors： Chen L,Li D,Li C,Engel A,Deng CX

更新日期：2003-08-01 00:00:00

abstract：:Feral adult female cynomolgus monkeys were divided into three groups and treated for two years: (1) normal controls; (2) weak androgenic treatment (androstenedione+estrone); and (3) strong androgenic treatment (testosterone). The tibiae and the trabecular bone of femoral head from each group were tested mechanically. ...

journal_title：Bone

authors： Kasra M,Grynpas MD

更新日期：1995-09-01 00:00:00

abstract：:Mutations in the GALNT3 gene result in familial tumoral calcinosis, characterized by persistent hyperphosphatemia and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. Nicotinamide is reported to lower serum phosphat...

journal_title：Bone

authors： Reilly AM,Gray AK,Moe SM,Ichikawa S

更新日期：2014-10-01 00:00:00

abstract：:Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...

journal_title：Bone

authors： Shi C,Qi J,Huang P,Jiang M,Zhou Q,Zhou H,Kang H,Qian N,Yang Q,Guo L,Deng L

更新日期：2014-11-01 00:00:00

abstract：:The metabolic fate of whole grafts that were either vascularized or nonvascularized were compared. This study was designed to quantify and correlate changes in bone resorption, formation, and mass in orthotopic, stably fixed, weight-bearing autografts. The grafts were 8-cm segments of the fibula that were internally f...

journal_title：Bone

authors： Klein L,Stevenson S,Shaffer JW,Davy D,Goldberg VM

更新日期：1991-01-01 00:00:00

abstract：:The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro e...

journal_title：Bone

authors： Yianni V,Sharpe PT

更新日期：2020-05-01 00:00:00

abstract：:Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models ...

journal_title：Bone

authors： Bentolila V,Boyce TM,Fyhrie DP,Drumb R,Skerry TM,Schaffler MB

更新日期：1998-09-01 00:00:00

abstract：:This study investigated the possible role in vitro of insulin-like growth factor I (IGF-I) as a mediator of the effects of growth hormone (GH) on osteoclastic resorption in an unfractioned rabbit bone cell model. After 4 days of rabbit bone cell culture, human GH (hGH) (50 ng/mL) and human IGF-I (hIGF-I) (50 ng/mL) si...

journal_title：Bone

authors： Guicheux J,Heymann D,Rousselle AV,Gouin F,Pilet P,Yamada S,Daculsi G

更新日期：1998-01-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often...

journal_title：Bone

authors： Fink HA,Langsetmo L,Vo TN,Orwoll ES,Schousboe JT,Ensrud KE,Osteoporotic Fractures in Men (MrOS) Study Group.

更新日期：2018-08-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:Recently the third generation aromatase inhibitors have proved their efficacy and tolerability compared with tamoxifen in the adjuvant treatment of women with hormone responsive early breast cancer. However, there is some concern about the possible negative impact of these drugs on bone. The aim of the study was to ev...

journal_title：Bone

authors： Gonnelli S,Cadirni A,Caffarelli C,Petrioli R,Montagnani A,Franci MB,Lucani B,Francini G,Nuti R

更新日期：2007-01-01 00:00:00

abstract：:To examine the ability of tamoxifen (TAM) to conserve bone in the estrogen-deficient ovariectomized (OVX) rat in the presence and absence of parathyroid hormone (PTH) six groups of rats with 45Ca-labeled bones were studied for 12 weeks. Rats were OVX, parathyroidectomized (PTX), or given sham operations and treated wi...

journal_title：Bone

authors： Goulding A,Gold E

更新日期：1994-09-01 00:00:00

abstract：:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effect...

journal_title：Bone

authors： Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A

更新日期：2017-12-01 00:00:00

abstract：:Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...

journal_title：Bone

authors： Khajuria DK,Soliman M,Elfar JC,Lewis GS,Abraham T,Kamal F,Elbarbary RA

更新日期：2020-08-01 00:00:00