Abstract:
:The effect of homologous recombinant porcine growth hormone (r-pGH) on secondary fracture healing was investigated in a diaphyseal defect of the tibia in Yucatan micropigs. A 1 cm defect of the tibia was created surgically and stabilized with an AO 3.5 mm DCP plate. The treatment group (12 animals) received 100 microg of r-pGH per kilogram of body weight subcutaneously once per day, whereas the control pigs (12 animals) received 1 mL of sodium chloride as placebo. For evaluation of the GH-axis, serum levels of insulin-like growth factor-I (IGF-I) were sampled every fourth day. The animals were killed 6 weeks after surgery. Quantitative computed tomography (qCT) was performed to determine bone mineral density (BMD) and bone mineral content (BMC) of the defect zone. The torsional stiffness and the torsional failure load were measured by destructive torsional testing of the defect and contralateral tibiae. qCT measurements revealed a significant increase in the BMC of the defect zone in the treatment group compared with controls (GH BMC = 2833 +/- 679 mg, placebo BMC = 2215 +/- 636 mg; p < 0.05), whereas the BMD values were similar in both groups (GH BMD = 668 +/- 60 mg/mm(2), placebo BMD = 629 +/- 52 mg/mm(2), p = 0.12). Torsional failure load was 70% higher and torsional stiffness 83% higher in the treatment group than in the control group (p < 0.05). The mean serum level of IGF-I in the treatment group increased to 382% of the preoperative basal level and decreased to 69% in the control group, and this difference was highly significant (p < 0.001). Our data indicate that daily administration of recombinant GH leads to an increase of serum IGF-I levels and stimulates secondary fracture healing, resulting in increased mechanical strength and stiffness of the callus.
journal_name
Bonejournal_title
Boneauthors
Raschke M,Kolbeck S,Bail H,Schmidmaier G,Flyvbjerg A,Lindner T,Dahne M,Roenne IA,Haas Ndoi
10.1016/s8756-3282(01)00587-7subject
Has Abstractpub_date
2001-10-01 00:00:00pages
368-73issue
4eissn
8756-3282issn
1873-2763pii
S8756-3282(01)00587-7journal_volume
29pub_type
杂志文章相关文献
BONE文献大全abstract::This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.010
更新日期:2010-03-01 00:00:00
abstract::The objects of this study were to determine the responses of a cancellous bone site with a closed growth plate (the distal tibial metaphysis, DTM) to ovariectomy (OVX) and OVX plus a prostaglandin E2 (PGE2) treatment, and compare the site's response to previous findings reported for another site (the proximal tibial m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90700-5
更新日期:1994-03-01 00:00:00
abstract::During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(99)00200-8
更新日期:1999-11-01 00:00:00
abstract::Mandibular condylar cartilage can be distinguished from articular and growth cartilages of long bones based on several differences in morphology, physiology, and function between these structures. However, there is almost no information available on the types of genes that contribute to these differences. In this stud...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.09.048
更新日期:2008-06-01 00:00:00
abstract::Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115610
更新日期:2021-02-01 00:00:00
abstract::Osteoporosis is a common complex disorder with reduced bone mineral density (BMD) and increased susceptibility to fracture. Peak BMD is one of the primary determinants of osteoporotic fracture risk, and is under substantial genetic control. Extracellular matrix, a major component of the bone, influences BMD by regulat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.04.013
更新日期:2014-07-01 00:00:00
abstract::In this study we describe the generation and influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with growth and differentiation factor 5 (GDF-5). Prior to loading GDF-5, we characterized the release profiles from these hydrogels and tested their respective cell viabili...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.11.019
更新日期:2014-02-01 00:00:00
abstract::GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1 encoding a lysosomal β-galactosidase. This disease is a continuum from the severe infantile form with rapid neurological decline to the chronic adult form, which is not life-limiting. The intermediate or type 2 form can be further classifie...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115142
更新日期:2020-02-01 00:00:00
abstract::Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.111
更新日期:2012-11-01 00:00:00
abstract::A macro-micro-nano-multi-level study was conducted to explore age-related structural and mechanical properties of bone, as well as the effects of aging on bone properties. A total of 70 male Wistar rats were used, ranging in the ages of 1, 3, 5, 7, 9, 11, 14, 15, 16, and 17 months (n = 7/age group). After micro-comput...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.03.022
更新日期:2015-07-01 00:00:00
abstract::Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115436
更新日期:2020-08-01 00:00:00
abstract::Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115659
更新日期:2021-02-01 00:00:00
abstract::Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.03.040
更新日期:2014-07-01 00:00:00
abstract::Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115788
更新日期:2020-12-03 00:00:00
abstract::Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignancies resistant to standard treatment we assessed the effect of saracatinib on bone turnover. Fifty-one patients were randomized in...
journal_title:Bone
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.bone.2011.12.017
更新日期:2012-04-01 00:00:00
abstract::The metabolic fate of whole grafts that were either vascularized or nonvascularized were compared. This study was designed to quantify and correlate changes in bone resorption, formation, and mass in orthotopic, stably fixed, weight-bearing autografts. The grafts were 8-cm segments of the fibula that were internally f...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90018-e
更新日期:1991-01-01 00:00:00
abstract::Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00463-x
更新日期:2001-06-01 00:00:00
abstract::Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act as Wnt inhibitors. Small molecule tankyrase inhibitors are being inve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.10.017
更新日期:2018-01-01 00:00:00
abstract::We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.08.012
更新日期:2004-12-01 00:00:00
abstract::Osteoarthritis (OA) affects both cartilage and bone tissues, and the subsequent breakdown of the two tissues appears to be interrelated. The interest in the role of subchondral bone changes with OA is growing, and one suggestion is that a simple inverse correlation exists between the cartilage loss and increased bone ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.05.017
更新日期:2009-09-01 00:00:00
abstract::Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glucocorticoids on protein expression in human osteoblastic cells. Using...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.09.010
更新日期:2004-02-01 00:00:00
abstract::Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00392-6
更新日期:2000-12-01 00:00:00
abstract::Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.05.003
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To evaluate the effects of different definitions of glucocorticoid (GC) exposure on the magnitude and pattern of fracture risk using the same dataset. METHODS:Data from patients with rheumatoid arthritis (RA) were extracted from the Clinical Practice Research Datalink, a primary care database with electronic h...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.004
更新日期:2018-12-01 00:00:00
abstract::Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00092-1
更新日期:1998-09-01 00:00:00
abstract::Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.027
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.04.022
更新日期:2013-09-01 00:00:00
abstract::Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00104-5
更新日期:1998-09-01 00:00:00
abstract::Osteocytes, the most abundant cells in the cortical bone matrix, are thought to have mechanosensory and chemosensory regulatory roles. Marotti theorized that osteocytes signal to osteoblasts to recruit them into the osteocyte lineage. Martin extended this theory, assuming that osteocytes display a general inhibitory e...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00245-x
更新日期:2003-11-01 00:00:00
abstract::Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.05.023
更新日期:2008-10-01 00:00:00