当前位置： SCI文献检索 > BONE期刊下所有文献 > Intracortical remodeling in adult rat long bones after fatigue loading.

Intracortical remodeling in adult rat long bones after fatigue loading.

Abstract：

:Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models for cortical bone turnover processes because of a lack of haversian remodeling activity. Supraphysiological cyclic axial loading of the ulna in vivo was used to induce bending with consequent fatigue and microdamage. Right ulnae of adult Sprague-Dawley rats were fatigue-loaded to a prefailure stopping point of 30% decrease in ulnae whole bone stiffness. Ten days after the first loading, left ulnae were fatigued in the same way. Ulnae were harvested immediately to allow comparison of the immediate response of the left ulna to the fatigue loads, and the biological response of the right leg to the fatigue challenge. Histomorphometry and confocal microscopy of basic fuchsin-stained bone sections were used to assess intracortical remodeling activity, microdamage, and osteocyte integrity. Bone microdamage (linear microcracks, as well as patches of diffuse basic fuchsin staining within the cortex) occurred in fatigue-loaded ulnar diaphyses. Ten days after fatigue loading, intracortical resorption was activated in ulnar cortices. Intracortical resorption occurred in preferential association with linear-type microcracks, with microcrack number density reduced almost 40% by 10 days after fatigue. Resorption spaces were also consistently observed within areas of the cortex in which no bone matrix damage could be detected. Confocal microscopy studies showed alterations of osteocyte and canalicular integrity around these resorption spaces. These studies reveal that: (1) rat bone undergoes intracortical remodeling in response to high levels of cyclic strain, which induce microdamage in the cortex; and (2) intracortical resorption is associated both with bone microdamage and with regions of altered osteocyte integrity. From these studies, we conclude that rats can initiate haversian remodeling in long bones in response to fatigue, and that osteocyte death or damage may provide one of the stimuli for this process.

journal_name

Bone

journal_title

Bone

authors

Bentolila V,Boyce TM,Fyhrie DP,Drumb R,Skerry TM,Schaffler MB

doi

10.1016/s8756-3282(98)00104-5

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

275-81

issue

3

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(98)00104-5

journal_volume

23

pub_type

杂志文章

相关文献

BONE文献大全
  • Bisphosphonates: a review of their pharmacokinetic properties.

    abstract：:Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical p...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/8756-3282(95)00445-9

    authors： Lin JH

    更新日期：1996-02-01 00:00:00

  • Genetic lineage, bone mass, and physical activity in mice.

    abstract：:Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(00)00164-2

    authors： Kaye M,Kusy RP

    更新日期：1995-08-01 00:00:00

  • Effect of 1 alpha-hydroxyvitamin D3 on osteoporosis induced by immobilization combined with ovariectomy in rats.

    abstract：:The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(87)90066-4

    authors： Okumura H,Yamamuro T,Kasai R,Hayashi T,Tada K,Nishii Y

    更新日期：1987-01-01 00:00:00

  • The clover and heart signs in vertebral scintigraphic images are highly specific of Paget's disease of bone.

    abstract：BACKGROUND:Bone scintigraphy used as a diagnostic technique frequently yields non-specific intense uptake by vertebrae. Bone biopsy may therefore be required to establish a diagnosis in cases of Paget's disease of bone. The aim of the study was to ascertain the sensitivity and specificity of two new images-heart sign a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2003.10.014

    authors： Rotés-Sala D,Monfort J,Solano A,Miralles E,Vila J,Carbonell J

    更新日期：2004-04-01 00:00:00

  • Ultrashort echo time magnetic resonance imaging (UTE-MRI) of cortical bone correlates well with histomorphometric assessment of bone microstructure.

    abstract：:Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores small...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.03.013

    authors： Jerban S,Ma Y,Wong JH,Nazaran A,Searleman A,Wan L,Williams J,Du J,Chang EY

    更新日期：2019-06-01 00:00:00

  • The Conneulor: unbiased estimation of connectivity using physical disectors under projection.

    abstract：:The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(93)90144-y

    authors： Gundersen HJ,Boyce RW,Nyengaard JR,Odgaard A

    更新日期：1993-05-01 00:00:00

  • Biomechanical properties of bone treated by magnetic resonance-guided focused ultrasound - an in vivo porcine model study.

    abstract：:The magnetic resonance-guided focused ultrasound (MRgFUS) system uses MR imaging for real-time aiming of thermal ablation of bone and soft tissue tumors. Past clinical studies showed no increase in fracture rate after MRgFUS treatment. The purpose of this study was to determine the effect of MRgFUS treatment on mechan...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.06.032

    authors： Herman A,Avivi E,Brosh T,Schwartz I,Liberman B

    更新日期：2013-11-01 00:00:00

  • Quality control for bone quality parameters affected by subject motion in high-resolution peripheral quantitative computed tomography.

    abstract：:Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2012.03.003

    authors： Pauchard Y,Liphardt AM,Macdonald HM,Hanley DA,Boyd SK

    更新日期：2012-06-01 00:00:00

  • Serum periostin is associated with cancer mortality but not cancer risk in older home-dwelling men: A 8-year prospective analysis of the STRAMBO study.

    abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.115184

    authors： Rousseau JC,Bertholon C,Chapurlat R,Szulc P

    更新日期：2020-03-01 00:00:00

  • The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

    abstract：:Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115665

    authors： Andes FT,Adam S,Hahn M,Aust O,Frey S,Grueneboom A,Nitschke L,Schett G,Steffen U

    更新日期：2021-02-01 00:00:00

  • Early detection of burn induced heterotopic ossification using transcutaneous Raman spectroscopy.

    abstract：INTRODUCTION:Heterotopic ossification (HO), or the abnormal formation of bone in soft tissue, occurs in over 60% of major burn injuries and blast traumas. A significant need exists to improve the current diagnostic modalities for HO which are inadequate to diagnose and intervene on HO at early time-points. Raman spectr...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.01.002

    authors： Peterson JR,Okagbare PI,De La Rosa S,Cilwa KE,Perosky JE,Eboda ON,Donneys A,Su GL,Buchman SR,Cederna PS,Wang SC,Kozloff KM,Morris MD,Levi B

    更新日期：2013-05-01 00:00:00

  • Effects of biomechanical stress on bones in animals.

    abstract：:The signals that allow bone to adapt to its mechanical environment most likely involve strain-mediated fluid flow through the canalicular channels. Fluid can only be moved through bone by cyclic loading, and the shear stresses generated on bone cells are proportional to the rate of loading. The proportional relation b...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/s8756-3282(02)00707-x

    authors： Burr DB,Robling AG,Turner CH

    更新日期：2002-05-01 00:00:00

  • Intravital bone imaging by two-photon excitation microscopy to identify osteocytic osteolysis in vivo.

    abstract：:Bone is a highly dynamic organ in which several cell types function cooperatively. Among these, osteocytes have recently emerged as an important regulator of bone homeostasis, although their mechanism of regulation is unclear. Here, intravital bone imaging by two-photon excitation microscopy allowed us to directly vis...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.01.013

    authors： Sano H,Kikuta J,Furuya M,Kondo N,Endo N,Ishii M

    更新日期：2015-05-01 00:00:00

  • The axolotl limb: a model for bone development, regeneration and fracture healing.

    abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.07.005

    authors： Hutchison C,Pilote M,Roy S

    更新日期：2007-01-01 00:00:00

  • The short- and long-term effects of methotrexate on the rat skeleton.

    abstract：:Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has adverse short-term effects on bone. There are no studies that demonstrate the long-term response of bone to MTX. The purpose of this study was to determine the short- and long-term effects of MTX on bone volume, turnove...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(94)00032-u

    authors： Wheeler DL,Vander Griend RA,Wronski TJ,Miller GJ,Keith EE,Graves JE

    更新日期：1995-02-01 00:00:00

  • Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass.

    abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.07.014

    authors： Blom-Høgestøl IK,Hewitt S,Chahal-Kummen M,Brunborg C,Gulseth HL,Kristinsson JA,Eriksen EF,Mala T

    更新日期：2019-10-01 00:00:00

  • The natural history of vertebral osteoporosis. Is low bone mass an epiphenomenon?

    abstract：:Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(92)90192-y

    authors： Heaney RP

    更新日期：1992-01-01 00:00:00

  • Advanced quantitative imaging and biomechanical analyses of periosteal fibers in accelerated bone growth.

    abstract：PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.08.021

    authors： Chaudhary R,Lee MS,Mubyana K,Duenwald-Kuehl S,Johnson L,Kaiser J,Vanderby R Jr,Eliceiri KW,Corr DT,Chin MS,Li WJ,Campagnola PJ,Halanski MA

    更新日期：2016-11-01 00:00:00

  • Bone mineralization density and femoral neck fragility.

    abstract：:The traditional view of osteoporotic fractures is that they result from a reduction in bone mass combined with alterations in the micro-architecture. Apart from the effects of bone remodeling, the material properties of the remaining bone are thought to be unaffected. To test this, we compared the degree of matrix min...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.05.025

    authors： Loveridge N,Power J,Reeve J,Boyde A

    更新日期：2004-10-01 00:00:00

  • Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.

    abstract：:Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch indivi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：

    authors： Oei L,Estrada K,Duncan EL,Christiansen C,Liu CT,Langdahl BL,Obermayer-Pietsch B,Riancho JA,Prince RL,van Schoor NM,McCloskey E,Hsu YH,Evangelou E,Ntzani E,Evans DM,Alonso N,Husted LB,Valero C,Hernandez JL,Lewis JR,

    更新日期：2014-02-01 00:00:00

  • High molecular weight tropomyosins regulate osteoclast cytoskeletal morphology.

    abstract：:Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they can broadly be classified into two groups based on protein size, that is, high molecular weight a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.06.017

    authors： Kotadiya P,McMichael BK,Lee BS

    更新日期：2008-11-01 00:00:00

  • Gene expression profiles give insight into the molecular pathology of bone in primary hyperparathyroidism.

    abstract：:Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.12.020

    authors： Reppe S,Stilgren L,Olstad OK,Brixen K,Nissen-Meyer LS,Gautvik KM,Abrahamsen B

    更新日期：2006-07-01 00:00:00

  • Polymorphisms in genes implicated in base excision repair (BER) pathway are associated with susceptibility to Paget's disease of bone.

    abstract：:Paget's disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is the second most frequent bone disorder. PDB is a focal disorder affecting the skeleton segmentally but the cause of which is unknown. It has been hypothesised that somatic mutations could be responsible for the mosaicism described in...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.04.003

    authors： Usategui-Martín R,Gutiérrez-Cerrajero C,Jiménez-Vázquez S,Calero-Paniagua I,García-Aparicio J,Corral-Gudino L,Del Pino-Montes J,González-Sarmiento R

    更新日期：2018-07-01 00:00:00

  • Hip structural geometry in old and old-old age: similarities and differences between men and women.

    abstract：INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2007.06.001

    authors： Yates LB,Karasik D,Beck TJ,Cupples LA,Kiel DP

    更新日期：2007-10-01 00:00:00

  • Interaction between human umbilical vein endothelial cells and human osteoprogenitors triggers pleiotropic effect that may support osteoblastic function.

    abstract：:Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence that endothelial cells are involved in the modulation of osteoblast differentiation. We hypothesized that primary human umbilical vein endothelial cells (HUVEC) should be able to modulate primary human osteoprogenitors (HOP) funct...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.01.025

    authors： Guillotin B,Bareille R,Bourget C,Bordenave L,Amédée J

    更新日期：2008-06-01 00:00:00

  • Physical activity in adolescence and bone density in peri- and postmenopausal women: a population-based study.

    abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(97)00148-8

    authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

    更新日期：1997-10-01 00:00:00

  • An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.

    abstract：:Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2009.09.028

    authors： Kumar S,Matheny CJ,Hoffman SJ,Marquis RW,Schultz M,Liang X,Vasko JA,Stroup GB,Vaden VR,Haley H,Fox J,DelMar EG,Nemeth EF,Lago AM,Callahan JF,Bhatnagar P,Huffman WF,Gowen M,Yi B,Danoff TM,Fitzpatrick LA

    更新日期：2010-02-01 00:00:00

  • Clinical burden and incremental cost of fractures in postmenopausal women in the United Kingdom.

    abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2012.05.020

    authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

    更新日期：2012-09-01 00:00:00

  • The key role of proinflammatory cytokines, matrix proteins, RANKL/OPG and Wnt/β-catenin in bone healing of hip arthroplasty patients.

    abstract：INTRODUCTION:We still lack understanding of why some implants fail while most remain stable after decades of use. Proinflammatory cytokines, matrix proteins and bone regulating cytokines of the RANKL/OPG (receptor activator of nuclear factor kappa B ligand/osteoprotegerin) and Wnt/β-catenin pathways are mandatory for n...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.11.004

    authors： Cassuto J,Folestad A,Göthlin J,Malchau H,Kärrholm J

    更新日期：2018-02-01 00:00:00

  • Novel therapeutic interventions for pseudoachondroplasia.

    abstract：:Pseudoachondroplasia (PSACH), a severe short-limbed dwarfing condition, is associated with life-long joint pain and early onset osteoarthritis. PSACH is caused by mutations in cartilage oligomeric matrix protein (COMP), a pentameric matricellular protein expressed primarily in cartilage and other musculoskeletal tissu...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/j.bone.2017.03.045

    authors： Posey KL,Hecht JT

    更新日期：2017-09-01 00:00:00