Abstract:
:This study investigated the possible role in vitro of insulin-like growth factor I (IGF-I) as a mediator of the effects of growth hormone (GH) on osteoclastic resorption in an unfractioned rabbit bone cell model. After 4 days of rabbit bone cell culture, human GH (hGH) (50 ng/mL) and human IGF-I (hIGF-I) (50 ng/mL) significantly increased the formation of osteoclast-like cells with a lower level than parathyroid hormone (50 ng/mL) or VD3 (10(-8) mol/L). As well as parathyroid hormone and 1-alpha,25-dihydroxyvitamin D3, addition of hGH (1, 10, and 50 ng/mL) and hIGF-I (1, 10, and 50 ng/mL) stimulated the resorption activity of osteoclasts in terms of the percentage of dentin slice surface resorbed, number of lacunae per surface unit, and mean area of lacunae as compared to the control. When neutralizing antiserum against hIGF-I (4 micrograms/mL) was added at the start of culture, the stimulatory effects of hIGF-I and hGH on osteoclastic resorption activity were totally abolished. These results indicate that the effects of GH stimulation on osteoclastic resorption in vitro are mediated via local IGF-I secretion by stromal cells such as osteoblasts. As IGF-I receptors have recently been reported on rabbit osteoclasts, a direct action of IGF-I on mature osteoclasts could be envisaged. Further experiments will be required to determine the real level of IGF-I implicated in the stimulation of bone osteoclastic resorption.
journal_name
Bonejournal_title
Boneauthors
Guicheux J,Heymann D,Rousselle AV,Gouin F,Pilet P,Yamada S,Daculsi Gdoi
10.1016/s8756-3282(97)00224-xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
25-31issue
1eissn
8756-3282issn
1873-2763pii
S8756-3282(97)00224-Xjournal_volume
22pub_type
杂志文章相关文献
BONE文献大全abstract::Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(88)90115-9
更新日期:1988-01-01 00:00:00
abstract::Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulated to regulate the o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.12.013
更新日期:2018-03-01 00:00:00
abstract::Osteoporosis is a common complex disorder with reduced bone mineral density (BMD) and increased susceptibility to fracture. Peak BMD is one of the primary determinants of osteoporotic fracture risk, and is under substantial genetic control. Extracellular matrix, a major component of the bone, influences BMD by regulat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.04.013
更新日期:2014-07-01 00:00:00
abstract::Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00778-0
更新日期:2002-07-01 00:00:00
abstract::Teeth with intact crowns rarely split or fracture, despite decades of cyclic loading and occasional unexpected overload. This is largely attributed to the presence of dentine, since cracking and fracture of enamel have been frequently reported. Dentine is similar to bone, comprising mineralised collagen fibres as a ma...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115178
更新日期:2020-03-01 00:00:00
abstract::Suppression of bone remodeling by bisphosphonates leads to accumulation of microdamage in bone. If this microdamage develops due to suppressed repair of remodeling only, more potent bisphosphonates should cause more damage. In this study, we evaluated the effects of reduced bone turnover produced by a potent bisphosph...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.016
更新日期:2013-05-01 00:00:00
abstract::Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.02.005
更新日期:2012-05-01 00:00:00
abstract::Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence that endothelial cells are involved in the modulation of osteoblast differentiation. We hypothesized that primary human umbilical vein endothelial cells (HUVEC) should be able to modulate primary human osteoprogenitors (HOP) funct...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.01.025
更新日期:2008-06-01 00:00:00
abstract::To investigate whether exercise training can produce increases in bone mass in spinal cord-injured (SCI) individuals with established disuse osteopenia, nine subjects (age 28.2 years, time since injury 6.0 years, level of injury C5-T7) were recruited for a 9-month training program using functional electrical stimulati...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(96)00109-3
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures. METHODS:A population of Caucasian women (30-90 years), enrolled from 2013 to 2016, underwent dual X-ray absorpti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115297
更新日期:2020-05-01 00:00:00
abstract::Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90004-g
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115772
更新日期:2021-01-01 00:00:00
abstract::We report the establishment in vitro of three-dimensional (3D) cultures of human osteoblasts (hOB) derived from normal adults and supported uniquely by the extracellular matrix (ECM) they deposit. Osteoblasts were cultured in 3D cultures in vitro for up to 120 days. The 3D cultures, examined at 25, 31, and 48 days, ex...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00691-9
更新日期:2002-05-01 00:00:00
abstract::Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.022
更新日期:2014-09-01 00:00:00
abstract::Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.12.007
更新日期:2009-04-01 00:00:00
abstract::Levels of circulating cytokines are elevated in inflammatory diseases. Previously, it was shown that interleukin (IL-)17A, in synergism with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and tumor necrosis factor α (TNFα), induces the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) by murine osteoblasts ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.01.036
更新日期:2017-04-01 00:00:00
abstract::Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.013
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) are at high risk for fracture. The ability of bone mineral density (BMD) to predict fractures in CKD patients has been inconsistent. Other measures such as trabecular bone score (TBS) and impact microindentation (IMI) may be more useful in this group. This study aim...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115241
更新日期:2020-04-01 00:00:00
abstract::High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.05.005
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the experimental anterior cruciate ligament (ACL) dog model of osteoarthritis (OA) and analyze concomitant changes in the level of MMP-13 and cathepsin K, as well as examine the therapeutic effects of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.11.021
更新日期:2004-03-01 00:00:00
abstract::Active vitamin D is a major therapeutic agent for bone disease. Although some studies have reported that vitamin D ameliorates bone disease related to diabetes, the mechanism remains unclear. Our study investigated the effect of the vitamin D receptor activator 22-oxacalcitriol (OCT) on bone disease in a rat model of ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.01.014
更新日期:2015-05-01 00:00:00
abstract::Osteopontin (OPN) gene expression and alkaline phosphatase activity were evaluated in the epiphyseal growth plates of normal chickens and in diet-induced tibial dyschdroplasia (TD)-afflicted chickens. In the normal growth plate, OPN gene was expressed by a) cells of the subperichondrial zone surrounding the articular ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)00048-5
更新日期:1995-04-01 00:00:00
abstract::This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.05.020
更新日期:2012-09-01 00:00:00
abstract::As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2015.07.001
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115184
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Since July 1, 2006 bone mineral density (BMD) testing has been reimbursed for osteoporosis screening under specific clinical conditions in France. Concurrently, drug coverage has been extended to all anti-osteoporotic treatments in women with low BMD. It was thus expected that the utilisation of BMD testing ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.06.026
更新日期:2010-10-01 00:00:00
abstract::A recurrent aneurysmal bone cyst of the proximal phalanx of the index finger of a three-year-old child, treated with bioactive glass, is presented. Over a two-year follow-up, the treated area appeared dense on X-rays. At two years, no cavity was observed and the homogenous region resembled normal trabecular bone. The ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.04.195
更新日期:2009-08-01 00:00:00
abstract::Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.05.006
更新日期:2019-08-01 00:00:00
abstract::To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout. Although suppression of the ligand to the ERs (i.e., estradiol) after menopause or gonadectomy in females...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00643-3
更新日期:2002-01-01 00:00:00