Abstract：
:Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, only a few of the measured sites will represent walls formed under the new conditions. With a reconstruction of the formative site true information of the performed osteoblastic work can be obtained, since it is based upon observations of the actual formative events and not the end result (completed walls). Previously published methods have the disadvantage of being time consuming and technically difficult. Furthermore, the method by Eriksen et al. includes rather complicated mathematical calculations. In the present study a new method for reconstruction of the formative phase is presented, which can be performed from measurements normally obtained in a routine histomorphometric analysis and from paired values of osteoid thicknesses and uncompleted wall thickness. The method does not introduce a new time consuming step in the histomorphometric analyses of the bone biopsy. Furthermore, calculations needed to reconstruct the events of the formative phase can easily be performed using a personal computer and a spread-sheet. The new method for reconstruction presented in this paper gives growth curves for matrix and bone mineral, which are virtually identical with the growth curves previously published by Eriksen et al. for the same 20 normal individuals.
journal_name
Bonejournal_title
Boneauthors
Steiniche T,Eriksen EF,Kudsk H,Mosekilde L,Melsen Fdoi
10.1016/8756-3282(92)90004-gsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
147-52issue
2eissn
8756-3282issn
1873-2763pii
8756-3282(92)90004-Gjournal_volume
13pub_type
杂志文章相关文献
BONE文献大全abstract：:The influence of TGF beta 1 on bone was studied in a titanium device implanted into the tibia of rabbits. TGF beta 1 was infused via an Alzet osmotic pump calibrated to deliver at a rated of 200ng daily for 2 weeks before replacement. A hollow channel is incorporated into the device into which tissue can grow, and the...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00324-7
更新日期：1995-10-01 00:00:00
abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(90)90070-f
更新日期：1990-01-01 00:00:00
abstract：:In an attempt to elucidate the biochemical defect in pseudoachondroplasia, proteoglycan metabolism was investigated in cartilage from a patient with the dominant form of this condition. Iliac-crest cartilage was radioactively labeled with 35S-sulfate and the newly synthesized proteoglycans examined for their hydrodyna...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90118-4
更新日期：1988-01-01 00:00:00
abstract：:Identification of a reliable marker of skeletal precursor cells within calcified and soft tissues remains a major challenge for the field. To address this, we used a transgenic model in which osteoblasts can be eliminated by pharmacological treatment. Following osteoblast ablation a dramatic increase in a population o...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.04.023
更新日期：2008-09-01 00:00:00
abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115576
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115702
更新日期：2021-01-01 00:00:00
abstract：:Recent reports showed a high frequency of osteopenia/osteoporosis in HIV-infected subjects. Mechanism on the basis of this alteration is still unclear, as the direct effect of virus or of antiretroviral drugs. One hundred sixty-one consecutive HIV-infected outpatients aged 30-50 years, both naive and HAART-treated for...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.11.001
更新日期：2006-06-01 00:00:00
abstract：UNLABELLED:We identified regions inside the proximal femur that are most strongly associated with hip fracture. Bone densitometry based on such fracture-critical regions showed improved power in discriminating fracture patients from controls. INTRODUCTION:Hip fractures typically occur in lateral falls, with focal mech...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.12.008
更新日期：2009-04-01 00:00:00
abstract：:Fracture healing is a regenerative process in which bone is restored without scar tissue formation. The healing cascade initiates with a cycle of inflammation, cell migration, proliferation and differentiation. Immune cells invade the fracture site immediately upon bone damage and contribute to the initial phase of th...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2014.03.052
更新日期：2014-07-01 00:00:00
abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90018-x
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...
journal_title：Bone
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.bone.2008.11.001
更新日期：2009-03-01 00:00:00
abstract：:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.01.008
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) s...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.019
更新日期：2019-06-01 00:00:00
abstract：:Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.011
更新日期：2004-07-01 00:00:00
abstract：:Changes in skeletal remodeling (biochemical bone markers) and regional bone mineral density (spine, hip, and forearm bone mineral density [BMD]) were observed for 3 years in 20 patients (15 women and 5 men; age 54 +/- 11 years, range 29-69 years) after successful surgery for primary hyperparathyroidism (PHPT). Fifteen...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/s8756-3282(99)00207-0
更新日期：1999-11-01 00:00:00
abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2021.115841
更新日期：2021-01-06 00:00:00
abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.05.002
更新日期：2013-09-01 00:00:00
abstract：:Bone remodeling is a process involving both dynamic and static bone strain. Although there exist numerous studies on the effect of dynamic strain on implant stability and bone remodeling, the effect of static strain has yet to be clarified. Hence, for this purpose, the effect of static bone strain on implant stability...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.07.003
更新日期：2011-10-01 00:00:00
abstract：:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(03)00059-0
更新日期：2003-05-01 00:00:00
abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(02)00681-6
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as potential effect modification by apolipoprotein E gene (APOE) status by presence of...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.07.035
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.08.005
更新日期：2009-12-01 00:00:00
abstract：:In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.08.012
更新日期：2016-11-01 00:00:00
abstract：:Bone is a highly dynamic organ in which several cell types function cooperatively. Among these, osteocytes have recently emerged as an important regulator of bone homeostasis, although their mechanism of regulation is unclear. Here, intravital bone imaging by two-photon excitation microscopy allowed us to directly vis...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.01.013
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bon...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.11.041
更新日期：2013-03-01 00:00:00
abstract：:Juvenile osteoporosis (JO) is characterized by bone fragility during development, low bone mass and absence of extraskeletal features. Heterozygous loss-of-function mutations in LRP5 have been found in a few patients, but bone tissue and bone material abnormalities associated with such mutations have not been determin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.07.020
更新日期：2013-11-01 00:00:00
abstract：:Sclerostin monoclonal antibody (Scl-Ab) has been shown to increase bone mass and bone strength by stimulating bone formation in an ovariectomy-induced bone loss rat model. The purpose of this study was to determine the effects of Scl-Ab in a rat immobilization/disuse model in which there was both a decrease in bone fo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.09.009
更新日期：2011-02-01 00:00:00
abstract：:Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bon...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.02.006
更新日期：2005-05-01 00:00:00
abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.05.027
更新日期：2015-10-01 00:00:00
abstract：:Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.12.004
更新日期：2005-03-01 00:00:00
