Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males.

abstract：:Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...

journal_title：Bone

authors： Tankó LB,Bagger YZ,Nielsen SB,Christiansen C

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...

journal_title：Bone

authors： Frost M,Tencerova M,Andreasen CM,Andersen TL,Ejersted C,Svaneby D,Qui W,Kassem M,Zarei A,McAlister WH,Veis DJ,Whyte MP,Frederiksen AL

更新日期：2019-04-01 00:00:00

abstract：:Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...

journal_title：Bone

authors： Geraets WG,Van der Stelt PF,Lips P,Van Ginkel FC

更新日期：1998-02-01 00:00:00

abstract：INTRODUCTION:High plasma homocysteine (Hcy) levels have been associated with increased risk of fracture. Since Hcy has been shown to induce apoptosis in many cell types, including vascular endothelial cells, we hypothesized that Hcy would have a similar apoptotic effect on osteoblasts, leading to osteoporosis by reduci...

journal_title：Bone

authors： Kim DJ,Koh JM,Lee O,Kim NJ,Lee YS,Kim YS,Park JY,Lee KU,Kim GS

更新日期：2006-09-01 00:00:00

abstract：:We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...

journal_title：Bone

authors： Davis JW,Ross PD,Johnson NE,Wasnich RD

更新日期：1995-10-01 00:00:00

abstract：:Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...

journal_title：Bone

authors： Davis JW,Grove JS,Wasnich RD,Ross PD

更新日期：1999-03-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:Paralysis of the masticatory muscles using botulinum toxin (BTX) is a common treatment for cosmetic reduction of the masseters as well as for conditions involving muscle spasm and pain. The effects of this treatment on mastication have not been evaluated, and claims that the treatment unloads the jaw joint and mandibl...

journal_title：Bone

authors： Rafferty KL,Liu ZJ,Ye W,Navarrete AL,Nguyen TT,Salamati A,Herring SW

更新日期：2012-03-01 00:00:00

abstract：AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...

journal_title：Bone

authors： Zhang G,Qin L,Hung WY,Shi YY,Leung PC,Yeung HY,Leung KS

更新日期：2006-06-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00

abstract：:An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on...

journal_title：Bone

authors： Fahrleitner-Pammer A,Burr D,Dobnig H,Stepan JJ,Petto H,Li J,Krege JH,Pavo I

更新日期：2016-08-01 00:00:00

abstract：:Spinal cord injury (SCI) causes profound bone loss due to muscle paralysis resulting in the inability to walk. Sclerostin, a Wnt signaling pathway antagonist produced by osteocytes, is a potent inhibitor of bone formation. Short-term studies in rodent models have demonstrated increased sclerostin in response to mechan...

journal_title：Bone

authors： Battaglino RA,Sudhakar S,Lazzari AA,Garshick E,Zafonte R,Morse LR

更新日期：2012-09-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：:Cylindrical trabecular bone specimens (d = 7 mm) were drilled in a vertical direction from the central part of the third vertebral body (L3) from 23 normal individuals aged 15-87 years (10 males and 13 females). The bone samples were embedded in methylmetacrylate and sawn in 400 microns thick sections with an arbitrar...

journal_title：Bone

authors： Mosekilde L

更新日期：1988-01-01 00:00:00

abstract：:In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...

journal_title：Bone

authors： Palvanen M,Kannus P,Niemi S,Parkkari J

更新日期：2010-05-01 00:00:00

abstract：:Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...

journal_title：Bone

authors： Hernández ER,Revilla M,Seco-Durban C,Villa LF,Cortés J,Rico H

更新日期：1997-03-01 00:00:00

abstract：:We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Fetal calf serum (FCS) stimulated the formation of choline in a dose-dependent manner in the range between 0.6% and 10%. The effect of a combination of FCS and 12-O-te...

journal_title：Bone

authors： Tokuda H,Suzuki A,Watanabe-Tomita Y,Shinoda J,Imamura Y,Oiso Y,Igata A,Kozawa O

更新日期：1996-10-01 00:00:00

abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

journal_title：Bone

authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

更新日期：2007-04-01 00:00:00

abstract：:While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...

journal_title：Bone

authors： Omata Y,Frech M,Lucas S,Primbs T,Knipfer L,Wirtz S,Kadono Y,Saito T,Tanaka S,Sarter K,Schett G,Zaiss MM

更新日期：2020-07-01 00:00:00

abstract：:End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...

journal_title：Bone

authors： Zheng Q,Li XX,Xiao L,Shao S,Jiang H,Zhang XL,Sun LY,Xu HG

更新日期：2019-11-01 00:00:00

abstract：:Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenet...

journal_title：Bone

authors： Willie BM,Zimmermann EA,Vitienes I,Main RP,Komarova SV

更新日期：2020-02-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:This study investigated the possible role in vitro of insulin-like growth factor I (IGF-I) as a mediator of the effects of growth hormone (GH) on osteoclastic resorption in an unfractioned rabbit bone cell model. After 4 days of rabbit bone cell culture, human GH (hGH) (50 ng/mL) and human IGF-I (hIGF-I) (50 ng/mL) si...

journal_title：Bone

authors： Guicheux J,Heymann D,Rousselle AV,Gouin F,Pilet P,Yamada S,Daculsi G

更新日期：1998-01-01 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...

journal_title：Bone

authors： Rubin KH,Möller S,Choudhury A,Zorina O,Kalsekar S,Eriksen EF,Andersen M,Abrahamsen B

更新日期：2020-05-01 00:00:00

abstract：:Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...

journal_title：Bone

authors： He L,Lee J,Jang JH,Lee SH,Nan MH,Oh BC,Lee SG,Kim HH,Soung NK,Ahn JS,Kim BY

更新日期：2012-06-01 00:00:00

abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

journal_title：Bone

authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

更新日期：2003-09-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00