Homocysteine enhances apoptosis in human bone marrow stromal cells.

abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...

journal_title：Bone

authors： Rubin KH,Abrahamsen B,Friis-Holmberg T,Hjelmborg JV,Bech M,Hermann AP,Barkmann R,Glüer CC,Brixen K

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION AND HYPOTHESIS:Diagnosis of prevalent osteoporotic vertebral fracture is complicated by normal or developmental variation in vertebral shape or size and non-osteoporotic deformities that appear to have 'reduced' height. Using our visual approach, the algorithm-based qualitative method (ABQ) a vertebra with...

journal_title：Bone

authors： Ferrar L,Jiang G,Armbrecht G,Reid DM,Roux C,Glüer CC,Felsenberg D,Eastell R

更新日期：2007-07-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is now defined by the presence of exposed bone in the mouth, which fails to heal after appropriate intervention over a period of six or eight weeks. It is commonly precipitated by a tooth extraction in patients treated with zoledronate, pamidronate or a combination of these agents, for t...

journal_title：Bone

authors： Reid IR

更新日期：2009-01-01 00:00:00

abstract：:The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...

journal_title：Bone

authors： Aoyagi M,Sasaki T,Ramamurthy NS,Golub LM

更新日期：1996-12-01 00:00:00

abstract：:Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other tha...

journal_title：Bone

authors： Hatano K,Inoue H,Kojo T,Matsunaga T,Tsujisawa T,Uchiyama C,Uchida Y

更新日期：1999-10-01 00:00:00

abstract：:The effects of pregnancy and lactation on bone histomorphometry have been studied extensively in rats and dogs. However, these models differ greatly in reproductive physiology compared with women. The purpose of this study was to evaluate histomorphometric changes in iliac crest bone biopsies taken from cynomolgus mon...

journal_title：Bone

authors： Lees CJ,Jerome CP

更新日期：1998-05-01 00:00:00

abstract：:Bone resorption is a multistep process including osteoclast attachment, cytoskeletal reorganization, formation of four distinct plasma membrane domains, and matrix demineralization and degradation followed by cell detachment. The present study describes the intracellular mechanisms by which overexpression of cathepsin...

journal_title：Bone

authors： Morko J,Kiviranta R,Mulari MT,Ivaska KK,Väänänen HK,Vuorio E,Laitala-Leinonen T

更新日期：2009-04-01 00:00:00

abstract：:In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...

journal_title：Bone

authors： Casanova M,Herelle J,Thomas M,Softley R,Schindeler A,Little D,Schneider P,Müller R

更新日期：2016-11-01 00:00:00

abstract：:Paralysis of the masticatory muscles using botulinum toxin (BTX) is a common treatment for cosmetic reduction of the masseters as well as for conditions involving muscle spasm and pain. The effects of this treatment on mastication have not been evaluated, and claims that the treatment unloads the jaw joint and mandibl...

journal_title：Bone

authors： Rafferty KL,Liu ZJ,Ye W,Navarrete AL,Nguyen TT,Salamati A,Herring SW

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). ...

journal_title：Bone

authors： Zhang Q,Greenbaum J,Zhang WD,Sun CQ,Deng HW

更新日期：2018-12-01 00:00:00

abstract：:Second generation antipsychotics (SGAs) have been linked to metabolic and bone disorders in clinical studies, but the mechanisms of these side effects remain unclear. Additionally, no studies have examined whether SGAs cause bone loss in mice. Using in vivo and in vitro modeling we examined the effects of risperidone,...

journal_title：Bone

authors： Motyl KJ,Dick-de-Paula I,Maloney AE,Lotinun S,Bornstein S,de Paula FJ,Baron R,Houseknecht KL,Rosen CJ

更新日期：2012-02-01 00:00:00

abstract：:Osteocyte canalicular density (OCD) was evaluated at different levels of the wall of human secondary osteons, in subjects of different ages, to find out whether any correlation exists between the extension of the canalicular network and the exponential decrement of the appositional growth rate (AGR), which has been sh...

journal_title：Bone

authors： Marotti G,Ferretti M,Remaggi F,Palumbo C

更新日期：1995-01-01 00:00:00

abstract：:Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...

journal_title：Bone

authors： Bellows CG,Ciaccia A,Heersche JN

更新日期：1998-08-01 00:00:00

abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...

journal_title：Bone

authors： Adami S,Rossini M

更新日期：1992-01-01 00:00:00

abstract：:Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...

journal_title：Bone

authors： Xie M,Chagin AS

更新日期：2021-01-01 00:00:00

abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...

journal_title：Bone

authors： Yamaza T,Tsuji Y,Goto T,Kido MA,Nishijima K,Moroi R,Akamine A,Tanaka T

更新日期：2001-07-01 00:00:00

abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...

journal_title：Bone

authors： Jonasson G,Sundh V,Ahlqwist M,Hakeberg M,Björkelund C,Lissner L

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. METHODS:The study was part of the Dubbo Oste...

journal_title：Bone

authors： Mai HT,Tran TS,Ho-Le TP,Pham TT,Center JR,Eisman JA,Nguyen TV

更新日期：2018-11-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00

abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

journal_title：Bone

authors： Minkoff JR,Grant BF,Marcus R

更新日期：1985-01-01 00:00:00

abstract：:To determine osteocalcin (OC) and adipokines in type 1 diabetes (T1D) and healthy controls, and to explore possible associations between glucose and bone metabolism, body composition and adipokines. Serum levels of total OC, undercarboxylated (UC-OC), leptin, adiponectin, and other parameters of glucose and bone metab...

journal_title：Bone

authors： Neumann T,Lodes S,Kästner B,Franke S,Kiehntopf M,Lehmann T,Müller UA,Wolf G,Sämann A

更新日期：2016-01-01 00:00:00

abstract：:In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...

journal_title：Bone

authors： Bollerslev J,Marks SC Jr,Pockwinse S,Kassem M,Brixen K,Steiniche T,Mosekilde L

更新日期：1993-11-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...

journal_title：Bone

authors： Dela Cruz A,Mattocks M,Sugamori KS,Grynpas MD,Mitchell J

更新日期：2014-02-01 00:00:00

abstract：:The distribution of hyaluronan was investigated in the proximal tibiotarsal bones of normal (vitamin D-treated) chicks, and chicks with rachitic lesions induced by vitamin D deficiency. Localization studies using a biotinylated hyaluronan-binding probe revealed that in vitamin D-treated chicks, a high level of hyaluro...

journal_title：Bone

authors： Genever PG,Dickson IR

更新日期：1996-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...

journal_title：Bone

authors： Weivoda MM,Lee SK,Monroe DG

更新日期：2021-02-01 00:00:00

abstract：:Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...

journal_title：Bone

authors： Jasper LE,Deramond H,Mathis JM,Belkoff SM

更新日期：1999-08-01 00:00:00

abstract：:The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...

journal_title：Bone

authors： Gundersen HJ,Boyce RW,Nyengaard JR,Odgaard A

更新日期：1993-05-01 00:00:00

abstract：:Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...

journal_title：Bone

authors： Tatara MR,Sliwa E,Krupski W,Brodzki A,Pasternak K

更新日期：2006-07-01 00:00:00

abstract：:Postmenopausal osteoporosis is characterized by a reduction in the numbers of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion suggesting a role of vascular component in the pathogenesis of osteoporosis. Previous studies have shown that bone formation and angiogenesis are positively co...

journal_title：Bone

authors： Zhao Q,Shen X,Zhang W,Zhu G,Qi J,Deng L

更新日期：2012-03-01 00:00:00

abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...

journal_title：Bone

authors： Elli FM,Barbieri AM,Bordogna P,Ferrari P,Bufo R,Ferrante E,Giardino E,Beck-Peccoz P,Spada A,Mantovani G

更新日期：2013-10-01 00:00:00