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Atypical insufficiency fractures confused with Looser zones of osteomalacia.

Abstract：

:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as assessed by single-energy photon absorptiometry at the midshaft of the radius. Two postmenopausal women had vertebral compression fractures. Biochemical indices and bone histomorphometric analysis excluded osteomalacia, and in vivo double tetracycline labeling in five patients revealed both high and low bone turnover states. We propose more stringent radiographic criteria for the designation of the term "Looser zone" that retains the customary association between the radiologic event and osteomalacia. This paper also outlines a diagnostic strategy for future cases of atypical insufficiency fractures and proposes reasons for their resemblance to true Looser zones.

journal_name

Bone

journal_title

Bone

authors

McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

doi

10.1016/8756-3282(87)90073-1

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

71-8

issue

2

eissn

8756-3282

issn

1873-2763

pii

8756-3282(87)90073-1

journal_volume

8

pub_type

杂志文章

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