Expression of bone microsomal casein kinase II, bone sialoprotein, and osteopontin during the repair of calvarial defects.

abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

journal_title：Bone

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

更新日期：2002-04-01 00:00:00

abstract：:Bone sialoprotein (BSP) is a multifunctional extracellular matrix protein found in mineralized tissues, including bone, cartilage, tooth root cementum (both acellular and cellular types), and dentin. In order to define the role BSP plays in the process of biomineralization of these tissues, we analyzed cementogenesis,...

journal_title：Bone

authors： Foster BL,Ao M,Willoughby C,Soenjaya Y,Holm E,Lukashova L,Tran AB,Wimer HF,Zerfas PM,Nociti FH Jr,Kantovitz KR,Quan BD,Sone ED,Goldberg HA,Somerman MJ

更新日期：2015-09-01 00:00:00

abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...

journal_title：Bone

authors： Gasser JA

更新日期：1995-10-01 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：:In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...

journal_title：Bone

authors： Grynpas MD,Rey C

更新日期：1992-01-01 00:00:00

abstract：:Tight interactions among different cell types contributing to bone formation are of key importance in the maintenance of bone homeostasis. Based on the high similarity in responses to (anti)osteogenic signals between zebrafish scales and mammalian bone, we developed and validated a model to screen large numbers of com...

journal_title：Bone

authors： de Vrieze E,Zethof J,Schulte-Merker S,Flik G,Metz JR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...

journal_title：Bone

authors： Kang SY,Deshpande SS,Donneys A,Rodriguez JJ,Nelson NS,Felice PA,Chepeha DB,Buchman SR

更新日期：2013-09-01 00:00:00

abstract：:The correlation between bone mineral density and vertebral strength is not based on mechanical principles and thus the method cannot reflect the effects of subtle geometric features and densitometric inhomogeneities that may substantially affect vertebral strength. Finite element models derived from quantitative compu...

journal_title：Bone

authors： Crawford RP,Cann CE,Keaveny TM

更新日期：2003-10-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...

journal_title：Bone

authors： Xiao H,Xie X,Wen Y,Tan Y,Shangguan Y,Li B,Magdalou J,Wang H,Chen L

更新日期：2020-04-01 00:00:00

abstract：:Estrogen and calcium deficiencies increase both bone resorption and formation, whereas immobilization mainly decreases bone formation. How these functionally different risk factors for bone loss interact in cancellous bone undergoing modeling or remodeling activity is not well understood. Mature (6-month-old) female r...

journal_title：Bone

authors： Shen V,Liang XG,Birchman R,Wu DD,Healy D,Lindsay R,Dempster DW

更新日期：1997-07-01 00:00:00

abstract：:The aim of this study was to estimate the burden of childhood rickets-like bone deformity in a rural region of West Africa where rickets has been reported in association with a low calcium intake. A population-based survey of children aged 0.5-17.9 years living in the province of West Kiang, The Gambia was conducted i...

journal_title：Bone

authors： Jones HL,Jammeh L,Owens S,Fulford AJ,Moore SE,Pettifor JM,Prentice A

更新日期：2015-08-01 00:00:00

abstract：:Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...

journal_title：Bone

authors： Lu X,Ito Y,Atsawasuwan P,Dangaria S,Yan X,Wu T,Evans CA,Luan X

更新日期：2013-05-01 00:00:00

abstract：:Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...

journal_title：Bone

authors： Nagahama K,Aoki K,Nonaka K,Saito H,Takahashi M,Varghese BJ,Shimokawa H,Azuma M,Ohya K,Ohyama K

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To assess the ability of the Spanish version of the WHO fracture risk assessment tool (FRAX®) to predict the observed incident fractures in the ECOSAP Study cohort. METHODS:5201 women, aged 65 or older, were enrolled in a three-year, prospective study by a non-randomized sampling of consecutive cases in 58 pri...

journal_title：Bone

authors： González-Macías J,Marin F,Vila J,Díez-Pérez A

更新日期：2012-01-01 00:00:00

abstract：:Obesity in humans is associated with increased bone mass. Leptin, a hormone produced by fat cells, functions as a sentinel of energy balance, and may mediate the putative positive effects of body mass on bone. We performed studies in male C57Bl/6 wild type (WT) and leptin-deficient ob/ob mice to determine whether body...

journal_title：Bone

authors： Iwaniec UT,Dube MG,Boghossian S,Song H,Helferich WG,Turner RT,Kalra SP

更新日期：2009-03-01 00:00:00

abstract：:Sclerostin, product of the SOST gene, is an important determinant of bone formation and resorption. Adolescents with anorexia nervosa (AN) have low bone density and decreased levels of bone turnover markers. However, sclerostin has not been examined in AN as a potential mediator of impaired bone metabolism. Our study ...

journal_title：Bone

authors： Faje AT,Fazeli PK,Katzman DK,Miller KK,Breggia A,Rosen CJ,Mendes N,Klibanski A,Misra M

更新日期：2012-09-01 00:00:00

abstract：:Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...

journal_title：Bone

authors： Wallace JM,Rajachar RM,Allen MR,Bloomfield SA,Robey PG,Young MF,Kohn DH

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:The present study was designed to evaluate the relationships between ultrasonic backscatter, density, and microarchitecture of cancellous bone. The slopes of the frequency-dependent attenuation coefficient (nBUA), ultrasound bone velocity (UBV), the frequency-averaged backscatter coefficient (BUB) were measured in 25 ...

journal_title：Bone

authors： Chaffaî S,Peyrin F,Nuzzo S,Porcher R,Berger G,Laugier P

更新日期：2002-01-01 00:00:00

abstract：:Avian tibial dyschondroplasia is a disorder of endochondral ossification which results in the accumulation of noncalcified, avascular cartilage. We have investigated the changes in cell proliferation and enzyme activities within specific cell types in the growth plate of chickens with differing severity of the disease...

journal_title：Bone

authors： Farquharson C,Whitehead C,Rennie S,Thorp B,Loveridge N

更新日期：1992-01-01 00:00:00

abstract：:Despite the fact that the medications used to treat abnormal bone conditions often induce osteonecrosis of the jaw (ONJ), previous attempts to establish an animal model for ONJ have shown insufficient consideration for this important prerequisite for the development of the disease. The purpose of this study was to est...

journal_title：Bone

authors： Kim JW,Tatad JCI,Landayan MEA,Kim SJ,Kim MR

更新日期：2015-12-01 00:00:00

abstract：:Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...

journal_title：Bone

authors： Carriero A,Bruse JL,Oldknow KJ,Millán JL,Farquharson C,Shefelbine SJ

更新日期：2014-12-01 00:00:00

abstract：:Many osteoporotic fracture patients are candidates for concurrent treatment with bisphosphonates and bioceramic bone graft substitutes. Osteopromotive silica-based bioactive glasses are known to induce accelerated local bone turnover and adjunct antiresorptive agents, such as zoledronic acid, may affect the process. T...

journal_title：Bone

authors： Välimäki VV,Moritz N,Yrjans JJ,Vuorio E,Aro HT

更新日期：2006-03-01 00:00:00

abstract：:SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...

journal_title：Bone

authors： Lhaneche L,Hald JD,Domingues A,Hannouche D,Delepine M,Zelenika D,Boland A,Ostertag A,Cohen-Solal M,Langdahl BL,Harsløf T,de Vernejoul MC,Geoffroy V,Jehan F

更新日期：2016-11-01 00:00:00

abstract：:Although it is generally acknowledged that matrix vesicles and alkaline phosphatase are required for cartilage calcification, their precise role in initiation or propagation of mineralization remains controversial. We have investigated this problem in a neoplastic model of chondrogenesis, the Swarm rat chondrosarcoma....

journal_title：Bone

authors： Miller GJ,DeMarzo AM

更新日期：1988-01-01 00:00:00

abstract：:Impaired osteoblast and osteocyte maturation contribute to mineralization defects and excess FGF23 expression in CKD bone. Vitamin D sterols decrease osteoid accumulation and increase FGF23 expression; these agents also increase osteoblast maturation in vitro but a link between changes in bone cell maturation, bone mi...

journal_title：Bone

authors： Pereira RC,Salusky IB,Bowen RE,Freymiller EG,Wesseling-Perry K

更新日期：2019-10-01 00:00:00

abstract：:Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...

journal_title：Bone

authors： Iwasaki Y,Kazama JJ,Yamato H,Fukagawa M

更新日期：2011-06-01 00:00:00

abstract：:Changes in skeletal remodeling (biochemical bone markers) and regional bone mineral density (spine, hip, and forearm bone mineral density [BMD]) were observed for 3 years in 20 patients (15 women and 5 men; age 54 +/- 11 years, range 29-69 years) after successful surgery for primary hyperparathyroidism (PHPT). Fifteen...

journal_title：Bone

authors： Christiansen P,Steiniche T,Brixen K,Hessov I,Melsen F,Heickendorff L,Mosekilde L

更新日期：1999-11-01 00:00:00

abstract：:With age, alterations occurring in bone quality, quantity, and microarchitecture affect the resistance of trabecular bone to local failure. The clinical implications of these changes are evident by the observed exponential increase in fracture incidence with age. Although age-related development of skeletal fragility ...

journal_title：Bone

authors： Nagaraja S,Lin AS,Guldberg RE

更新日期：2007-04-01 00:00:00

abstract：:Impact microindentation (IMI) is a Reference Point Indentation technique measuring tissue-level properties of cortical bone in humans in vivo. The nature, however, of the properties that can affect bone strength is incompletely understood. In the present study we examined bone material properties in transiliac bone bi...

journal_title：Bone

authors： Rokidi S,Bravenboer N,Gamsjaeger S,Misof B,Blouin S,Chavassieux P,Klaushofer K,Paschalis E,Papapoulos S,Appelman-Dijkstra N

更新日期：2020-02-01 00:00:00