Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats.

abstract：:Vitamin K may be important in bone metabolism. Notably, high-dose menaquinone-4 (menatetrenone, MK4) has been reported to reduce ovariectomy (ovx)-induced bone loss in rats and to decrease osteoporotic fracture in postmenopausal women. However, it is unclear whether these beneficial effects reflect a physiologic effec...

journal_title：Bone

authors： Binkley N,Krueger D,Engelke J,Crenshaw T,Suttie J

更新日期：2002-06-01 00:00:00

abstract：:Although ovariectomized cynomolgus monkeys are used extensively for studies examining perimenopausal changes in the skeleton, very little is known about the changes that occur naturally during growth and aging in these animals. To evaluate the changes in bone during growth and aging in female cynomolgus monkeys, 29 mo...

journal_title：Bone

authors： Lees CJ,Ramsay H

更新日期：1999-01-01 00:00:00

abstract：:Increased levels of reactive oxygen species (ROS) are a crucial pathogenic factor of osteoporosis. Gastrodin, isolated from the traditional Chinese herbal agent Gastrodia elata, is a potent antioxidant. We hypothesized that gastrodin demonstrates protective effects against osteoporosis by partially reducing reactive o...

journal_title：Bone

authors： Huang Q,Shi J,Gao B,Zhang HY,Fan J,Li XJ,Fan JZ,Han YH,Zhang JK,Yang L,Luo ZJ,Liu J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...

journal_title：Bone

authors： Blom-Høgestøl IK,Hewitt S,Chahal-Kummen M,Brunborg C,Gulseth HL,Kristinsson JA,Eriksen EF,Mala T

更新日期：2019-10-01 00:00:00

abstract：:Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin function significantly ...

journal_title：Bone

authors： Hamrick MW,Shi X,Zhang W,Pennington C,Thakore H,Haque M,Kang B,Isales CM,Fulzele S,Wenger KH

更新日期：2007-06-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:Solute transport in the lacunar-canalicular system (LCS) is essential for bone metabolism and mechanotransduction. Using the technique of fluorescence recovery after photobleaching (FRAP) we have been quantifying solute transport in the LCS of murine long bone as a function of loading parameters and molecular size. Ho...

journal_title：Bone

authors： Zhou X,Novotny JE,Wang L

更新日期：2009-10-01 00:00:00

abstract：:Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now al...

journal_title：Bone

authors： Simon D,Kleyer A,Englbrecht M,Stemmler F,Simon C,Berlin A,Kocijan R,Haschka J,Hirschmann S,Atreya R,Neurath MF,Sticherling M,Rech J,Hueber AJ,Engelke K,Schett G

更新日期：2018-11-01 00:00:00

abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

journal_title：Bone

authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

更新日期：2007-04-01 00:00:00

abstract：:Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...

journal_title：Bone

authors： Saito M,Shiraishi A,Ito M,Sakai S,Hayakawa N,Mihara M,Marumo K

更新日期：2010-04-01 00:00:00

abstract：:A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involve...

journal_title：Bone

authors： Yazdanpanah N,Zillikens MC,Rivadeneira F,de Jong R,Lindemans J,Uitterlinden AG,Pols HA,van Meurs JB

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts is involved in the progression of osteoarthritis (OA). Human osteoblasts isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/ß-catenin pathway, and a reduced mine...

journal_title：Bone

authors： Abed E,Bouvard B,Martineau X,Jouzeau JY,Reboul P,Lajeunesse D

更新日期：2015-06-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：:We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Fetal calf serum (FCS) stimulated the formation of choline in a dose-dependent manner in the range between 0.6% and 10%. The effect of a combination of FCS and 12-O-te...

journal_title：Bone

authors： Tokuda H,Suzuki A,Watanabe-Tomita Y,Shinoda J,Imamura Y,Oiso Y,Igata A,Kozawa O

更新日期：1996-10-01 00:00:00

abstract：:Interleukin (IL)-17 is crucial to osteoclast differentiation and activation. Osteocytes support osteoclast formation and are thought to orchestrate bone remodeling in response to fluid flow. The contribution of IL-17 to osteocyte-related bone resorption remains unclear. Here, we used the osteocyte-like MLO-Y4 cell lin...

journal_title：Bone

authors： Liao C,Cheng T,Wang S,Zhang C,Jin L,Yang Y

更新日期：2017-08-01 00:00:00

abstract：:Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...

journal_title：Bone

authors： Davis JW,Grove JS,Wasnich RD,Ross PD

更新日期：1999-03-01 00:00:00

abstract：:High doses of caffeine will induce calcium loss and influence the normal development of bone, whereas the proper exercise has positive effects on bone metabolism. This study investigated the possible effects of exercise to antagonize the caffeine-induced impairment of bone development in young male Wistar rats. A tota...

journal_title：Bone

authors： Huang TH,Yang RS,Hsieh SS,Liu SH

更新日期：2002-01-01 00:00:00

abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...

journal_title：Bone

authors： Cheung WY,Simmons CA,You L

更新日期：2012-01-01 00:00:00

abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...

journal_title：Bone

authors： Weilner S,Skalicky S,Salzer B,Keider V,Wagner M,Hildner F,Gabriel C,Dovjak P,Pietschmann P,Grillari-Voglauer R,Grillari J,Hackl M

更新日期：2015-10-01 00:00:00

abstract：:Three distinct osteoblastic cell lines (KS418, KS460, and KS483) were subcloned from the mouse osteoblastic KS-4 cells, which possessed the abilities not only to differentiate into mature osteoblasts, but also to support osteoclast differentiation in coculture with spleen cells. The order of the magnitude of the basal...

journal_title：Bone

authors： Yamashita T,Ishii H,Shimoda K,Sampath TK,Katagiri T,Wada M,Osawa T,Suda T

更新日期：1996-11-01 00:00:00

abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...

journal_title：Bone

authors： Ardawi MS,Maimani AA,Bahksh TA,Rouzi AA,Qari MH,Raddadi RM

更新日期：2010-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can self-renew and differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. It's reported that bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic BMPs to initiate the commitment of MSCs to osteoblast lineage. Cyclooxygenase-2 (COX-2) is critical...

journal_title：Bone

authors： Wang JH,Liu YZ,Yin LJ,Chen L,Huang J,Liu Y,Zhang RX,Zhou LY,Yang QJ,Luo JY,Zuo GW,Deng ZL,He BC

更新日期：2013-11-01 00:00:00

abstract：:The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...

journal_title：Bone

authors： Kanis JA

更新日期：1995-08-01 00:00:00

abstract：:Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...

journal_title：Bone

authors： Adam C,Glück L,Ebert R,Goebeler M,Jakob F,Schmidt M

更新日期：2018-06-01 00:00:00

abstract：:Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...

journal_title：Bone

authors： Journé F,Dumon JC,Kheddoumi N,Fox J,Laïos I,Leclercq G,Body JJ

更新日期：2004-08-01 00:00:00

abstract：:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...

journal_title：Bone

authors： Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

更新日期：2002-07-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...

journal_title：Bone

authors： Kosugi K,Tajima T,Menuki K,Okuma KF,Tokuda K,Fukuda H,Okada Y,Tsukamoto M,Yamanaka Y,Zenke Y,Sakai A

更新日期：2020-07-01 00:00:00

abstract：:If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injectio...

journal_title：Bone

authors： Manske SL,Boyd SK,Zernicke RF

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta th...

journal_title：Bone

authors： Ekbote V,Padidela R,Khadilkar V,Ramanan V,Maheshwari A,Mughal Z,Kariki EP,Crabtree N,Khadilkar A

更新日期：2021-02-01 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00