The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice.

abstract：:Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium-phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2...

journal_title：Bone

authors： Wang B,Yang Y,Liu L,Blair HC,Friedman PA

更新日期：2013-01-01 00:00:00

abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...

journal_title：Bone

authors： Schneiders W,Reinstorf A,Pompe W,Grass R,Biewener A,Holch M,Zwipp H,Rammelt S

更新日期：2007-04-01 00:00:00

abstract：:The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...

journal_title：Bone

authors： Yan L,Prentice A,Zhou B,Zhang H,Wang X,Stirling DM,Laidlaw A,Han Y,Laskey A

更新日期：2002-02-01 00:00:00

abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...

journal_title：Bone

authors： Ma L,Duan CC,Yang ZQ,Ding JL,Liu S,Yue ZP,Guo B

更新日期：2019-06-01 00:00:00

abstract：:Old age-associated osteoporosis is related to diminished bone blood flow and impaired nitric oxide (NO)-mediated vasodilation of the bone vasculature. Endurance exercise training restores the age-associated reduction of vasodilation in numerous vascular beds, as well as improving bone properties. The purpose of this s...

journal_title：Bone

authors： Dominguez JM 2nd,Prisby RD,Muller-Delp JM,Allen MR,Delp MD

更新日期：2010-03-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

journal_title：Bone

authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

更新日期：2012-03-01 00:00:00

abstract：:Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...

journal_title：Bone

authors： Lu X,Ito Y,Atsawasuwan P,Dangaria S,Yan X,Wu T,Evans CA,Luan X

更新日期：2013-05-01 00:00:00

abstract：:Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent...

journal_title：Bone

authors： Wenger KH,Freeman JD,Fulzele S,Immel DM,Powell BD,Molitor P,Chao YJ,Gao HS,Elsalanty M,Hamrick MW,Isales CM,Yu JC

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...

journal_title：Bone

authors： Strube P,Mehta M,Baerenwaldt A,Trippens J,Wilson CJ,Ode A,Perka C,Duda GN,Kasper G

更新日期：2009-12-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...

journal_title：Bone

authors： Weilner S,Skalicky S,Salzer B,Keider V,Wagner M,Hildner F,Gabriel C,Dovjak P,Pietschmann P,Grillari-Voglauer R,Grillari J,Hackl M

更新日期：2015-10-01 00:00:00

abstract：:Avian tibial dyschondroplasia is a disorder of endochondral ossification which results in the accumulation of noncalcified, avascular cartilage. We have investigated the changes in cell proliferation and enzyme activities within specific cell types in the growth plate of chickens with differing severity of the disease...

journal_title：Bone

authors： Farquharson C,Whitehead C,Rennie S,Thorp B,Loveridge N

更新日期：1992-01-01 00:00:00

abstract：:Both mechanical loading and nitric oxide (NO) have positive influences on bone mass. NO production is induced by mechanical strain via upregulation of eNOS mRNA and protein, the predominant NOS in adult bone. At the same time, strain causes decreased expression of RANKL, a factor critical for osteoclastogenesis. In th...

journal_title：Bone

authors： Rahnert J,Fan X,Case N,Murphy TC,Grassi F,Sen B,Rubin J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Preterm infants are at risk for impaired bone mineralization and growth in length later in life due to inadequate nutritional intake in the early postnatal period. OBJECTIVE:To investigate whether increased nutritional supplementation of calcium, phosphate and protein in Very Low Birth Weight (VLBW) infants...

journal_title：Bone

authors： Christmann V,van der Putten ME,Rodwell L,Steiner K,Gotthardt M,van Goudoever JB,van Heijst AFJ

更新日期：2018-03-01 00:00:00

abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

journal_title：Bone

authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

更新日期：2011-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can self-renew and differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. It's reported that bone morphogenetic protein 9 (BMP9) is one of the most potent osteogenic BMPs to initiate the commitment of MSCs to osteoblast lineage. Cyclooxygenase-2 (COX-2) is critical...

journal_title：Bone

authors： Wang JH,Liu YZ,Yin LJ,Chen L,Huang J,Liu Y,Zhang RX,Zhou LY,Yang QJ,Luo JY,Zuo GW,Deng ZL,He BC

更新日期：2013-11-01 00:00:00

abstract：:We have previously shown that the therapeutic range of ultrasound heals osteoradionecrotic bone and induces bone formation in vitro. It is well established that nitric oxide (NO) and prostaglandins are crucial early mediators in mechanically induced bone formation. The therapeutic range of ultrasound may act in the sa...

journal_title：Bone

authors： Reher P,Harris M,Whiteman M,Hai HK,Meghji S

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. METHODS AND RESULTS:We systematically retrieved 13 obse...

journal_title：Bone

authors： Yang S,Nguyen ND,Eisman JA,Nguyen TV

更新日期：2012-11-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00

abstract：:Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...

journal_title：Bone

authors： Li Z,Zhou Z,Yellowley CE,Donahue HJ

更新日期：1999-12-01 00:00:00

abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

journal_title：Bone

authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

更新日期：2012-09-01 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

journal_title：Bone

authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

更新日期：2021-02-01 00:00:00

abstract：:The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were us...

journal_title：Bone

authors： Panseri S,Russo A,Sartori M,Giavaresi G,Sandri M,Fini M,Maltarello MC,Shelyakova T,Ortolani A,Visani A,Dediu V,Tampieri A,Marcacci M

更新日期：2013-10-01 00:00:00

abstract：:This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...

journal_title：Bone

authors： Harris SS,Wood MJ,Dawson-Hughes B

更新日期：1995-04-01 00:00:00

abstract：:Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the tibia, resists loss of neutral lipid with acute, 48-hour fasting in rats. The mechanisms underlying this phenomenon and its seemingly distinct...

journal_title：Bone

authors： Scheller EL,Khandaker S,Learman BS,Cawthorn WP,Anderson LM,Pham HA,Robles H,Wang Z,Li Z,Parlee SD,Simon BR,Mori H,Bree AJ,Craft CS,MacDougald OA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect wa...

journal_title：Bone

authors： Cointry GR,Mondelo N,Zanchetta JR,Montuori E,Ferretti JL

更新日期：1995-10-01 00:00:00

abstract：:The prevalence of osteoarthritis (OA) is greater in women then men. Weight, a factor strongly associated with osteoarthritis, is significantly increased over the menopausal transition. Despite the high prevalence of osteoarthritis, a disabling disease with limited treatment options, there is a paucity of studies in wo...

journal_title：Bone

authors： Szoeke CEI,Cicuttini FM,Guthrie JR,Clark MS,Dennerstein L

更新日期：2006-11-01 00:00:00

abstract：:This review begins with an introduction to the malignant bone tumor, osteosarcoma [OS] and then moves to a discussion of the commonly used vectors for gene transfer. We first briefly highlight non-viral vectors including polymeric and liposomal delivery systems but concentrate predominantly on the 5 leading viral vect...

journal_title：Bone

authors： Witlox MA,Lamfers ML,Wuisman PI,Curiel DT,Siegal GP

更新日期：2007-04-01 00:00:00