Abstract:
:Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect was paralleled by changes in material quality indicators as DEXA-BMD, tomographic (volumetric) BMD, elastic modulus, and maximum elastic stress of cortical bone. No changes were induced by any of the treatments on cross-sectional area or moment of inertia. Diaphyseal stiffness, not reduced by OX, was enhanced to overnormal values by olpadronate at any dose. None of the treatments affected the normal mechanostatic interrelationships between cross-sectional architecture and bone material quality indicators. The positive effects described point out important differences in bisphosphonate action on bone biomechanics according to the experimental conditions assayed.
journal_name
Bonejournal_title
Boneauthors
Cointry GR,Mondelo N,Zanchetta JR,Montuori E,Ferretti JLdoi
10.1016/8756-3282(95)00314-4subject
Has Abstractpub_date
1995-10-01 00:00:00pages
373S-378Sissue
4 Suppleissn
8756-3282issn
1873-2763pii
8756-3282(95)00314-4journal_volume
17pub_type
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