Effect of modification of hydroxyapatite/collagen composites with sodium citrate, phosphoserine, phosphoserine/RGD-peptide and calcium carbonate on bone remodelling.

abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...

journal_title：Bone

authors： Okihana H,Shimomura Y

更新日期：1992-01-01 00:00:00

abstract：:A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of postmenopausal osteoporosis. We have utilized the ovariohysterectomized (Ovh) dog to examine cellular and biochemical responses to estrogen depletion and PTH stim...

journal_title：Bone

authors： Shen V,Dempster DW,Birchman R,Mellish RW,Church E,Kohn D,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin in endochondral ossification at the growth plate. The growth plates of wild-type and ob/ob mice were analyzed. Effects of leptin on c...

journal_title：Bone

authors： Kishida Y,Hirao M,Tamai N,Nampei A,Fujimoto T,Nakase T,Shimizu N,Yoshikawa H,Myoui A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

journal_title：Bone

authors： Whitney DG,Devlin MJ,Alford AI,Caird MS

更新日期：2021-01-01 00:00:00

abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...

journal_title：Bone

authors： Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

更新日期：2019-06-01 00:00:00

abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

journal_title：Bone

authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

更新日期：1997-10-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) isolated from extracted third molar ...

journal_title：Bone

authors： Tóth F,Gáll JM,Tőzsér J,Hegedűs C

更新日期：2020-03-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:Although basic fibroblast growth factor (bFGF) is a potent stimulator of bone formation when administered intravenously, less is known regarding the effects of this peptide on bone following subcutaneous (s.c.) administration. In addition, it is unknown whether coadministration of estrogen enhances the bone response t...

journal_title：Bone

authors： Iwaniec UT,Magee KA,Mitova-Caneva NG,Wronski TJ

更新日期：2003-09-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...

journal_title：Bone

authors： Palvanen M,Kannus P,Niemi S,Parkkari J

更新日期：2010-05-01 00:00:00

abstract：:Using immunohistology with two specific antisera raised against N-terminal parathyroid hormone-related protein (PTHrP) and in situ hybridization (riboprobe to common coding exon), evidence is provided for the expression of PTHrP by mouse, rabbit, and human osteoclasts derived from several in vitro and in vivo sources....

journal_title：Bone

authors： Kartsogiannis V,Udagawa N,Ng KW,Martin TJ,Moseley JM,Zhou H

更新日期：1998-03-01 00:00:00

abstract：:Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate chondrocytes could protect the calcification of en...

journal_title：Bone

authors： Xu HG,Yu YF,Zheng Q,Zhang W,Wang CD,Zhao XY,Tong WX,Wang H,Liu P,Zhang XL

更新日期：2014-09-01 00:00:00

abstract：:The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro e...

journal_title：Bone

authors： Yianni V,Sharpe PT

更新日期：2020-05-01 00:00:00

abstract：:FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...

journal_title：Bone

authors： Varanasi SS,Datta HK

更新日期：2005-02-01 00:00:00

abstract：:Recent studies have indicated a critical role for vascular endothelial growth factor (VEGF) during the process of endochondral ossification, in particular in coupling cartilage resorption with bone formation. Therefore, we studied the chemoattractive and proliferative properties of human VEGF-A on primary human osteob...

journal_title：Bone

authors： Mayr-Wohlfart U,Waltenberger J,Hausser H,Kessler S,Günther KP,Dehio C,Puhl W,Brenner RE

更新日期：2002-03-01 00:00:00

abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...

journal_title：Bone

authors： Takahashi K,Tsuboyama T,Matsushita M,Kasai R,Okumura H,Yamamuro T,Okamoto Y,Kitagawa K,Takeda T

更新日期：1994-03-01 00:00:00

abstract：:In an effort to elucidate the interplay between mechanical load and proteolytic gene expression in arthritic tissue degradation, we investigated cellular morphology and mRNA levels of matrix metalloproteinase-13 (MMP-13) genes under mechanical stress in human MH7A synovial cells. The cells were isolated from the knee ...

journal_title：Bone

authors： Sun HB,Yokota H

更新日期：2001-04-01 00:00:00

abstract：:Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...

journal_title：Bone

authors： Shankar G,Stern PH

更新日期：1993-11-01 00:00:00

abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

journal_title：Bone

authors： Minkoff JR,Grant BF,Marcus R

更新日期：1985-01-01 00:00:00

abstract：:Teeth with intact crowns rarely split or fracture, despite decades of cyclic loading and occasional unexpected overload. This is largely attributed to the presence of dentine, since cracking and fracture of enamel have been frequently reported. Dentine is similar to bone, comprising mineralised collagen fibres as a ma...

journal_title：Bone

authors： Fleck C,Burke M,Ganzosch G,Müller C,Currey JD,Zaslansky P

更新日期：2020-03-01 00:00:00

abstract：:To facilitate an understanding of the dependence of ultrasound velocity and attenuation upon the material and structural properties of cancellous bone, several theoretical concepts for ultrasound propagation have been adapted or developed, including the Biot theory and several scattering theories. Biot theory consider...

journal_title：Bone

authors： Haire TJ,Langton CM

更新日期：1999-04-01 00:00:00

abstract：:There are conflicting reports on the influence of lean and fat mass on bone accrual during childhood. No infant's studies have been reported that describe the influence of changes in body composition with changes in bone accrual during the first year of life. The objective of this research was to test the hypothesis t...

journal_title：Bone

authors： Sudhagoni RG,Wey HE,Djira GD,Specker BL

更新日期：2012-03-01 00:00:00

abstract：:The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...

journal_title：Bone

authors： Okumura H,Yamamuro T,Kasai R,Hayashi T,Tada K,Nishii Y

更新日期：1987-01-01 00:00:00

abstract：:We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...

journal_title：Bone

authors： Fang MA,Frost PJ,Iida-Klein A,Hahn TJ

更新日期：1991-01-01 00:00:00

abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

journal_title：Bone

authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

更新日期：2003-09-01 00:00:00

abstract：:To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...

journal_title：Bone

authors： Bjarnason NH,Bjarnason K,Hassager C,Christiansen C

更新日期：1997-02-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...

journal_title：Bone

authors： Imel EA,Liu Z,McQueen AK,Acton D,Acton A,Padgett LR,Peacock M,Econs MJ

更新日期：2016-05-01 00:00:00

abstract：:One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...

journal_title：Bone

authors： Peng ZQ,Väänänen HK,Zhang HX,Tuukkanen J

更新日期：1997-03-01 00:00:00

abstract：:SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...

journal_title：Bone

authors： Lhaneche L,Hald JD,Domingues A,Hannouche D,Delepine M,Zelenika D,Boland A,Ostertag A,Cohen-Solal M,Langdahl BL,Harsløf T,de Vernejoul MC,Geoffroy V,Jehan F

更新日期：2016-11-01 00:00:00