Abstract:
:The aim of this study was to estimate the burden of childhood rickets-like bone deformity in a rural region of West Africa where rickets has been reported in association with a low calcium intake. A population-based survey of children aged 0.5-17.9 years living in the province of West Kiang, The Gambia was conducted in 2007. 6221 children, 92% of those recorded in a recent census, were screened for physical signs of rickets by a trained survey team with clinical referral of suspected cases. Several objective measures were tested as potential screening tools. The prevalence of bone deformity in children <18.0 years was 3.3%. The prevalence was greater in males (M = 4.3%, F = 2.3%, p < 0.001) and in children <5.0 years (5.7%, M = 8.3%, F = 2.9%). Knock-knee was more common (58%) than bow-leg (31%) or windswept deformity (9%). Of the 196 examined clinically, 36 were confirmed to have a deformity outside normal variation (47% knock-knee, 53% bow-leg), resulting in more conservative prevalence estimates of bone deformity: 0.6% for children <18.0 years (M = 0.9%, F = 0.2%), 1.5% for children < 5.0 years (M = 2.3%, F = 0.6%). Three of these children (9% of those with clinically-confirmed deformity, 0.05% of those screened) had active rickets on X-ray at the time of medical examination. This emphasises the difficulties in comparing prevalence estimates of rickets-like bone deformities from population surveys and clinic-based studies. Interpopliteal distance showed promise as an objective screening measure for bow-leg deformity. In conclusion, this population survey in a rural region of West Africa with a low calcium diet has demonstrated a significant burden of rickets-like bone deformity, whether based on physical signs under survey conditions or after clinical examination, especially in boys < 5.0 years.
journal_name
Bonejournal_title
Boneauthors
Jones HL,Jammeh L,Owens S,Fulford AJ,Moore SE,Pettifor JM,Prentice Adoi
10.1016/j.bone.2015.04.011subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1-5eissn
8756-3282issn
1873-2763pii
S8756-3282(15)00124-6journal_volume
77pub_type
杂志文章相关文献
BONE文献大全abstract::We investigated the effect of 2-beta-(3-hydroxypropoxy)-1alpha,25-dihydroxyvitamin D3 (ED-71) on the modeling of bone in distraction osteogenesis. The tibiae of 30 rabbits were lengthened by 10 mm in 10 days. Following osteotomy, ED-71 (0.05 microg/kg) was administered subcutaneously twice a week to the ED-71 group un...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00179-3
更新日期:1999-03-01 00:00:00
abstract::Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00176-3
更新日期:1999-09-01 00:00:00
abstract::The role of drinking water fluoride content for prevention of osteoporosis remains controversial. Therefore, we analyzed the influence of drinking water fluoridation on the incidence of osteoporotic hip fractures and bone mineral density (BMD) in two different communities in eastern Germany: in Chemnitz, drinking wate...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00273-1
更新日期:1998-03-01 00:00:00
abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.013
更新日期:2005-07-01 00:00:00
abstract::Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(88)90115-9
更新日期:1988-01-01 00:00:00
abstract::Fracture healing is a regenerative process in which bone is restored without scar tissue formation. The healing cascade initiates with a cycle of inflammation, cell migration, proliferation and differentiation. Immune cells invade the fracture site immediately upon bone damage and contribute to the initial phase of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.03.052
更新日期:2014-07-01 00:00:00
abstract::The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.010
更新日期:2015-04-01 00:00:00
abstract::Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain. The glycosylated B chain binds specifically to galactose moieties of sugar molecules. In this study we showed that the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.02.018
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.021
更新日期:2016-11-01 00:00:00
abstract::Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.036
更新日期:2019-06-01 00:00:00
abstract::The traditional view of osteoporotic fractures is that they result from a reduction in bone mass combined with alterations in the micro-architecture. Apart from the effects of bone remodeling, the material properties of the remaining bone are thought to be unaffected. To test this, we compared the degree of matrix min...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.05.025
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.12.005
更新日期:2008-04-01 00:00:00
abstract::Osteoporosis is a major cause of disability in the United States. Numerous factors contribute to the decline in bone mineral density (BMD) that characterizes this disease, and the importance of heredity is now widely appreciated. We evaluated the joint contributions of genes and environmental factors on variation in B...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00246-1
更新日期:2003-11-01 00:00:00
abstract::The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were us...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.07.015
更新日期:2013-10-01 00:00:00
abstract::The potency of magnetic resonance imaging (MRI) to measure the exact extent of osteonecrosis of the femoral head (ONFH) remains uncertain. The objective of this study was to determine if the volume of necrosis assessed with MRI accurately reflects the volume of architectural mineral alterations in osteonecrosis of the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115099
更新日期:2020-01-01 00:00:00
abstract::Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that administration of t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.010
更新日期:2009-05-01 00:00:00
abstract::Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00778-0
更新日期:2002-07-01 00:00:00
abstract::The use of combined antiretroviral agents during pregnancy is important to prevent mother-to-child transmission of human immunodeficiency virus (HIV). Antiretroviral treatment (ARV) is associated with reduced bone mass and altered bone metabolism in HIV-infected patients. There are no data regarding the effect of ARV ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.030
更新日期:2012-01-01 00:00:00
abstract::Hypophosphatasia (HPP) is a multi-systemic inborn disease with an extraordinary spectrum of severity, ranging from the absence of mineralization to high lethality and it involves different organs including bone, muscle, kidney, lung, gastrointestinal tract and the nervous system. The disease is characterized by low le...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.10.022
更新日期:2017-01-01 00:00:00
abstract::Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal muscle mass and strength in mid-life and then experience a progressive decline of up to 50% by the ninth decade. The loss of muscle mass a...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2019.05.021
更新日期:2019-10-01 00:00:00
abstract::Compounds, like beta-aminopropionitrile (bAPN) and homocysteine (hcys), are known to inhibit a stable matrix formation. Osteoblast-synthesized collagen matrix regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase, an enzyme involved in the collagen cross-linking process. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.10.038
更新日期:2010-03-01 00:00:00
abstract::Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.06.037
更新日期:2011-11-01 00:00:00
abstract::Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90192-y
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years. MATERIALS AND METHODS:A validated Markov microsimulation model with a Belgian payer's perspective estimated the cost per quality-adjusted life-year (QALY) of a 3-year strontium r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.08.052
更新日期:2010-02-01 00:00:00
abstract::Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlled by the cytokine R...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.113
更新日期:2012-11-01 00:00:00
abstract::A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.04.008
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Low-intensity pulsed ultrasound (LIPUS) has distinct effects on biologic mineralization at intensities of <100 mW/cm2. Intensity-dependent differences in the pattern of accelerated mineralization may be due to different alterations in regulation of collagenous matrix formation. However, little is known about the influ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.04.024
更新日期:2004-09-01 00:00:00
abstract::How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(98)00156-2
更新日期:1999-02-01 00:00:00
abstract::The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults. However, evidence ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2017.08.008
更新日期:2018-10-01 00:00:00