Abstract:
:The skeleton is characterized by anatomic heterogeneity of metabolic turnover. Site-dependent differences in hormonal effects seem likely. Hyporesponsiveness of osteoclasts to parathyroid hormone (PTH) and probably calcitriol was recently demonstrated in the fifth lumbar vertebra of a rat model with moderate renal failure. We compared histomorphometric findings of the tibial head to these data. Histomorphometric measurements were carried out in sections of the right tibial head of pair-fed male Sprague-Dawley rats. Subtotally nephrectomized (SNx), parathyroidectomized (PTx), rats, which received either solvent or rat PTH(1-34) (100 ng/kg per hour) + calcitriol (5 pmol/kg per hour) via osmotic minipumps were compared with sham-operated controls. Results were compared with data from the fifth lumbar vertebra reported recently. Osteoclast numerical density and osteoclast surface density were lower in the tibial head and the lumbar vertebra of solvent-treated SNxPTx rats than in sham-operated controls (p < 0.05), and could not be returned to normal by the substitution of PTH + calcitriol (p < 0.05). On the other hand, there were differences between interventional effects on the tibial head and on the lumbar vertebra concerning parameters describing osteoblasts and trabecular bone volume. In the tibial head, osteoblast surface density was nearly unchanged in both interventions. Nevertheless, bone volume increased after SNxPTx without substitution of PTH + calcitriol (p < 0.05), and no further changes occurred after hormonal replacement. In contrast, osteoblast surface density in the lumbar vertebra was decreased slightly compared with values in sham-operated rats; a clear but nonsignificant increase occurred after the administration of calcitropic hormones. This was accompanied by unchanged trabecular bone volume after SNxPTx. Hormonal replacement, however, caused an increase in trabecular bone volume (p < 0.05), which represents an anabolic effect, which contrasts with findings from the tibial head. The different interventional effects on the lumbar spine and on peripheral bone, regarding the parameters reflecting the condition of osteoblasts, may be intrinsic to the uremic syndrome itself as well as to dissimilar growth manner, function, and mechanical requirements. The findings substantiate the site dependence of bone surface cell metabolism in renal failure and should be the subject of further study. Corresponding results with regard to bone resorption argue for a bone-site-independent, diminished response of osteoclasts to calcitropic hormones.
journal_name
Bonejournal_title
Boneauthors
Freesmeyer MG,Abendroth K,Faldum A,Krauss C,Stein Gdoi
10.1016/s8756-3282(01)00502-6subject
Has Abstractpub_date
2001-09-01 00:00:00pages
258-64issue
3eissn
8756-3282issn
1873-2763pii
S8756-3282(01)00502-6journal_volume
29pub_type
杂志文章相关文献
BONE文献大全abstract::Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration (LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone. Our previous study found that LMHFV significantly enhanced fracture healing in adult rats. This study was designed to explore whether LMHFV was able t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.028
更新日期:2010-05-01 00:00:00
abstract::Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain. The glycosylated B chain binds specifically to galactose moieties of sugar molecules. In this study we showed that the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.02.018
更新日期:2011-06-01 00:00:00
abstract::Adipose-derived adult stem cells (ASCs), like their bone-marrow derived counterparts, possess the ability to differentiate down osteogenic, chondrogenic, adipogenic, and myogenic pathways. For bone differentiation of mouse ASCs (mASCs), retinoic-acid mediated upregulation of BMPR-IB has been found to be necessary. Int...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.01.026
更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2006.02.003
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:Autosomal recessive osteopetrosis (ARO) is a rare congenital disorder of defective bone resorption. The inability of osteoclasts to resorb bone compromises the development of bone marrow cavity, and ultimately, leads to defective hematopoiesis and death within the first decade. The only curative treatment cur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115144
更新日期:2020-01-01 00:00:00
abstract::Paget's disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is the second most frequent bone disorder. PDB is a focal disorder affecting the skeleton segmentally but the cause of which is unknown. It has been hypothesised that somatic mutations could be responsible for the mosaicism described in...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.04.003
更新日期:2018-07-01 00:00:00
abstract::Previous reports have shown that bone mass and architecture will partially recover by remobilization (RM) in immobilization (IM)-induced osteopenia. The aim of this study was to test whether PTH can accelerate the recovery during RM from the IM-induced osteopenia. Six-month-old Sprague-Dawley female rats were divided ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00295-o
更新日期:1995-10-01 00:00:00
abstract::Micro- and nanoscale surface modifications have been the focus of multiple studies in the pursuit of accelerating bone apposition or osseointegration at the implant surface. Here, we evaluated histological and nanomechanical properties, and gene expression, for a microblasted surface presenting nanometer-scale texture...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.05.004
更新日期:2014-08-01 00:00:00
abstract::Bone mineral density is under strong genetic control and polymorphisms of the vitamin D receptor (VDR) have been suggested to account for some of the genetic variation in bone mass. However, the relationship between VDR polymorphisms and bone density is controversial and has not been confirmed by all workers. Since th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00483-1
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.129
更新日期:2012-12-01 00:00:00
abstract::New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.05.021
更新日期:2008-10-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.05.024
更新日期:2010-08-01 00:00:00
abstract::There is a persuasive rationale from the use of hormone replacement therapy (HRT) at the time of the menopause, but there are a number of factors which limit its widespread application for osteoporosis. These relate partly to the long-term efficacy of HRT when given for a finite duration at the time of the menopause, ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(96)90163-5
更新日期:1996-11-01 00:00:00
abstract::A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(96)00077-4
更新日期:1996-06-01 00:00:00
abstract::Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.167
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.015
更新日期:2018-12-01 00:00:00
abstract::Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.07.012
更新日期:2012-01-01 00:00:00
abstract::The aim of the study was to assess the biomechanical effects of short-term PTH treatment and withdrawal on bone mass and strength in an aged, osteopenic, ovariectomized (ovx) rat model. Additionally, the effect of sequential therapy with PTH and the bisphosphonate, risedronate, the effect of longterm PTH monotherapy, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00024-0
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115508
更新日期:2020-09-01 00:00:00
abstract::In this study we investigate bone metabolism in patients with rheumatoid arthritis (RA), with or without joint destruction, using serum biochemical markers of bone turnover. Three hundred eighteen patients (disease duration >2 years; mean 9 years) were divided into those with joint destruction, that is, with Larsen wr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00193-8
更新日期:1999-04-01 00:00:00
abstract::Analysis of tissue from a 34-years-old male patient from Austrian origin with a history of multiple fractures associated with painful episodes over the carpal, tarsal and at the end of the long bones respectively is presented. Radiographic images and axial 3DCT scans showed widespread defects in trabecular bone archit...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.10.008
更新日期:2019-06-01 00:00:00
abstract::Pre-clinical in vivo models of multiple myeloma are essential tools for investigating the pathophysiology of multiple myeloma and for testing new therapeutic agents and strategies prior to their potential use in clinical trials. Over the last five decades, several different types of murine models of multiple myeloma h...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.04.004
更新日期:2015-08-01 00:00:00
abstract::Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00222-9
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bon...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.11.041
更新日期:2013-03-01 00:00:00
abstract::Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115610
更新日期:2021-02-01 00:00:00
abstract::Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00227-6
更新日期:1999-12-01 00:00:00
abstract::Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00681-6
更新日期:2002-04-01 00:00:00
abstract::This in vivo study investigated the influence of two calcium phosphate particle sizes (40-80 microm and 200-500 microm) on the cellular degradation activity associated with the bone substitution process of two injectable bone substitutes (IBS). The tested biomaterials were obtained by associating a biphasic calcium ph...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00137-4
更新日期:1999-08-01 00:00:00
abstract::Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.011
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115772
更新日期:2021-01-01 00:00:00